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Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL

Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elabor...

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Main Authors: Dixit, Shalabh, Kumar Biswal, Akshaya, Min, Aye, Henry, Amelia, Oane, Rowena H., Raorane, Manish L., Longkumer, Toshisangba, Pabuayon, Isaiah M., Mutte, Sumanth K., Vardarajan, Adithi R., Miro, Berta, Govindan, Ganesan, Albano-Enriquez, Blesilda, Pueffeld, Mandy, Sreenivasulu, Nese, Slamet-Loedin, Inez, Sundarvelpandian, Kalaipandian, Tsai, Yuan-Ching, Raghuvanshi, Saurabh, Hsing, Yue-Ie C., Kumar, Arvind, Kohli, Ajay
Format: Journal Article
Language:Inglés
Published: Springer 2015
Subjects:
breeding methods
drought tolerance
food security
genotypes
plant breeding
quantitative trait loci
transcription factors
yields
Online Access:https://hdl.handle.net/10568/165377
Summary:Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ (OsNAM12.1) and its co-localized target genes of separate GO categories for qDTY12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY12.1has fast-tracked rice improvement towards food security.

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