Expression of influenza virus nonstructural protein 1 (NS1)
Avian influenza poses a threat to many species including man, as shown by the current scenario in Southeast Asia. It appears that this particular type of influenza virus can spread to many species causing severe disease in these new species. For example, from 258 human cases 154 were fatal (WHO, 200...
| Autor principal: | |
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| Formato: | Second cycle, A1N, A1F or AXX |
| Lenguaje: | Inglés Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://stud.epsilon.slu.se/3331/ |
| _version_ | 1855570553210929152 |
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| author | Metreveli, Giorgi |
| author_browse | Metreveli, Giorgi |
| author_facet | Metreveli, Giorgi |
| author_sort | Metreveli, Giorgi |
| collection | Epsilon Archive for Student Projects |
| description | Avian influenza poses a threat to many species including man, as shown by the current scenario in Southeast Asia. It appears that this particular type of influenza
virus can spread to many species causing severe disease in these new species. For example, from 258 human cases 154 were fatal (WHO, 2006-11-29). Why some avian influenza virus have the ability to infect other species remains to be
understood. One viral gene, coding for the non-structural protein 1 (NS1), appears to be an important factor for successfully transmission into a new host, by counteracting
the new host’s immune system. The exact mechanism of action of NS1 is still unclear, but leads to down-regulation of various pathways of the immune defence. The aim of this study was to express NS1 proteins of influenza viruses
originating from different hosts, including highly pathogenic avian influenza viruses, for use in investigations on the mechanism used by NS1 to interfere with the immune system of various hosts. In particular, studies on the interaction of NS1 with the RNA dependent protein kinase (PKR) were initiated, to determine
differences in this interaction between high and low pathogenic influenza viruses from different hosts. By establishing tools and optimised assays, the work enables
further studies on the role NS1 in immune evasion. |
| format | Second cycle, A1N, A1F or AXX |
| id | RepoSLU3331 |
| institution | Swedish University of Agricultural Sciences |
| language | Inglés Inglés |
| publishDate | 2011 |
| publishDateSort | 2011 |
| record_format | eprints |
| spelling | RepoSLU33312012-04-20T14:22:49Z https://stud.epsilon.slu.se/3331/ Expression of influenza virus nonstructural protein 1 (NS1) Metreveli, Giorgi Animal diseases Human medicine, health, and safety Avian influenza poses a threat to many species including man, as shown by the current scenario in Southeast Asia. It appears that this particular type of influenza virus can spread to many species causing severe disease in these new species. For example, from 258 human cases 154 were fatal (WHO, 2006-11-29). Why some avian influenza virus have the ability to infect other species remains to be understood. One viral gene, coding for the non-structural protein 1 (NS1), appears to be an important factor for successfully transmission into a new host, by counteracting the new host’s immune system. The exact mechanism of action of NS1 is still unclear, but leads to down-regulation of various pathways of the immune defence. The aim of this study was to express NS1 proteins of influenza viruses originating from different hosts, including highly pathogenic avian influenza viruses, for use in investigations on the mechanism used by NS1 to interfere with the immune system of various hosts. In particular, studies on the interaction of NS1 with the RNA dependent protein kinase (PKR) were initiated, to determine differences in this interaction between high and low pathogenic influenza viruses from different hosts. By establishing tools and optimised assays, the work enables further studies on the role NS1 in immune evasion. 2011-10-26 Second cycle, A1N, A1F or AXX NonPeerReviewed application/pdf eng https://stud.epsilon.slu.se/3331/1/metreveli_g_111012.pdf Metreveli, Giorgi, 2006. Expression of influenza virus nonstructural protein 1 (NS1). Second cycle, A1N, A1F or AXX ( AXX). Uppsala: (VH) > Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-713.html> urn:nbn:se:slu:epsilon-s-657 eng |
| spellingShingle | Animal diseases Human medicine, health, and safety Metreveli, Giorgi Expression of influenza virus nonstructural protein 1 (NS1) |
| title | Expression of influenza virus nonstructural
protein 1 (NS1) |
| title_full | Expression of influenza virus nonstructural
protein 1 (NS1) |
| title_fullStr | Expression of influenza virus nonstructural
protein 1 (NS1) |
| title_full_unstemmed | Expression of influenza virus nonstructural
protein 1 (NS1) |
| title_short | Expression of influenza virus nonstructural
protein 1 (NS1) |
| title_sort | expression of influenza virus nonstructural
protein 1 (ns1) |
| topic | Animal diseases Human medicine, health, and safety |
| url | https://stud.epsilon.slu.se/3331/ https://stud.epsilon.slu.se/3331/ |