Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL
Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elabor...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/165377 |
| _version_ | 1855525265405378560 |
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| author | Dixit, Shalabh Kumar Biswal, Akshaya Min, Aye Henry, Amelia Oane, Rowena H. Raorane, Manish L. Longkumer, Toshisangba Pabuayon, Isaiah M. Mutte, Sumanth K. Vardarajan, Adithi R. Miro, Berta Govindan, Ganesan Albano-Enriquez, Blesilda Pueffeld, Mandy Sreenivasulu, Nese Slamet-Loedin, Inez Sundarvelpandian, Kalaipandian Tsai, Yuan-Ching Raghuvanshi, Saurabh Hsing, Yue-Ie C. Kumar, Arvind Kohli, Ajay |
| author_browse | Albano-Enriquez, Blesilda Dixit, Shalabh Govindan, Ganesan Henry, Amelia Hsing, Yue-Ie C. Kohli, Ajay Kumar Biswal, Akshaya Kumar, Arvind Longkumer, Toshisangba Min, Aye Miro, Berta Mutte, Sumanth K. Oane, Rowena H. Pabuayon, Isaiah M. Pueffeld, Mandy Raghuvanshi, Saurabh Raorane, Manish L. Slamet-Loedin, Inez Sreenivasulu, Nese Sundarvelpandian, Kalaipandian Tsai, Yuan-Ching Vardarajan, Adithi R. |
| author_facet | Dixit, Shalabh Kumar Biswal, Akshaya Min, Aye Henry, Amelia Oane, Rowena H. Raorane, Manish L. Longkumer, Toshisangba Pabuayon, Isaiah M. Mutte, Sumanth K. Vardarajan, Adithi R. Miro, Berta Govindan, Ganesan Albano-Enriquez, Blesilda Pueffeld, Mandy Sreenivasulu, Nese Slamet-Loedin, Inez Sundarvelpandian, Kalaipandian Tsai, Yuan-Ching Raghuvanshi, Saurabh Hsing, Yue-Ie C. Kumar, Arvind Kohli, Ajay |
| author_sort | Dixit, Shalabh |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ (OsNAM12.1) and its co-localized target genes of separate GO categories for qDTY12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY12.1has fast-tracked rice improvement towards food security. |
| format | Journal Article |
| id | CGSpace165377 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1653772024-12-19T14:12:36Z Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL Dixit, Shalabh Kumar Biswal, Akshaya Min, Aye Henry, Amelia Oane, Rowena H. Raorane, Manish L. Longkumer, Toshisangba Pabuayon, Isaiah M. Mutte, Sumanth K. Vardarajan, Adithi R. Miro, Berta Govindan, Ganesan Albano-Enriquez, Blesilda Pueffeld, Mandy Sreenivasulu, Nese Slamet-Loedin, Inez Sundarvelpandian, Kalaipandian Tsai, Yuan-Ching Raghuvanshi, Saurabh Hsing, Yue-Ie C. Kumar, Arvind Kohli, Ajay breeding methods drought tolerance food security genotypes plant breeding quantitative trait loci transcription factors yields Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ (OsNAM12.1) and its co-localized target genes of separate GO categories for qDTY12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY12.1has fast-tracked rice improvement towards food security. 2015-10-28 2024-12-19T12:55:01Z 2024-12-19T12:55:01Z Journal Article https://hdl.handle.net/10568/165377 en Open Access Springer Dixit, Shalabh; Kumar Biswal, Akshaya; Min, Aye; Henry, Amelia; Oane, Rowena H.; Raorane, Manish L.; Longkumer, Toshisangba; Pabuayon, Isaiah M.; Mutte, Sumanth K.; Vardarajan, Adithi R.; Miro, Berta; Govindan, Ganesan; Albano-Enriquez, Blesilda; Pueffeld, Mandy; Sreenivasulu, Nese; Slamet-Loedin, Inez; Sundarvelpandian, Kalaipandian; Tsai, Yuan-Ching; Raghuvanshi, Saurabh; Hsing, Yue-Ie C.; Kumar, Arvind and Kohli, Ajay. 2015. Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL. Sci Rep, Volume 5, no. 1 |
| spellingShingle | breeding methods drought tolerance food security genotypes plant breeding quantitative trait loci transcription factors yields Dixit, Shalabh Kumar Biswal, Akshaya Min, Aye Henry, Amelia Oane, Rowena H. Raorane, Manish L. Longkumer, Toshisangba Pabuayon, Isaiah M. Mutte, Sumanth K. Vardarajan, Adithi R. Miro, Berta Govindan, Ganesan Albano-Enriquez, Blesilda Pueffeld, Mandy Sreenivasulu, Nese Slamet-Loedin, Inez Sundarvelpandian, Kalaipandian Tsai, Yuan-Ching Raghuvanshi, Saurabh Hsing, Yue-Ie C. Kumar, Arvind Kohli, Ajay Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title | Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title_full | Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title_fullStr | Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title_full_unstemmed | Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title_short | Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL |
| title_sort | action of multiple intra qtl genes concerted around a co localized transcription factor underpins a large effect qtl |
| topic | breeding methods drought tolerance food security genotypes plant breeding quantitative trait loci transcription factors yields |
| url | https://hdl.handle.net/10568/165377 |
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