The role of FGFs in the elicitation of different cellular responses
Fibroblast growth factors are signaling peptides that controls important cellular processes such as proliferation, differentiation, migration, adhesion and survival. Through binding to different types of receptors on the cell surface, these peptides can have different effect on the target cell. Whic...
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| Formato: | M2 |
| Lenguaje: | Inglés sueco |
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SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231)
2013
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| Materias: |
| _version_ | 1855570955083972608 |
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| author | Laestander, Caroline |
| author_browse | Laestander, Caroline |
| author_facet | Laestander, Caroline |
| author_sort | Laestander, Caroline |
| collection | Epsilon Archive for Student Projects |
| description | Fibroblast growth factors are signaling peptides that controls important cellular processes such as proliferation, differentiation, migration, adhesion and survival. Through binding to different types of receptors on the cell surface, these peptides can have different effect on the target cell. Which effect that is achieved depends on many factors. Thus, each of the 24 known FGFs different biological responses. The FGF receptors (FGFR 1-4) initiates different intracellular pathways which in turn leads to different biological responses. The FGFs also binds different FGFs with different affinities. Finally, different types of cells express the FGFRs in different patterns and in altered extent which also affects the response. To summarize it, the response from a FGF depends on the combination of FGF, receptor and the type of cell that collaborate. |
| format | M2 |
| id | RepoSLU6096 |
| institution | Swedish University of Agricultural Sciences |
| language | Inglés swe |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) |
| publisherStr | SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) |
| record_format | eprints |
| spelling | RepoSLU60962013-09-26T11:09:55Z The role of FGFs in the elicitation of different cellular responses Fibroblastlika tillväxtfaktorer, deras receptorer och biologiska effekter Laestander, Caroline FGF fibroblast growth factor FGF receptor cellular effects diversity cellular responses proliferation migration Fibroblast growth factors are signaling peptides that controls important cellular processes such as proliferation, differentiation, migration, adhesion and survival. Through binding to different types of receptors on the cell surface, these peptides can have different effect on the target cell. Which effect that is achieved depends on many factors. Thus, each of the 24 known FGFs different biological responses. The FGF receptors (FGFR 1-4) initiates different intracellular pathways which in turn leads to different biological responses. The FGFs also binds different FGFs with different affinities. Finally, different types of cells express the FGFRs in different patterns and in altered extent which also affects the response. To summarize it, the response from a FGF depends on the combination of FGF, receptor and the type of cell that collaborate. Fibroblastlika tillväxtfaktorer är proteinhormoner som styr viktiga cellulära processer som till exempel proliferation, differentiering, migration, adhesion och överlevnad. Genom att binda till olika typer av membranbundna receptorer kan dessa peptider utöva olika effekter på målcellen. Vilka effekter de ger upphov till har olika förklaringsgrunder. Sålunda ger var och en av de 24 hittills kända FGF-varianterna delvis olika biologiska svar. Dessutom initierar olika receptorer (ffa FGF-R 1-4) olika intracellulära signalvägar som i sin tur ger upphov till olika biologiska sluteffekter. Receptorerna binder olika FGF–ligander med olika affinitet. Slutligen har olika målceller olika receptoruppsättningar vilket i sin tur påverkar det slutliga svaret. Således samspelar själva tillväxtfaktorerna med olika receptorer, med olika affinitetsegenskaper, som uttrycks i olika relativa tal på olika cellslag. Vilket biologiskt svar som utlöses beror på vilken kombination av fibroblastlik tillväxtfaktor, receptor och celltyp som samverkar. SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) 2013 M2 eng swe https://stud.epsilon.slu.se/6096/ |
| spellingShingle | FGF fibroblast growth factor FGF receptor cellular effects diversity cellular responses proliferation migration Laestander, Caroline The role of FGFs in the elicitation of different cellular responses |
| title | The role of FGFs in the elicitation of different cellular responses |
| title_full | The role of FGFs in the elicitation of different cellular responses |
| title_fullStr | The role of FGFs in the elicitation of different cellular responses |
| title_full_unstemmed | The role of FGFs in the elicitation of different cellular responses |
| title_short | The role of FGFs in the elicitation of different cellular responses |
| title_sort | role of fgfs in the elicitation of different cellular responses |
| topic | FGF fibroblast growth factor FGF receptor cellular effects diversity cellular responses proliferation migration |