IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4
Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, has been implicated in the pathogenesis of various neurological disorders. IDO expression is induced by IFN-gamma and leads to neurotoxicity by generating quinolinic acid. Additionally, it inhibits the immune response through both...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
2007
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1864 |
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