Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner
Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an estimated incidence of 3-6 cases per 100 000 inhabitants in Sweden. There is no cure for the disease, which inevitably leads to death. A similar disease has been found among terrier dogs, with an especially high prevalen...
| Autor principal: | |
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| Formato: | L3 |
| Lenguaje: | sueco Inglés |
| Publicado: |
SLU/Dept. of Anatomy, Physiology and Biochemistry (until 231231)
2008
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| Materias: |
| _version_ | 1855571991931650048 |
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| author | Eriksson, Maria |
| author_browse | Eriksson, Maria |
| author_facet | Eriksson, Maria |
| author_sort | Eriksson, Maria |
| collection | Epsilon Archive for Student Projects |
| description | Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an
estimated incidence of 3-6 cases per 100 000 inhabitants in Sweden. There is no
cure for the disease, which inevitably leads to death. A similar disease has been
found among terrier dogs, with an especially high prevalence in the West
Highland White Terrier (WHWT). Dogs with pulmonary fibrosis become
lethargic with exercise intolerance, and in some cases they develop cough and
respiratory distress. This thesis gives a brief review of the field of pulmonary
fibrosis and presents a method for analyzing surfactant proteins in
bronchoalveolar lavage (BAL) in the dog. Five cases of canine pulmonary fibrosis
are presented with clinical data, histopathology and surfactant analysis. The
results show that one of the dogs with pulmonary fibrosis lacks detectable
surfactant protein C (SP-C) levels in BAL, which also has been shown in humans
diagnosed with a familiar form of IPF. |
| format | L3 |
| id | RepoSLU12057 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2008 |
| publishDateSort | 2008 |
| publisher | SLU/Dept. of Anatomy, Physiology and Biochemistry (until 231231) |
| publisherStr | SLU/Dept. of Anatomy, Physiology and Biochemistry (until 231231) |
| record_format | eprints |
| spelling | RepoSLU120572017-11-08T12:34:46Z Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner Eriksson, Maria lungfibros IPF Westie West Highland White Terrier surfaktant SP-C surfaktant protein C histopatologi lunga fibros respiration Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an estimated incidence of 3-6 cases per 100 000 inhabitants in Sweden. There is no cure for the disease, which inevitably leads to death. A similar disease has been found among terrier dogs, with an especially high prevalence in the West Highland White Terrier (WHWT). Dogs with pulmonary fibrosis become lethargic with exercise intolerance, and in some cases they develop cough and respiratory distress. This thesis gives a brief review of the field of pulmonary fibrosis and presents a method for analyzing surfactant proteins in bronchoalveolar lavage (BAL) in the dog. Five cases of canine pulmonary fibrosis are presented with clinical data, histopathology and surfactant analysis. The results show that one of the dogs with pulmonary fibrosis lacks detectable surfactant protein C (SP-C) levels in BAL, which also has been shown in humans diagnosed with a familiar form of IPF. Lungfibros, eller idiopathic pulmonary fibrosis (IPF) är en kronisk lungsjukdom som drabbar människa med en uppskattad incidens av 3-6 fall per 100 000 invånare i Sverige. Inget botemedel finns mot sjukdomen som i samtliga fall leder till döden. En liknande sjukdom har noterats hos terrierhundar med allra högst prevalens hos rasen West Highland White Terrier (WHWT). Hundar med lungfibros blir tröttare än vanligt och ovilliga att leka eller gå på promenad. Ibland utvecklar de också hosta och uttalade respiratoriska problem. Detta arbete ger en översiktlig sammanfattning av området lungfibros samt beskriver en metod för att analysera surfaktantproteiner i bronkoalveolärt lavage (BAL) hos hund. Fem fall av lungfibros hos hund presenteras med kliniska fynd, histopatologi samt surfaktantanalys. Resultaten visar att en av hundarna med lungfibros saknar detekterbart surfaktant protein C (SP-C) i postmortalt BAL, något som också påvisats hos människor med en familjär form av IPF. SLU/Dept. of Anatomy, Physiology and Biochemistry (until 231231) 2008 L3 swe eng https://stud.epsilon.slu.se/12057/ |
| spellingShingle | lungfibros IPF Westie West Highland White Terrier surfaktant SP-C surfaktant protein C histopatologi lunga fibros respiration Eriksson, Maria Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title | Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title_full | Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title_fullStr | Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title_full_unstemmed | Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title_short | Lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| title_sort | lungfibros hos hund : fallbeskrivningar, histopatologi samt analys av surfaktantproteiner |
| topic | lungfibros IPF Westie West Highland White Terrier surfaktant SP-C surfaktant protein C histopatologi lunga fibros respiration |