Segmental duplications drive the evolution of accessory regions in a major crop pathogen
Many pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host rang...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2024
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/149052 |
| _version_ | 1855533229747994624 |
|---|---|
| author | van Westerhoven, A.C. Aguilera-Galvez, C. Nakasato-Tagami, G. Shi-Kunne, X. de la Parte, E.M. Chavarro-Carrero, E. Meijer, H.J.G. Feurtey, A. Maryani, N. Ordonez, N. Schneiders, H. Nijbroek, K. Wittenberg, A.H.J. Hofstede, R. Garcia-Bastidas, F. Sorensen, A. Swennen, R. Drenth, A. Stukenbrock, E.H. Kema, G.H.J. Seidl, M.F. |
| author_browse | Aguilera-Galvez, C. Chavarro-Carrero, E. Drenth, A. Feurtey, A. Garcia-Bastidas, F. Hofstede, R. Kema, G.H.J. Maryani, N. Meijer, H.J.G. Nakasato-Tagami, G. Nijbroek, K. Ordonez, N. Schneiders, H. Seidl, M.F. Shi-Kunne, X. Sorensen, A. Stukenbrock, E.H. Swennen, R. Wittenberg, A.H.J. de la Parte, E.M. van Westerhoven, A.C. |
| author_facet | van Westerhoven, A.C. Aguilera-Galvez, C. Nakasato-Tagami, G. Shi-Kunne, X. de la Parte, E.M. Chavarro-Carrero, E. Meijer, H.J.G. Feurtey, A. Maryani, N. Ordonez, N. Schneiders, H. Nijbroek, K. Wittenberg, A.H.J. Hofstede, R. Garcia-Bastidas, F. Sorensen, A. Swennen, R. Drenth, A. Stukenbrock, E.H. Kema, G.H.J. Seidl, M.F. |
| author_sort | van Westerhoven, A.C. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Many pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host range, and horizontal transfer of ARs can modify the pathogenicity of the receiving strain. However, how these ARs evolve in strains that infect the same host remains largely unknown.
We defined the pan-genome of 69 diverse F. oxysporum strains that cause Fusarium wilt of banana, a significant constraint to global banana production, and analyzed the diversity and evolution of the ARs.
Accessory regions in F. oxysporum strains infecting the same banana cultivar are highly diverse, and we could not identify any shared genomic regions and in planta-induced effectors. We demonstrate that segmental duplications drive the evolution of ARs. Furthermore, we show that recent segmental duplications specifically in accessory chromosomes cause the expansion of ARs in F. oxysporum.
Taken together, we conclude that extensive recent duplications drive the evolution of ARs in F. oxysporum, which contribute to the evolution of virulence. |
| format | Journal Article |
| id | CGSpace149052 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1490522025-12-08T09:54:28Z Segmental duplications drive the evolution of accessory regions in a major crop pathogen van Westerhoven, A.C. Aguilera-Galvez, C. Nakasato-Tagami, G. Shi-Kunne, X. de la Parte, E.M. Chavarro-Carrero, E. Meijer, H.J.G. Feurtey, A. Maryani, N. Ordonez, N. Schneiders, H. Nijbroek, K. Wittenberg, A.H.J. Hofstede, R. Garcia-Bastidas, F. Sorensen, A. Swennen, R. Drenth, A. Stukenbrock, E.H. Kema, G.H.J. Seidl, M.F. fusarium oxysporum genomes pathogens evolution Many pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host range, and horizontal transfer of ARs can modify the pathogenicity of the receiving strain. However, how these ARs evolve in strains that infect the same host remains largely unknown. We defined the pan-genome of 69 diverse F. oxysporum strains that cause Fusarium wilt of banana, a significant constraint to global banana production, and analyzed the diversity and evolution of the ARs. Accessory regions in F. oxysporum strains infecting the same banana cultivar are highly diverse, and we could not identify any shared genomic regions and in planta-induced effectors. We demonstrate that segmental duplications drive the evolution of ARs. Furthermore, we show that recent segmental duplications specifically in accessory chromosomes cause the expansion of ARs in F. oxysporum. Taken together, we conclude that extensive recent duplications drive the evolution of ARs in F. oxysporum, which contribute to the evolution of virulence. 2024-04 2024-07-12T09:07:13Z 2024-07-12T09:07:13Z Journal Article https://hdl.handle.net/10568/149052 en Open Access application/pdf Wiley van Westerhoven, A. C., Aguilera‐Galvez, C., Nakasato‐Tagami, G., Shi‐Kunne, X., Martinez de la Parte, E., Chavarro‐Carrero, E., ... & Seidl, M. F. (2024). Segmental duplications drive the evolution of accessory regions in a major crop pathogen. New Phytologist, 242(2), 610-625. |
| spellingShingle | fusarium oxysporum genomes pathogens evolution van Westerhoven, A.C. Aguilera-Galvez, C. Nakasato-Tagami, G. Shi-Kunne, X. de la Parte, E.M. Chavarro-Carrero, E. Meijer, H.J.G. Feurtey, A. Maryani, N. Ordonez, N. Schneiders, H. Nijbroek, K. Wittenberg, A.H.J. Hofstede, R. Garcia-Bastidas, F. Sorensen, A. Swennen, R. Drenth, A. Stukenbrock, E.H. Kema, G.H.J. Seidl, M.F. Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title | Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title_full | Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title_fullStr | Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title_full_unstemmed | Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title_short | Segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| title_sort | segmental duplications drive the evolution of accessory regions in a major crop pathogen |
| topic | fusarium oxysporum genomes pathogens evolution |
| url | https://hdl.handle.net/10568/149052 |
| work_keys_str_mv | AT vanwesterhovenac segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT aguileragalvezc segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT nakasatotagamig segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT shikunnex segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT delaparteem segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT chavarrocarreroe segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT meijerhjg segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT feurteya segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT maryanin segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT ordonezn segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT schneidersh segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT nijbroekk segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT wittenbergahj segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT hofsteder segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT garciabastidasf segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT sorensena segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT swennenr segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT drentha segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT stukenbrockeh segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT kemaghj segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen AT seidlmf segmentalduplicationsdrivetheevolutionofaccessoryregionsinamajorcroppathogen |