Restriktiv kardiomyopati hos en familj birmakatter
Cardiomyopathy is the most common type of cardiac disease in the cat. Restrictive cardiomyopathy (RCM) is comparably uncommon and only a few studies have been conducted in this disease. The purpose of this study was to examine the presence and inheritance pattern of RCM in a family of Birman cats. T...
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| Formato: | Otro |
| Lenguaje: | sueco sueco |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://stud.epsilon.slu.se/11815/ |
| _version_ | 1855571945191374848 |
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| author | Ekman, Emma |
| author_browse | Ekman, Emma |
| author_facet | Ekman, Emma |
| author_sort | Ekman, Emma |
| collection | Epsilon Archive for Student Projects |
| description | Cardiomyopathy is the most common type of cardiac disease in the cat. Restrictive cardiomyopathy (RCM) is comparably uncommon and only a few studies have been conducted in this disease. The purpose of this study was to examine the presence and inheritance pattern of RCM in a family of Birman cats. The family comprised 177 known cats. 107 of these cats were examined by echocardiography, 23 of the cats died/were euthanized and a diagnosis could be established post mortem. Out of the examined cats, 18 were diagnosed with RCM, 4 of them with strong suspicion of RCM, 10 equivocals (borderline cases), 4 with HCM, and 2 with aortic stenosis. Remaining cats were classified as free from cardiac disease at the time of examination. The age of diseased cats were between 10 months and 9 years. No sex predilection could be observed. The study indicates that genetic factors contribute to disease development. The mode of inheritance could not be fully characterized, but a dominant mode of inheritance could most certainly be ruled out. The results suggest a recessive inheritance pattern, possibly with codominance or incomplete penetrance. In absence of a gene test, breeding should be avoided in diseased individuals and their siblings, offspring and parents. Breeding should be sparse in cases where RCM has not been confirmed but suspicious signs are present. |
| format | Otro |
| id | RepoSLU11815 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish swe |
| publishDate | 2009 |
| publishDateSort | 2009 |
| record_format | eprints |
| spelling | RepoSLU118152017-10-16T11:35:57Z https://stud.epsilon.slu.se/11815/ Restriktiv kardiomyopati hos en familj birmakatter Ekman, Emma Veterinary science and hygiene - General aspects Cardiomyopathy is the most common type of cardiac disease in the cat. Restrictive cardiomyopathy (RCM) is comparably uncommon and only a few studies have been conducted in this disease. The purpose of this study was to examine the presence and inheritance pattern of RCM in a family of Birman cats. The family comprised 177 known cats. 107 of these cats were examined by echocardiography, 23 of the cats died/were euthanized and a diagnosis could be established post mortem. Out of the examined cats, 18 were diagnosed with RCM, 4 of them with strong suspicion of RCM, 10 equivocals (borderline cases), 4 with HCM, and 2 with aortic stenosis. Remaining cats were classified as free from cardiac disease at the time of examination. The age of diseased cats were between 10 months and 9 years. No sex predilection could be observed. The study indicates that genetic factors contribute to disease development. The mode of inheritance could not be fully characterized, but a dominant mode of inheritance could most certainly be ruled out. The results suggest a recessive inheritance pattern, possibly with codominance or incomplete penetrance. In absence of a gene test, breeding should be avoided in diseased individuals and their siblings, offspring and parents. Breeding should be sparse in cases where RCM has not been confirmed but suspicious signs are present. Kardiomyopatier är den vanligaste typen av hjärtsjukdom hos katt. Restriktiv kardiomyopati (RCM) är relativt ovanlig och det finns endast ett fåtal studier om denna sjukdom. Målet med detta arbete var att undersöka förekomst av och nedärvningsmönster för RCM hos en familj birmakatter. Familjen omfattade 177 kända katter ur samma familj. Av dessa undersöktes 107 katter med ekokardiografi, 23 av katterna dog/avlivades och diagnos kunde ställas post mortem. Av de undersökta katterna fanns 18 stycken drabbade av RCM, 4 stycken med stark misstänkt RCM, 10 stycken equivocala (gränsfall), 4 stycken med HCM och 2 stycken med aortastenos. Övriga katter klassificerades som friska med avseende på hjärtsjukdomar vid undersökningstillfället. Ålder på drabbade katter låg mellan 10 månader och 9 år. Ingen könspredilektion kunde ses. Studien visade att ärftlighet föreligger. Nedärvningsmönstret kunde inte helt fastställas, men en dominant arvsgång kunde med största sannolikhet uteslutas. Utfallet tyder på att en recessiv arvsgång är mest trolig, eventuellt med codominans eller ofullständig penetrans. I frånvaro av ett gentest avråds tills vidare från avel på sjuka individer samt på deras syskon, avkommor och föräldrar. Avel bör ske med försiktighet hos de individer där diagnosen RCM ej säkert kunnat fastställas men där misstänkta fynd föreligger. 2009-07-10 Other NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/11815/1/ekman_e_171016.pdf Ekman, Emma, 2009. Restriktiv kardiomyopati hos en familj birmakatter. UNSPECIFIED, Uppsala. Uppsala: (VH) > Dept. of Clinical Sciences (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-715.html> urn:nbn:se:slu:epsilon-s-7872 swe |
| spellingShingle | Veterinary science and hygiene - General aspects Ekman, Emma Restriktiv kardiomyopati hos en familj birmakatter |
| title | Restriktiv kardiomyopati hos en familj birmakatter |
| title_full | Restriktiv kardiomyopati hos en familj birmakatter |
| title_fullStr | Restriktiv kardiomyopati hos en familj birmakatter |
| title_full_unstemmed | Restriktiv kardiomyopati hos en familj birmakatter |
| title_short | Restriktiv kardiomyopati hos en familj birmakatter |
| title_sort | restriktiv kardiomyopati hos en familj birmakatter |
| topic | Veterinary science and hygiene - General aspects |
| url | https://stud.epsilon.slu.se/11815/ https://stud.epsilon.slu.se/11815/ |