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A review of the prospects for vaccination in African trypanosomiasis. Part I

This review of the prospects for developing an immunization procedure against trypanosomiasis explores a number of promising avenues of research. Part I covers variable antigen types (VATs); metacyclic antigens; in vivo and in vitro attenuation; and molecular and genetic engineering. Part II, to be...

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Main Authors: Murray, M., Barry, J.D., Morrison, W. Ivan, Williams, R.O., Hirumi, H., Rovis, L.A.
Format: Journal Article
Language:Inglés
Published: 1979
Subjects:
trypanosomiasis
vaccines
antigens
genetic engineering
Online Access:https://hdl.handle.net/10568/28622
Summary:This review of the prospects for developing an immunization procedure against trypanosomiasis explores a number of promising avenues of research. Part I covers variable antigen types (VATs); metacyclic antigens; in vivo and in vitro attenuation; and molecular and genetic engineering. Part II, to be included in the next issue of this journal, will cover immunogenicity of subcellular fractions; immunological intervention against the tsetse fly; induction of increased resistance by immunostimulants; trypanotolerance; and infection and treatment. This will be followed by a brief statement of the conclusions reached.

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