Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion
Today evidence exist that environmental chemicals deteriorate male sperm quality and that testicular cancer is increasing. Bisphenol A (BPA) is a chemical with estrogenic effects used in the manufacture of polycarbonate plastic and are found in, for instance, plastic boxes, feeding bottles and food...
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| Formato: | First cycle, G2E |
| Lenguaje: | sueco sueco |
| Publicado: |
2015
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| Acceso en línea: | https://stud.epsilon.slu.se/8028/ |
| _version_ | 1855571283144605696 |
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| author | Lindell, Malin |
| author_browse | Lindell, Malin |
| author_facet | Lindell, Malin |
| author_sort | Lindell, Malin |
| collection | Epsilon Archive for Student Projects |
| description | Today evidence exist that environmental chemicals deteriorate male sperm quality and that testicular cancer is increasing. Bisphenol A (BPA) is a chemical with estrogenic effects used in the manufacture of polycarbonate plastic and are found in, for instance, plastic boxes, feeding bottles and food containers. Much of the research on how men's reproductive ability is influenced are performed on rats. This review article complies how male rat reproduction is affected by BPA as a model for humans. Studies have investigated how sperm are affected, hormonal changes during reproduction and how reactive oxygen species (ROS) affects sperm. The results show that sperm quality and sperm motility is deteriorating if rats are exposed to BPA. The negative feedback regulation of testosterone decrease, leading to an increase of luteinizing hormone (LH), which in turn leads to a decrease of testicular function. A decrease of LH is also found that indicate a decrease of pituitary secretion of LH. Increased ROS production after exposure to BPA is making sperm unable to protect themselves and they end up in oxidative stress. Thus, there is evidence that male rats have an impaired fertility caused by exposure to BPA. Through further research the effects of BPA can be clarified in more detail, give us a better understanding of how BPA can cause deterioration of sperm quality and if there is a link to the increase in testicular cancer that is seen in humans. |
| format | First cycle, G2E |
| id | RepoSLU8028 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish swe |
| publishDate | 2015 |
| publishDateSort | 2015 |
| record_format | eprints |
| spelling | RepoSLU80282015-06-12T12:37:02Z https://stud.epsilon.slu.se/8028/ Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion Lindell, Malin Animal physiology - Reproduction Today evidence exist that environmental chemicals deteriorate male sperm quality and that testicular cancer is increasing. Bisphenol A (BPA) is a chemical with estrogenic effects used in the manufacture of polycarbonate plastic and are found in, for instance, plastic boxes, feeding bottles and food containers. Much of the research on how men's reproductive ability is influenced are performed on rats. This review article complies how male rat reproduction is affected by BPA as a model for humans. Studies have investigated how sperm are affected, hormonal changes during reproduction and how reactive oxygen species (ROS) affects sperm. The results show that sperm quality and sperm motility is deteriorating if rats are exposed to BPA. The negative feedback regulation of testosterone decrease, leading to an increase of luteinizing hormone (LH), which in turn leads to a decrease of testicular function. A decrease of LH is also found that indicate a decrease of pituitary secretion of LH. Increased ROS production after exposure to BPA is making sperm unable to protect themselves and they end up in oxidative stress. Thus, there is evidence that male rats have an impaired fertility caused by exposure to BPA. Through further research the effects of BPA can be clarified in more detail, give us a better understanding of how BPA can cause deterioration of sperm quality and if there is a link to the increase in testicular cancer that is seen in humans. Idag finns det bevis på att miljökemikalier försämrar männens spermiekvalité och att testikelcancer ökar. Bisfenol A (BPA) är en kemikalie med östrogena effekter som används vid tillverkning av polykarbonatplast, vilket återfinns i bland annat plastlådor, nappflaskor och livsmedelsbehållare. Mycket av forskningen som utförs gällande hur männens reproduktiva förmåga påverkas utförs på råttor. Denna litteraturstudie sammanställer hur hanråttors reproduktion påverkas av BPA som en modell för människa. Studier har undersökt hur spermier påverkas, vilka hormoner som förändras under reproduktionen och hur reaktiva syreföreningar (ROS) påverkar spermier. Resultaten visar att spermiekvalitén och spermiers motilitet försämras om råttorna exponeras för BPA. Den negativa feedback regleringen av testosteron minskar vilket leder till att luteiniserande hormon (LH) ökar som i sin tur leder till att testikelfunktionen bromsas. En minskning av LH har även upptäckts, vilket indikerar en minskad hypofys sekretion av LH. Ökad ROS produktion vid exponering för BPA gör att spermier inte kan skydda sig och hamnar i oxidativ stress. Därmed finns det bevis på att hanråttor får en försämrad fertilitet vid exponering för BPA. Genom fortsatta studier kan effekten av BPA kartläggas mer i detalj, förståelsen ökar för hur BPA kan orsaka försämring av spermiekvalitén och om det finns en koppling till ökningen av testikelcancer hos människan. 2015-06-12 First cycle, G2E NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/8028/7/lindell_m_150611.pdf Lindell, Malin, 2015. Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion. First cycle, G2E. Uppsala: (VH) > Dept. of Anatomy, Physiology and Biochemistry (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-712.html> urn:nbn:se:slu:epsilon-s-4455 swe |
| spellingShingle | Animal physiology - Reproduction Lindell, Malin Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title | Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title_full | Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title_fullStr | Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title_full_unstemmed | Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title_short | Effekten av Bisfenol A (BPA) på hanråttors (Rattus norvegicus) reproduktion |
| title_sort | effekten av bisfenol a (bpa) på hanråttors (rattus norvegicus) reproduktion |
| topic | Animal physiology - Reproduction |
| url | https://stud.epsilon.slu.se/8028/ https://stud.epsilon.slu.se/8028/ |