Teratology in zebrafish embryos
Teratology, study of abnormal prenatal development, as a descriptive science has starts with written language. The modern experimental teratology era started in the early quarter of 20th centaury. Since the thalidomide catastrophe in early 1960s regulatory agencies launched requirements for new drug...
| Autor principal: | |
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| Formato: | Second cycle, A1N, A1F or AXX |
| Lenguaje: | Inglés Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://stud.epsilon.slu.se/3337/ |
| _version_ | 1855570554487046144 |
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| author | Ali, Nadeem |
| author_browse | Ali, Nadeem |
| author_facet | Ali, Nadeem |
| author_sort | Ali, Nadeem |
| collection | Epsilon Archive for Student Projects |
| description | Teratology, study of abnormal prenatal development, as a descriptive science has starts with written language. The modern experimental teratology era started in the early quarter of 20th centaury. Since the thalidomide catastrophe in early 1960s regulatory agencies launched requirements for new drugs to be thoroughly tested on animals prior
to human use. One of the major concerns in the teratological studies is the mechanism of teratogenesis; it is very difficult to know the exact mechanism of teratogenesis. However there are many proposed
mechanism of teratogenesis by Wilson 1973. Teratogens induce one or multiple unique pathogenic responses in the developing embryos. Susceptibility f teratogenesis varies with age and therefore can be divided into three developmental periods: early embryonic
development, organogenesis and early differentiation, and late embryonic development. Animal based studies provide the initial guideline if a chemical or drug may present a teratogenic risk. A variety of laboratory animals
from different classes of animals are being used for the teratological studies. Rat, rabbit, mice, hamster, and non human primates are the most prevalent laboratory animal species of the mammal class. Xenopus laevis of the amphibian class has been used and suggested as
a model for mammalian teratogenicity. From the bird class chicken, duck and quail have been used most often in laboratory studies. Zebrafish, Japanese medaka and fathead minnow are the most commonly used laboratory fish species, promoted by OECD for future testing of chemical toxicity. Teratogens can be classified as recreational and social teratogens, pharmaceutical teratogens, industrial and environmental teratogens, agricultural teratogens, and
metabolic and infectious diseases. In the present study model substances were selected from the different classes of teratogens. The selected substances were; retinoic acid, lithium, ethanol, 6-aminonicotinamide, ochratoxin A and arsenic, |
| format | Second cycle, A1N, A1F or AXX |
| id | RepoSLU3337 |
| institution | Swedish University of Agricultural Sciences |
| language | Inglés Inglés |
| publishDate | 2011 |
| publishDateSort | 2011 |
| record_format | eprints |
| spelling | RepoSLU33372012-04-20T14:22:51Z https://stud.epsilon.slu.se/3337/ Teratology in zebrafish embryos Ali, Nadeem Animal diseases Teratology, study of abnormal prenatal development, as a descriptive science has starts with written language. The modern experimental teratology era started in the early quarter of 20th centaury. Since the thalidomide catastrophe in early 1960s regulatory agencies launched requirements for new drugs to be thoroughly tested on animals prior to human use. One of the major concerns in the teratological studies is the mechanism of teratogenesis; it is very difficult to know the exact mechanism of teratogenesis. However there are many proposed mechanism of teratogenesis by Wilson 1973. Teratogens induce one or multiple unique pathogenic responses in the developing embryos. Susceptibility f teratogenesis varies with age and therefore can be divided into three developmental periods: early embryonic development, organogenesis and early differentiation, and late embryonic development. Animal based studies provide the initial guideline if a chemical or drug may present a teratogenic risk. A variety of laboratory animals from different classes of animals are being used for the teratological studies. Rat, rabbit, mice, hamster, and non human primates are the most prevalent laboratory animal species of the mammal class. Xenopus laevis of the amphibian class has been used and suggested as a model for mammalian teratogenicity. From the bird class chicken, duck and quail have been used most often in laboratory studies. Zebrafish, Japanese medaka and fathead minnow are the most commonly used laboratory fish species, promoted by OECD for future testing of chemical toxicity. Teratogens can be classified as recreational and social teratogens, pharmaceutical teratogens, industrial and environmental teratogens, agricultural teratogens, and metabolic and infectious diseases. In the present study model substances were selected from the different classes of teratogens. The selected substances were; retinoic acid, lithium, ethanol, 6-aminonicotinamide, ochratoxin A and arsenic, 2011-10-28 Second cycle, A1N, A1F or AXX NonPeerReviewed application/pdf eng https://stud.epsilon.slu.se/3337/1/ali_n_111012.pdf Ali, Nadeem, 2007. Teratology in zebrafish embryos : a tool for risk assessment. Second cycle, A1N, A1F or AXX ( AXX). Uppsala: (VH) > Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-713.html> urn:nbn:se:slu:epsilon-s-670 eng |
| spellingShingle | Animal diseases Ali, Nadeem Teratology in zebrafish embryos |
| title | Teratology in zebrafish
embryos |
| title_full | Teratology in zebrafish
embryos |
| title_fullStr | Teratology in zebrafish
embryos |
| title_full_unstemmed | Teratology in zebrafish
embryos |
| title_short | Teratology in zebrafish
embryos |
| title_sort | teratology in zebrafish
embryos |
| topic | Animal diseases |
| url | https://stud.epsilon.slu.se/3337/ https://stud.epsilon.slu.se/3337/ |