A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2007
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1394 |
| _version_ | 1855542577789403136 |
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| author | Graham, S.P. Honda, Y. Pelle, Roger Mwangi, David Miano Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. |
| author_browse | Bishop, Richard P. Bruggen, P. van der Glew, E.J. Graham, S.P. Honda, Y. Mwangi, David Miano Nene, Vishvanath M. Pelle, Roger Shah, Tushaar Taracha, E.L.N. Villiers, Etienne P. de |
| author_facet | Graham, S.P. Honda, Y. Pelle, Roger Mwangi, David Miano Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. |
| author_sort | Graham, S.P. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL. |
| format | Journal Article |
| id | CGSpace1394 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2007 |
| publishDateRange | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace13942024-05-01T08:20:03Z A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology Graham, S.P. Honda, Y. Pelle, Roger Mwangi, David Miano Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. animal diseases disease control Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL. 2007 2010-05-06T09:07:49Z 2010-05-06T09:07:49Z Journal Article https://hdl.handle.net/10568/1394 en Open Access Springer Graham, S.P.; Honda, Y.; Pelle, R. et al. 2007. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immunome Research 3:2. |
| spellingShingle | animal diseases disease control Graham, S.P. Honda, Y. Pelle, Roger Mwangi, David Miano Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath M. Taracha, E.L.N. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title | A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title_full | A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title_fullStr | A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title_full_unstemmed | A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title_short | A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology |
| title_sort | novel strategy for the identification of antigens that are recognised by bovine mhc class i restricted cytotoxic t cells in a protozoan infection using reverse vaccinology |
| topic | animal diseases disease control |
| url | https://hdl.handle.net/10568/1394 |
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