Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study
Mice constitute more than half of all the laboratory animals used in the world. The use of transgenic mice has greatly increased during the last years. To determine their genetic setup a tailbiopsy is often taken and the question arises whether this is a painful procedure that requires anaesthesia a...
| Autor principal: | |
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| Formato: | L3 |
| Lenguaje: | Inglés sueco |
| Publicado: |
SLU/Dept. of Large Animal Clinical Sciences
2004
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| Materias: |
| _version_ | 1855572126232215552 |
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| author | Puustinen, Katja |
| author_browse | Puustinen, Katja |
| author_facet | Puustinen, Katja |
| author_sort | Puustinen, Katja |
| collection | Epsilon Archive for Student Projects |
| description | Mice constitute more than half of all the laboratory animals used in the world. The use of transgenic mice has greatly increased during the last years. To determine their genetic setup a tailbiopsy is often taken and the question arises whether this is a painful procedure that requires anaesthesia and/or analgesia. The tailtip of the mouse contains bone and skin and the periosteum is well supplied with nervous tissue. Today there are no recommendations from the Swedish National Board for Laboratory Animals about anaesthesia or analgesia in conjunction with the tailbiopsy. To evaluate the effects of tail biopsy on behaviour of mice, an automatic system for behaviour recognition was used. Differences were found between these mice and control mice and these differences might be caused by pain or discomfort. |
| format | L3 |
| id | RepoSLU12762 |
| institution | Swedish University of Agricultural Sciences |
| language | Inglés swe |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | SLU/Dept. of Large Animal Clinical Sciences |
| publisherStr | SLU/Dept. of Large Animal Clinical Sciences |
| record_format | eprints |
| spelling | RepoSLU127622017-10-19T08:23:37Z Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study Utvärdering av svansbiopsins påverkan på mössens beteende och välfärd Puustinen, Katja mice mouse tail biopsy behaviour pain wellbeing anaesthesia analgesia LABORAS Mice constitute more than half of all the laboratory animals used in the world. The use of transgenic mice has greatly increased during the last years. To determine their genetic setup a tailbiopsy is often taken and the question arises whether this is a painful procedure that requires anaesthesia and/or analgesia. The tailtip of the mouse contains bone and skin and the periosteum is well supplied with nervous tissue. Today there are no recommendations from the Swedish National Board for Laboratory Animals about anaesthesia or analgesia in conjunction with the tailbiopsy. To evaluate the effects of tail biopsy on behaviour of mice, an automatic system for behaviour recognition was used. Differences were found between these mice and control mice and these differences might be caused by pain or discomfort. Möss utgör mer än hälften av alla djur som används till forskning. Andelen transgena möss som används i djurförsök har ökat under de senaste åren. För att ta reda på deras genuppsättning tas ett vävnadsprov från svansen och frågan uppstår huruvida detta är ett smärtsamt ingrepp som kräver anestesi och/eller analgesi. Musens svansspets innehåller ben, periost och hud. Periostet är rikligt innerverat med nerver. Idag saknas svenska rekommendationer om anestesi eller analgesi i samband med svansbiopsi. För att utvärdera effekter på beteendet hos möss från vilka ett vävnadsprov tagits, användes ett automatiserat system för beteendestudier. Skillnader påvisades mellan dessa möss och kontrollmöss, vilka kan ha orsakats av smärta eller obehag. SLU/Dept. of Large Animal Clinical Sciences 2004 L3 eng swe https://stud.epsilon.slu.se/12762/ |
| spellingShingle | mice mouse tail biopsy behaviour pain wellbeing anaesthesia analgesia LABORAS Puustinen, Katja Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title | Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title_full | Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title_fullStr | Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title_full_unstemmed | Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title_short | Evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| title_sort | evaluation of the tail biopsy procedure on the behaviour and wellbeing of mice : a pilot study |
| topic | mice mouse tail biopsy behaviour pain wellbeing anaesthesia analgesia LABORAS |