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A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of...

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Main Authors: Graham, S.P., Honda, Y., Pelle, Roger, Mwangi, David Miano, Glew, E.J., Villiers, Etienne P. de, Shah, Tushaar, Bishop, Richard P., Bruggen, P. van der, Nene, Vishvanath M., Taracha, E.L.N.
Format: Journal Article
Language:Inglés
Published: Springer 2007
Subjects:
animal diseases
disease control
Online Access:https://hdl.handle.net/10568/1394
Summary:Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL.

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