Escape from CD8+ T Cell Response by Natural Variants of an Immunodominant Epitope from Theileria parva Is Predominantly Due to Loss of TCR Recognition
Polymorphism of immunodominant CD8+ T cell epitopes can facilitate escape from immune recognition of pathogens, leading to strain-specific immunity. In this study, we examined the TCR β-chain (TRB) diversity of the CD8+ T cell responses of cattle against two immunodominant epitopes from Theileria pa...
| Autores principales: | , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
American Association of Immunologists
2011
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/129357 |
Ejemplares similares: Escape from CD8+ T Cell Response by Natural Variants of an Immunodominant Epitope from Theileria parva Is Predominantly Due to Loss of TCR Recognition
- The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality
- CD8 T‐cell responses against the immunodominant Theileria parva peptide Tp2 49–59 are composed of two distinct populations specific for overlapping 11‐mer and 10‐mer epitopes
- Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva
- Extensive Polymorphism and Evidence of Immune Selection in a Highly Dominant Antigen Recognized by Bovine CD8 T Cells Specific for Theileria annulata
- Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
- Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM