Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning?
Thoroughbred racehorses have suffered from exercise-induced haemorrhage for over 300 years. Almost all competing horses develop exercise-induced pulmonary haemorrhage (EIPH) at some point but most horses don’t suffer from reduced competing capacity due to the disease. The cause of the exercise-induc...
| Autor principal: | |
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| Formato: | First cycle, G2E |
| Lenguaje: | sueco sueco |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://stud.epsilon.slu.se/2167/ |
| _version_ | 1855570397832937472 |
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| author | Lernö, Petra |
| author_browse | Lernö, Petra |
| author_facet | Lernö, Petra |
| author_sort | Lernö, Petra |
| collection | Epsilon Archive for Student Projects |
| description | Thoroughbred racehorses have suffered from exercise-induced haemorrhage for over 300 years. Almost all competing horses develop exercise-induced pulmonary haemorrhage (EIPH) at some point but most horses don’t suffer from reduced competing capacity due to the disease. The cause of the exercise-induced haemorrhage is unknown. The most believed theory today is that EIPH is induced by pulmonary stress failure caused by pressure over 100 mmHg in the pulmonary arteries during exercise. The hypothesis of this study is that EIPH is induced by changes in the body fluid balance and chronic metabolic and physical stress. It has been shown that racehorses suffer from endotoxemia during racing but they are also able to cope with it. The final hypothesis in this study is that due to these earlier causes the horse have problems coping with endotoxemia during race. Endotoxemia activates leucocytes, releases vasoactive and inflammatory mediators including tumour necrosis factor α (TNF-α) and interleukin β (IL-β). It furthermore increases neutrophil migration in the lung and these effects of endotoxins on stressed horses forced to maximal exercise is hypothesised to be the final cause of the bleeding and reduced racing capacity. |
| format | First cycle, G2E |
| id | RepoSLU2167 |
| institution | Swedish University of Agricultural Sciences |
| language | swe swe |
| publishDate | 2011 |
| publishDateSort | 2011 |
| record_format | eprints |
| spelling | RepoSLU21672012-04-20T14:17:21Z https://stud.epsilon.slu.se/2167/ Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? Lernö, Petra Animal feeding Animal physiology and biochemistry Animal physiology - Nutrition Veterinary science and hygiene - General aspects Animal diseases Thoroughbred racehorses have suffered from exercise-induced haemorrhage for over 300 years. Almost all competing horses develop exercise-induced pulmonary haemorrhage (EIPH) at some point but most horses don’t suffer from reduced competing capacity due to the disease. The cause of the exercise-induced haemorrhage is unknown. The most believed theory today is that EIPH is induced by pulmonary stress failure caused by pressure over 100 mmHg in the pulmonary arteries during exercise. The hypothesis of this study is that EIPH is induced by changes in the body fluid balance and chronic metabolic and physical stress. It has been shown that racehorses suffer from endotoxemia during racing but they are also able to cope with it. The final hypothesis in this study is that due to these earlier causes the horse have problems coping with endotoxemia during race. Endotoxemia activates leucocytes, releases vasoactive and inflammatory mediators including tumour necrosis factor α (TNF-α) and interleukin β (IL-β). It furthermore increases neutrophil migration in the lung and these effects of endotoxins on stressed horses forced to maximal exercise is hypothesised to be the final cause of the bleeding and reduced racing capacity. 2011-01-18 First cycle, G2E NonPeerReviewed application/pdf swe https://stud.epsilon.slu.se/2167/1/lerno_p_110331.pdf Lernö, Petra, 2011. Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning?. First cycle, G2E. Uppsala: (VH) > Dept. of Anatomy, Physiology and Biochemistry (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-712.html> urn:nbn:se:slu:epsilon-6-476 swe |
| spellingShingle | Animal feeding Animal physiology and biochemistry Animal physiology - Nutrition Veterinary science and hygiene - General aspects Animal diseases Lernö, Petra Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title | Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title_full | Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title_fullStr | Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title_full_unstemmed | Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title_short | Kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| title_sort | kan kombinationen av dehydrering, kronisk stress och/eller endotoxemi vara orsaken till träningsinducerad lungblödning? |
| topic | Animal feeding Animal physiology and biochemistry Animal physiology - Nutrition Veterinary science and hygiene - General aspects Animal diseases |
| url | https://stud.epsilon.slu.se/2167/ https://stud.epsilon.slu.se/2167/ |