East Coast fever mRNA vaccines – sweetening the promise
The mRNA vaccine platform should help research on East Coast fever subunit vaccines, but it remains unexplored. A theoretical strength of this platform, namely its capacity to prime cytotoxic T lymphocyte responses, is appealing as these, rather than antibodies, are the major mediators of immunity i...
| Autor principal: | |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2025
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| Acceso en línea: | https://hdl.handle.net/10568/175623 |
| _version_ | 1855538657970094080 |
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| author | Nene, Vishvanath |
| author_browse | Nene, Vishvanath |
| author_facet | Nene, Vishvanath |
| author_sort | Nene, Vishvanath |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The mRNA vaccine platform should help research on East Coast fever subunit vaccines, but it remains unexplored. A theoretical strength of this platform, namely its capacity to prime cytotoxic T lymphocyte responses, is appealing as these, rather than antibodies, are the major mediators of immunity induced by a live parasite-based vaccine. Here, I highlight knowledge on functionally relevant bovine adaptive cellular and antibody immune responses to <i>Theileria parva</i> and antigens targeted by them that could help to assess this vaccine platform, and in the design of a broad-spectrum subunit vaccine. The view that N-glycosylated parasite antigens may exist is unlikely as the pathogen does not encode genomic capacity to catalyze this post-translational modification. |
| format | Journal Article |
| id | CGSpace175623 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1756232025-10-26T12:56:46Z East Coast fever mRNA vaccines – sweetening the promise Nene, Vishvanath east coast fever vaccines The mRNA vaccine platform should help research on East Coast fever subunit vaccines, but it remains unexplored. A theoretical strength of this platform, namely its capacity to prime cytotoxic T lymphocyte responses, is appealing as these, rather than antibodies, are the major mediators of immunity induced by a live parasite-based vaccine. Here, I highlight knowledge on functionally relevant bovine adaptive cellular and antibody immune responses to <i>Theileria parva</i> and antigens targeted by them that could help to assess this vaccine platform, and in the design of a broad-spectrum subunit vaccine. The view that N-glycosylated parasite antigens may exist is unlikely as the pathogen does not encode genomic capacity to catalyze this post-translational modification. 2025-08 2025-07-14T03:57:10Z 2025-07-14T03:57:10Z Journal Article https://hdl.handle.net/10568/175623 en Limited Access Elsevier Nene, V. 2025. East Coast fever mRNA vaccines – sweetening the promise. Trends in Parasitology 41(8): 620–627. |
| spellingShingle | east coast fever vaccines Nene, Vishvanath East Coast fever mRNA vaccines – sweetening the promise |
| title | East Coast fever mRNA vaccines – sweetening the promise |
| title_full | East Coast fever mRNA vaccines – sweetening the promise |
| title_fullStr | East Coast fever mRNA vaccines – sweetening the promise |
| title_full_unstemmed | East Coast fever mRNA vaccines – sweetening the promise |
| title_short | East Coast fever mRNA vaccines – sweetening the promise |
| title_sort | east coast fever mrna vaccines sweetening the promise |
| topic | east coast fever vaccines |
| url | https://hdl.handle.net/10568/175623 |
| work_keys_str_mv | AT nenevishvanath eastcoastfevermrnavaccinessweeteningthepromise |