East Coast fever mRNA vaccines – sweetening the promise
The mRNA vaccine platform should help research on East Coast fever subunit vaccines, but it remains unexplored. A theoretical strength of this platform, namely its capacity to prime cytotoxic T lymphocyte responses, is appealing as these, rather than antibodies, are the major mediators of immunity i...
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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Elsevier
2025
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| Acceso en línea: | https://hdl.handle.net/10568/175623 |
| Sumario: | The mRNA vaccine platform should help research on East Coast fever subunit vaccines, but it remains unexplored. A theoretical strength of this platform, namely its capacity to prime cytotoxic T lymphocyte responses, is appealing as these, rather than antibodies, are the major mediators of immunity induced by a live parasite-based vaccine. Here, I highlight knowledge on functionally relevant bovine adaptive cellular and antibody immune responses to <i>Theileria parva</i> and antigens targeted by them that could help to assess this vaccine platform, and in the design of a broad-spectrum subunit vaccine. The view that N-glycosylated parasite antigens may exist is unlikely as the pathogen does not encode genomic capacity to catalyze this post-translational modification. |
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