Utvärdering av autologt konditionerat serum
Joint injury (inflammation) or osteoarthritis is the most common cause of poor performance in the athletic horse. Osteoarthritis is the ensuing degeneration of joint cartilage due to inflammation/injury. The single most important factor in the inflammation cascade of joint injuries is interleukin-1...
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| Formato: | Otro |
| Lenguaje: | sueco sueco |
| Publicado: |
2009
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| Acceso en línea: | https://stud.epsilon.slu.se/11811/ |
| _version_ | 1855571944370339840 |
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| author | Österdahl, John |
| author_browse | Österdahl, John |
| author_facet | Österdahl, John |
| author_sort | Österdahl, John |
| collection | Epsilon Archive for Student Projects |
| description | Joint injury (inflammation) or osteoarthritis is the most common cause of poor performance in the athletic horse. Osteoarthritis is the ensuing degeneration of joint cartilage due to inflammation/injury. The single most important factor in the inflammation cascade of joint injuries is interleukin-1 (IL-1). Until recently, these injuries have been treated with products like hyaluronic acid, cortisone and polysulphated glycosaminoglycans (PSGAG).
Several studies have not been able to demonstrate a significant difference in the clinical improvement of joint injuries treated with hyaluronic acid or PSGAG and saline. Cortisone is a potent-inflammatory agent that may on the other hand delay injury repair and has a catabolic effect on joint cartilage.
Autologous conditioned serum (ACS, trade name; Irap) is a therapeutic method where the horse's own blood is used to create an anti-inflammatory "soup", containing mainly interleukin-1 receptor protein antagonists. The theoretic basis for the use of ACS in inflamed joints is sound, as well as the results of clinical trails where Irap have been tested against hyaluronic acid and saline.
In this clinical survey, Irap was compared with hyaluronic acid and PSGAG in two groups of ten intermediate level jumping horses at two equine clinics. The horses included in this survey were not responsive to treatment with hyaluronic acid or PSGAG and subsequently treated with Irap. A measure for successful treatment with Irap was the return to normal performance three month post treatment.
Seven of ten and ten of ten horses returned to full activity after three month post treatment with Irap that had not responded to hyaluronic acid or PSGAG.
This survey indicates that Irap is well worth further investigation as a therapeutic model of osteoarthritis/osteoarthrosis in the athletic horse. |
| format | Otro |
| id | RepoSLU11811 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish swe |
| publishDate | 2009 |
| publishDateSort | 2009 |
| record_format | eprints |
| spelling | RepoSLU118112017-10-17T06:13:18Z https://stud.epsilon.slu.se/11811/ Utvärdering av autologt konditionerat serum Österdahl, John Veterinary science and hygiene - General aspects Joint injury (inflammation) or osteoarthritis is the most common cause of poor performance in the athletic horse. Osteoarthritis is the ensuing degeneration of joint cartilage due to inflammation/injury. The single most important factor in the inflammation cascade of joint injuries is interleukin-1 (IL-1). Until recently, these injuries have been treated with products like hyaluronic acid, cortisone and polysulphated glycosaminoglycans (PSGAG). Several studies have not been able to demonstrate a significant difference in the clinical improvement of joint injuries treated with hyaluronic acid or PSGAG and saline. Cortisone is a potent-inflammatory agent that may on the other hand delay injury repair and has a catabolic effect on joint cartilage. Autologous conditioned serum (ACS, trade name; Irap) is a therapeutic method where the horse's own blood is used to create an anti-inflammatory "soup", containing mainly interleukin-1 receptor protein antagonists. The theoretic basis for the use of ACS in inflamed joints is sound, as well as the results of clinical trails where Irap have been tested against hyaluronic acid and saline. In this clinical survey, Irap was compared with hyaluronic acid and PSGAG in two groups of ten intermediate level jumping horses at two equine clinics. The horses included in this survey were not responsive to treatment with hyaluronic acid or PSGAG and subsequently treated with Irap. A measure for successful treatment with Irap was the return to normal performance three month post treatment. Seven of ten and ten of ten horses returned to full activity after three month post treatment with Irap that had not responded to hyaluronic acid or PSGAG. This survey indicates that Irap is well worth further investigation as a therapeutic model of osteoarthritis/osteoarthrosis in the athletic horse. Största anledningen till prestationsnedsättning hos sporthästar idag är osteoartrit. Artritens förlängning, osteoartros, karaktäriseras av nedbrytning av ledbrosket. Interleukin-1 (IL-1) anses vara den enskilt viktigaste faktorn i inflammationskaskaden som leder till ledbroskdegeneration. Dessa skador har fram tills idag i princip behandlats med produkter som kortison, hyaluronsyra och polysulfaterad glykosaminoglykaner (PSGAG). Vid ledbehandling så har inga signifikanta skillnader i effekt kunnat påvisas mellan PSGAG, hyaluronsyra och koksalt. Kortison har däremot i vissa fall kunnat fördröja läkeprocessen samt ha en katabol effekt på ledbrosket. Autologt konditionerat serum (ACS, handelsnamn häst; Irap) är en autolog behandlingsmetod där hästens eget blod inkuberas och cetrifugeras för att skapa en immunologisk ”soppa” bestående främst av interleukin-1 receptor protein antagonister. Det teoretiska stödet är starkt samt även de kliniska utfallen i flera studier där metoden har jämförts mot hyaluronsyra och koksalt. I den här uppsatsen jämfördes behandlingsutfallet av Irap på hopphästar, med en ålder av 6-14 år på en nivå från medelsvår och uppåt och som ej blivit bra efter tidigare behandling av artrit/artros med PSGAG eller hyaluronsyra, vid två veterinärpraktiker i mälardalen. Som mått på lyckad behandling var återgång till sport efter tre månader. Behandlingsresultaten vid de båda veterinärpraktikerna var att 70 % respektive 100 % av behandlade hästar återgick till sport. Studiens resultat indikerar att det kan vara värt att vidare studera Irap som behandlingsmodell för osteoartrit/osteoartros. 2009-05-27 Other NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/11811/1/osterdahl_j_171017.pdf Österdahl, John, 2008. Utvärdering av autologt konditionerat serum. UNSPECIFIED, Uppsala. Uppsala: (VH) > Dept. of Clinical Sciences (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-715.html> urn:nbn:se:slu:epsilon-s-7878 swe |
| spellingShingle | Veterinary science and hygiene - General aspects Österdahl, John Utvärdering av autologt konditionerat serum |
| title | Utvärdering av autologt konditionerat serum |
| title_full | Utvärdering av autologt konditionerat serum |
| title_fullStr | Utvärdering av autologt konditionerat serum |
| title_full_unstemmed | Utvärdering av autologt konditionerat serum |
| title_short | Utvärdering av autologt konditionerat serum |
| title_sort | utvärdering av autologt konditionerat serum |
| topic | Veterinary science and hygiene - General aspects |
| url | https://stud.epsilon.slu.se/11811/ https://stud.epsilon.slu.se/11811/ |