Flavan-3-oler och endotel -dysfunktion
Background: Flavan-3-ols are polyphenolic phytochemicals belonging to the flavonoids. Flavan-3-ols are present in many higher plants and are particularly concentrated in e.g. Camellia sinensis (tea) and Theobroma cacao (cacao) and have got attention due to their antioxidative capacity. Many studies...
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| Formato: | M2 |
| Lenguaje: | sueco Inglés |
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SLU/Dept. of Food Science
2014
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| Materias: |
| _version_ | 1855570999092707328 |
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| author | Woll, Felicia |
| author_browse | Woll, Felicia |
| author_facet | Woll, Felicia |
| author_sort | Woll, Felicia |
| collection | Epsilon Archive for Student Projects |
| description | Background: Flavan-3-ols are polyphenolic phytochemicals belonging to the flavonoids. Flavan-3-ols are present in many higher plants and are particularly concentrated in e.g. Camellia sinensis (tea) and Theobroma cacao (cacao) and have got attention due to their antioxidative capacity. Many studies have been able to associate flavan-3-ol-rich foods to improved endothelial function. The aim of the present work is to review the scientific literature and evaluate the evidence for positive effects of flavan-3-ols on endothelial dysfunction in humans.
Method: Scientific articles describing intervention and observational studies about flavan-3-ols and endothelial dysfunction, were searched for on http://www.pubmed.org.
Results: Ten out of ten intervention studies show that green and black tea and cacao products affect typical biomarkers for endothelial dysfunction and improve the endothelial dependent vasodilatation and endothelial dysfunction, with acute and long term effects. Observational studies show that flavan-3-olrich are associated with a reduced risk for type 2 diabetes and a reduced risk for CVDs such as myocardial infarction after adjustment for established confounders.
Conclusion: Flavan-3-ol rich food appears to have a positive effect on endothelial dysfunction and the effects may be attributed to the flavan-3-ols per see. |
| format | M2 |
| id | RepoSLU6374 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | SLU/Dept. of Food Science |
| publisherStr | SLU/Dept. of Food Science |
| record_format | eprints |
| spelling | RepoSLU63742014-03-18T13:50:52Z Flavan-3-oler och endotel -dysfunktion Flavan-3-ols and endothelial dysfunction Woll, Felicia Endotel -dysfunktion Flavan-3-oler FMD Camellia sinensis Theobroma cacao Background: Flavan-3-ols are polyphenolic phytochemicals belonging to the flavonoids. Flavan-3-ols are present in many higher plants and are particularly concentrated in e.g. Camellia sinensis (tea) and Theobroma cacao (cacao) and have got attention due to their antioxidative capacity. Many studies have been able to associate flavan-3-ol-rich foods to improved endothelial function. The aim of the present work is to review the scientific literature and evaluate the evidence for positive effects of flavan-3-ols on endothelial dysfunction in humans. Method: Scientific articles describing intervention and observational studies about flavan-3-ols and endothelial dysfunction, were searched for on http://www.pubmed.org. Results: Ten out of ten intervention studies show that green and black tea and cacao products affect typical biomarkers for endothelial dysfunction and improve the endothelial dependent vasodilatation and endothelial dysfunction, with acute and long term effects. Observational studies show that flavan-3-olrich are associated with a reduced risk for type 2 diabetes and a reduced risk for CVDs such as myocardial infarction after adjustment for established confounders. Conclusion: Flavan-3-ol rich food appears to have a positive effect on endothelial dysfunction and the effects may be attributed to the flavan-3-ols per see. Bakgrund: Flavan-3-oler är polyfenoliska fytokemikalier tillhörandes flavonoiderna. Flavan-3-oler finns i de flesta högre växter och är särskilt koncentrerade i t.ex. Camellia sinensis (te) och Theobrma cacao (kakao) och har fått mycket uppmärksamhet p.g.a deras antioxidativa kapacitet. Ett flertal studier har pekat på ett samband mellan flava-3-olrika livsmedel och förbättrad endotelfunktion. Syftet med denna litteraturstudie är att sammanfatta vetenskapligt underlag och utvärdera bevis avseende flavan-3-olers positiva effekter på endotel -dysfunktion hos människor. Metod: Vetenskapliga artiklar beskrivande interventions- och observationsstudier avseende flavan-3-oler och endotel -dysfunktion söktes på databasen http://www.pubmed.org. Resultat: Tio av tio interventionsstudier visar att grönt och svart te och kakaoprodukter påverkar typiska biomarkörer för endotel -dysfunktion och förbättrar den endotelberoende vasodilateringen och endotel -dysfunktion, akut och på kort och lång sikt. Observationsstudier visar att flavan-3-olrika livsmedel kan kopplas till en reducerad risk för typ 2 diabetes och för CVDs så som hjärtinfarkt. Slutsats: Flavan-3-olrika livsmedel har en positiv effekt på endotel -dysfunktion. SLU/Dept. of Food Science 2014 M2 swe eng https://stud.epsilon.slu.se/6374/ |
| spellingShingle | Endotel -dysfunktion Flavan-3-oler FMD Camellia sinensis Theobroma cacao Woll, Felicia Flavan-3-oler och endotel -dysfunktion |
| title | Flavan-3-oler och endotel -dysfunktion |
| title_full | Flavan-3-oler och endotel -dysfunktion |
| title_fullStr | Flavan-3-oler och endotel -dysfunktion |
| title_full_unstemmed | Flavan-3-oler och endotel -dysfunktion |
| title_short | Flavan-3-oler och endotel -dysfunktion |
| title_sort | flavan-3-oler och endotel -dysfunktion |
| topic | Endotel -dysfunktion Flavan-3-oler FMD Camellia sinensis Theobroma cacao |