Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar
The effects of dexmedetomidine and butorphanol sedation on skin reactivity during intradermal testing in healthy dogs were evaluated. The effects of dexmedetomidine and butorphanol were compared to medetomidine, a sedative agent having scientific proof of not interfering with skin test reactivity, i...
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| Format: | L3 |
| Language: | Swedish Inglés |
| Published: |
SLU/Dept. of Clinical Sciences (until 231231)
2010
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| Subjects: |
| _version_ | 1855570224720379904 |
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| author | Dahlheim, Anna |
| author_browse | Dahlheim, Anna |
| author_facet | Dahlheim, Anna |
| author_sort | Dahlheim, Anna |
| collection | Epsilon Archive for Student Projects |
| description | The effects of dexmedetomidine and butorphanol sedation on skin reactivity during intradermal testing in healthy dogs were evaluated. The effects of dexmedetomidine and butorphanol were compared to medetomidine, a sedative agent having scientific proof of not interfering with skin test reactivity, in a randomised, double blind, cross over study performed on 8 adult dogs.
The dogs were sedated with medetomidine (Domitor vet.®, 0,01 ml kg-1) intravenously, or dexmedetomidine and butorphanol intramuscularly (Dexdomitor vet.®, 0,01 ml kg-1; Dolorex vet., 0,01 ml kg-1) after which they received intradermal injections of positive control solutions (histamine 0,1 mg ml-1, 0,05 mg ml-1, 0,025 mg ml-1), a negative control solution (0,9 % NaCl) and allergen extract (Dermatophagoides farinae, Cladosporium and Artemisia vulgaris). After a wash out period the trial was repeated with a reversed sedation protocol.
Skin reactivity (wheal size, induration and erythema) and quality of sedation (immobilization, response to stimuli and injections as well as over all working conditions) were evaluated.
The combination of dexmedetomidine and butorphanol provided reliable, good sedation and analgesia without adverse effects. The study indicates that dexmedetomidine and butorphanol do not affect skin reactivity during intradermal testing in healthy dogs. In addition, only minor response to stimuli was noticed with dexmedetomidine and butorphanol and the combination provided immobilization superior to medetomidine sedation, thus better over all working conditions during intradermal testing compared to medetomidine. The study results indicate that dexmedetomidine and butorphanol sedation is very suitable for intradermal testing in dogs. |
| format | L3 |
| id | RepoSLU775 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | SLU/Dept. of Clinical Sciences (until 231231) |
| publisherStr | SLU/Dept. of Clinical Sciences (until 231231) |
| record_format | eprints |
| spelling | RepoSLU7752012-04-20T14:10:54Z Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar Effects of dexmedetomidine and butorphanol sedation on intradermal test reactivity in healthy dogs Dahlheim, Anna Hund Allergi Atopisk dermatit Atopi Intradernaltest Sedering Dexmedetomidin Butorfanol The effects of dexmedetomidine and butorphanol sedation on skin reactivity during intradermal testing in healthy dogs were evaluated. The effects of dexmedetomidine and butorphanol were compared to medetomidine, a sedative agent having scientific proof of not interfering with skin test reactivity, in a randomised, double blind, cross over study performed on 8 adult dogs. The dogs were sedated with medetomidine (Domitor vet.®, 0,01 ml kg-1) intravenously, or dexmedetomidine and butorphanol intramuscularly (Dexdomitor vet.®, 0,01 ml kg-1; Dolorex vet., 0,01 ml kg-1) after which they received intradermal injections of positive control solutions (histamine 0,1 mg ml-1, 0,05 mg ml-1, 0,025 mg ml-1), a negative control solution (0,9 % NaCl) and allergen extract (Dermatophagoides farinae, Cladosporium and Artemisia vulgaris). After a wash out period the trial was repeated with a reversed sedation protocol. Skin reactivity (wheal size, induration and erythema) and quality of sedation (immobilization, response to stimuli and injections as well as over all working conditions) were evaluated. The combination of dexmedetomidine and butorphanol provided reliable, good sedation and analgesia without adverse effects. The study indicates that dexmedetomidine and butorphanol do not affect skin reactivity during intradermal testing in healthy dogs. In addition, only minor response to stimuli was noticed with dexmedetomidine and butorphanol and the combination provided immobilization superior to medetomidine sedation, thus better over all working conditions during intradermal testing compared to medetomidine. The study results indicate that dexmedetomidine and butorphanol sedation is very suitable for intradermal testing in dogs. SLU/Dept. of Clinical Sciences (until 231231) 2010 L3 swe eng https://stud.epsilon.slu.se/775/ |
| spellingShingle | Hund Allergi Atopisk dermatit Atopi Intradernaltest Sedering Dexmedetomidin Butorfanol Dahlheim, Anna Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title | Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title_full | Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title_fullStr | Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title_full_unstemmed | Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title_short | Effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| title_sort | effekter av sedering med dexmedetomidin och butorfanol på hudreaktivitet vid intradermaltest på friska hundar |
| topic | Hund Allergi Atopisk dermatit Atopi Intradernaltest Sedering Dexmedetomidin Butorfanol |