Applications of phage therapy in veterinary medicine
This paper describes some different investigations of phage therapy within veterinary medicine, in treating some of the most common bacterial infections in poultry, cattle and fish. As a red thread, phage therapy is being compared and contrasted with the current standard antibiotic treatment within...
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| Formato: | M2 |
| Lenguaje: | Inglés sueco |
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SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231)
2018
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| Materias: |
| _version_ | 1855572228430626816 |
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| author | Gazeev, Sergey |
| author_browse | Gazeev, Sergey |
| author_facet | Gazeev, Sergey |
| author_sort | Gazeev, Sergey |
| collection | Epsilon Archive for Student Projects |
| description | This paper describes some different investigations of phage therapy within veterinary medicine, in treating some of the most common bacterial infections in poultry, cattle and fish. As a red thread, phage therapy is being compared and contrasted with the current standard antibiotic treatment within some common diseases, as well as in general, in the discussion section.
Bacteriophages, also known simply as phages, are bacterial (obligate) parasites or viruses that infect, replicate inside and eventually lyse their host bacterium, letting out hundreds of new phages. Since phages depend on bacteria as their host, they can be used for therapeutic purposes to help the immune system against the pathogens by killing the bacteria.
Salmonellosis is caused by Salmonella bacteria and it is one of the most common and important infections transmitted between animals and man (zoonosis). Salmonella phages proved very effective in treating mice and chicken infected with Salmonella with a success rate of 90-100% (Lenev, 2013).
Treatment of rabbits infected with Vibrio cholera by phages did not provide any successful results on the rabbit models, in contrast to the successful trial of treating cholera in humans. This is one of the examples how the effect of phage therapy application can vary within different species.
Phages have shown to be effective against Enterococcus in mice models, with the pathogen’s significant decrease under infective dose; however, a tendency has been found that the earlier the treatment started the better result was obtained.
When tested against Clostridium difficile, phages were able to protect the mice models from the disease but the effect did not endure for long. In all the different trials, it remains important to neutralise the gastric acid before administering phages orally, since low pH deactivates them.
In the aquatic sphere, the two principle diseases have been taken up – aeromonosis and pseudomonosis, where phage therapy is still in the mode of trial, but already suggested by some researchers (Kafydova and Grinyova, 2014) to be used for treatment. Phage therapy has shown significant effects on Pseudomonas pleoglossicida, and a very promising result has been demonstrated on the Lactococcus bacteria, with maximal success and absolute protection of fish against the pathogen. |
| format | M2 |
| id | RepoSLU13344 |
| institution | Swedish University of Agricultural Sciences |
| language | Inglés swe |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) |
| publisherStr | SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) |
| record_format | eprints |
| spelling | RepoSLU133442019-02-25T13:06:28Z Applications of phage therapy in veterinary medicine Fagterapi och dess tillämpning inom veterinärmedicin Gazeev, Sergey phages phage therapy bacterial infections aquaculture This paper describes some different investigations of phage therapy within veterinary medicine, in treating some of the most common bacterial infections in poultry, cattle and fish. As a red thread, phage therapy is being compared and contrasted with the current standard antibiotic treatment within some common diseases, as well as in general, in the discussion section. Bacteriophages, also known simply as phages, are bacterial (obligate) parasites or viruses that infect, replicate inside and eventually lyse their host bacterium, letting out hundreds of new phages. Since phages depend on bacteria as their host, they can be used for therapeutic purposes to help the immune system against the pathogens by killing the bacteria. Salmonellosis is caused by Salmonella bacteria and it is one of the most common and important infections transmitted between animals and man (zoonosis). Salmonella phages proved very effective in treating mice and chicken infected with Salmonella with a success rate of 90-100% (Lenev, 2013). Treatment of rabbits infected with Vibrio cholera by phages did not provide any successful results on the rabbit models, in contrast to the successful trial of treating cholera in humans. This is one of the examples how the effect of phage therapy application can vary within different species. Phages have shown to be effective against Enterococcus in mice models, with the pathogen’s significant decrease under infective dose; however, a tendency has been found that the earlier the treatment started the better result was obtained. When tested against Clostridium difficile, phages were able to protect the mice models from the disease but the effect did not endure for long. In all the different trials, it remains important to neutralise the gastric acid before administering phages orally, since low pH deactivates them. In the aquatic sphere, the two principle diseases have been taken up – aeromonosis and pseudomonosis, where phage therapy is still in the mode of trial, but already suggested by some researchers (Kafydova and Grinyova, 2014) to be used for treatment. Phage therapy has shown significant effects on Pseudomonas pleoglossicida, and a very promising result has been demonstrated on the Lactococcus bacteria, with maximal success and absolute protection of fish against the pathogen. Denna uppsats beskriver några olika undersökningar av fagbehandling inom veterinärmedicin, inom några av de vanligaste bakterieinfektionerna hos fjäderfä, boskap och fisk. Som en röd tråd jämförs fagterapi med den aktuella antibiotikabehandlingen inom några vanliga sjukdomar samt allmänt i diskussionsdelen. Bakteriofager, även kända som fager, är bakteriella (obligata) parasiter eller virus som infekterar, replikerar inuti och så småningom lyserar deras bakterievärdar och släpper ut hundratals nya fager. Eftersom fager är beroende av bakterier som värdar, kan de användas för terapeutiska ändamål för att hjälpa immunsystemet mot patogenerna, genom att avdöda bakterierna. Salmonellos orsakas av Salmonella-bakterier och det är en av de vanligaste och viktigaste infektionerna mellan djur och människor (zoonos). Salmonellafager visade sig vara mycket effektiva vid behandling av möss och kaniner, infekterade med salmonella, med en framgångsgrad på 90-100% (Lenev, 2013). Fagbehandling av kaniner infekterade med Vibrio cholera gav inga framgångsrika resultat på kaninmodellerna, i motsats till det framgångsrika försöket att behandla kolera hos människor. Detta är ett exempel på hur fagbehandlingseffekt kan variera inom olika arter. Fager har visat sig vara effektiva mot Enterococcus i mössmodeller, med patogenens signifikanta minskning under infektionsdos; emellertid, har man hittad en tendens: ju tidigare behandlingen började, desto bättre resultat erhölls. När fager testades mot Clostridium difficile, kunde fager skydda musmodellerna från sjukdomen, men effekten varade inte länge. I de olika försöken är det viktigt att neutralisera magsyran före administrering av fager oralt, eftersom lågt pH deaktiverar dem. I akvatiska världen har de två principiella sjukdomarna upptagits - aeromonos och pseudomonos, där fagbehandling fortfarande är i provtillståndet, men som redan föreslagits av vissa forskare (Kafydova och Grinyova, 2014) som en alternativ behandling. Fagterapi har visat signifikanta effekter på Pseudomonas pleoglossicida, och ett mycket lovande resultat har visats på Lactococcus-bakterierna, med maximal framgång och absolut skydd av fisk mot patogenen. SLU/Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) 2018 M2 eng swe https://stud.epsilon.slu.se/13344/ |
| spellingShingle | phages phage therapy bacterial infections aquaculture Gazeev, Sergey Applications of phage therapy in veterinary medicine |
| title | Applications of phage therapy in veterinary medicine |
| title_full | Applications of phage therapy in veterinary medicine |
| title_fullStr | Applications of phage therapy in veterinary medicine |
| title_full_unstemmed | Applications of phage therapy in veterinary medicine |
| title_short | Applications of phage therapy in veterinary medicine |
| title_sort | applications of phage therapy in veterinary medicine |
| topic | phages phage therapy bacterial infections aquaculture |