Breast cancer stem cells
This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of...
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| Formato: | First cycle, G2E |
| Lenguaje: | sueco Inglés |
| Publicado: |
2011
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| Acceso en línea: | https://stud.epsilon.slu.se/2650/ |
| _version_ | 1855570462263738368 |
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| author | Rydhed, Erica |
| author_browse | Rydhed, Erica |
| author_facet | Rydhed, Erica |
| author_sort | Rydhed, Erica |
| collection | Epsilon Archive for Student Projects |
| description | This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of the tumour cannot. These tumour initiating cells have shown to possess many characteristics similar to those of adult stem cells, which is why they are often referred to as cancer stem cells. Both cell types have the capacity of asymmetric division and have shown to possess mechanisms of resistance to both apoptosis and cancer drugs. The cancer stem cell theory elucidates many biological aspects such as the heterogeneity of tumours and the relapse of many cancers after what appeared to be successful treatments. In the last decade, the first putative breast cancer stem cells were identified and further research was made which strengthened the relevance of the theory. Different markers have been used to identify the breast cancer stem cells and their tumour initiating capacity has been examined both in vitro and in vivo. However, recent studies on the existence and frequency of breast cancer stem cells have had varying results. The interpretation of these results is complicated by the difficulties in establishing a correct micro environment and the different techniques used when separating and identifying the breast cancer stem cells. There is a need for further research on the existence of breast cancer stem cells and their clinical relevance. |
| format | First cycle, G2E |
| id | RepoSLU2650 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2011 |
| publishDateSort | 2011 |
| record_format | eprints |
| spelling | RepoSLU26502012-04-20T14:19:40Z https://stud.epsilon.slu.se/2650/ Breast cancer stem cells Rydhed, Erica Animal physiology and biochemistry Human medicine, health, and safety This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of the tumour cannot. These tumour initiating cells have shown to possess many characteristics similar to those of adult stem cells, which is why they are often referred to as cancer stem cells. Both cell types have the capacity of asymmetric division and have shown to possess mechanisms of resistance to both apoptosis and cancer drugs. The cancer stem cell theory elucidates many biological aspects such as the heterogeneity of tumours and the relapse of many cancers after what appeared to be successful treatments. In the last decade, the first putative breast cancer stem cells were identified and further research was made which strengthened the relevance of the theory. Different markers have been used to identify the breast cancer stem cells and their tumour initiating capacity has been examined both in vitro and in vivo. However, recent studies on the existence and frequency of breast cancer stem cells have had varying results. The interpretation of these results is complicated by the difficulties in establishing a correct micro environment and the different techniques used when separating and identifying the breast cancer stem cells. There is a need for further research on the existence of breast cancer stem cells and their clinical relevance. Denna litteraturstudie syftar till att utreda var forskningen kring bröstcancerstamceller står idag. Enligt cancerstamcellsteorin finns i tumörer en hierarkisk organisation, där en viss subpopulation av tumörcellerna har förmågan att generera nya tumörer och underhålla tumörtillväxten, medan den resterande delen av tumörcellerna inte har denna förmåga. De tumörinitierande cellerna, ofta benämnda cancerstamceller, har visat sig ha många likheter med adulta stamceller. Bland annat har båda celltyperna förmågan att dela sig asymmetriskt, samt en utvecklad resistens mot apoptos och läkemedel. Cancerstamcellsteorin klargör många frågetecken inom cancerbiologin, såsom tumörers heterogenitet samt de många fall då tumörer återkommer efter vad som verkat vara lyckade cancerbehandlingar. I början av 2000-talet identifierades de första förmodade bröstcancerstamcellerna och ytterligare forskning inom området stärkte bevisen för deras existens. Olika markörer har använts för att identifiera bröstcancerstamcellerna och deras tumörinitierande förmåga har testats både in vitro och in vivo. Senare forskning har dock lett till varierande resultat vad gäller förekomst och frekvens av cancerstamceller i olika brösttumörer. Det finns fortfarande många brister i teknikerna som används för att identifiera och isolera bröstcancerstamceller. En stor utmaning handlar om att kunna upprätta en representativ mikromiljö för att kunna undersöka cellernas tumörinitierande förmåga. Ytterligare forskning krävs inom området innan det säkert går att klargöra huruvida cancerstamcellsteorin är applicerbar på och har klinisk relevans för bröstcancer. 2011-05-28 First cycle, G2E NonPeerReviewed application/pdf swe https://stud.epsilon.slu.se/2650/1/rydhed_e_110528.pdf Rydhed, Erica, 2011. Breast cancer stem cells : evidence and contradictory views. First cycle, G2E. Uppsala: (VH) > Dept. of Anatomy, Physiology and Biochemistry (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-712.html> urn:nbn:se:slu:epsilon-s-169 eng |
| spellingShingle | Animal physiology and biochemistry Human medicine, health, and safety Rydhed, Erica Breast cancer stem cells |
| title | Breast cancer stem cells |
| title_full | Breast cancer stem cells |
| title_fullStr | Breast cancer stem cells |
| title_full_unstemmed | Breast cancer stem cells |
| title_short | Breast cancer stem cells |
| title_sort | breast cancer stem cells |
| topic | Animal physiology and biochemistry Human medicine, health, and safety |
| url | https://stud.epsilon.slu.se/2650/ https://stud.epsilon.slu.se/2650/ |