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Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolerance...

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Main Authors: Park, S.D.E., Adomefa, K., Dao, B., Hanotte, Olivier H., Kemp, Stephen J., Sow, R.S., Teale, A.J., Bradley, D.G.
Format: Journal Article
Language:Inglés
Published: 1999
Subjects:
population genetics
genetic maps
selection
disease resistance
trypanosomiasis
cattle
genetic markers
heterozygotes
genetic distance
Online Access:https://hdl.handle.net/10568/28361
Summary:We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolerance. Population genetic analysis is used with mapped microsatellites to try to infer selection for trypanotolerance in West African cattle populations.

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