Njurfunktion hos hypertyreoida katter
Hyperthyroidism and chronic kidney failure (CKD) are common diseases in older cats. It can be difficult to evaluate kidney function in cats suffering from both conditions simultaneously. In the daily clinic serum creatinine is the analysis of choice when evaluating kidney function and secondary glom...
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| Formato: | Otro |
| Lenguaje: | sueco sueco |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://stud.epsilon.slu.se/11774/ |
| _version_ | 1855571936479805440 |
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| author | Sixtensdotter Sandberg, Helena |
| author_browse | Sixtensdotter Sandberg, Helena |
| author_facet | Sixtensdotter Sandberg, Helena |
| author_sort | Sixtensdotter Sandberg, Helena |
| collection | Epsilon Archive for Student Projects |
| description | Hyperthyroidism and chronic kidney failure (CKD) are common diseases in older cats. It can be difficult to evaluate kidney function in cats suffering from both conditions simultaneously. In the daily clinic serum creatinine is the analysis of choice when evaluating kidney function and secondary glomerular filtration rate (GFR). This marker does not, however, detect kidney damage until about 75 % of the function is lost. There are several other techniques available when investigating GFR but none are readily available for the small clinic. It would be of great interest if there was a marker that could be analyzed from a simple blood sample and that illustrates GFR better than serum creatinine.
Since several years there is such a marker available in human medicine, serum cystatin C (CysC) that has been claimed to be superior to serum creatinine. The present study was performed to evaluate kidney function in hyperthyroid cats and whether CysC is useful in cats also. Samples from 32 consecutive cats (8 euthyroid and 24 hyperthyroid) were selected and analyzed for serum creatinine and CysC. The hyperthyroid cats had all been treated with either methimazole or radioactive iodine. The results of this study indicate a correlation between serum creatinine and CysC in cats. The euthyroid cats had generally lower serum levels of both creatinine and cystatin C than cats in the hyperthyroid group. Noticeably cats in both groups seemed to have higher levels of CysC than humans.
Further studies are required before CysC can be an alternative to serum creatinine in daily practice considering kidney function in cats. There is also a need for establishing reference values in cats. |
| format | Otro |
| id | RepoSLU11774 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish swe |
| publishDate | 2008 |
| publishDateSort | 2008 |
| record_format | eprints |
| spelling | RepoSLU117742017-10-17T10:51:24Z https://stud.epsilon.slu.se/11774/ Njurfunktion hos hypertyreoida katter Sixtensdotter Sandberg, Helena Veterinary science and hygiene - General aspects Hyperthyroidism and chronic kidney failure (CKD) are common diseases in older cats. It can be difficult to evaluate kidney function in cats suffering from both conditions simultaneously. In the daily clinic serum creatinine is the analysis of choice when evaluating kidney function and secondary glomerular filtration rate (GFR). This marker does not, however, detect kidney damage until about 75 % of the function is lost. There are several other techniques available when investigating GFR but none are readily available for the small clinic. It would be of great interest if there was a marker that could be analyzed from a simple blood sample and that illustrates GFR better than serum creatinine. Since several years there is such a marker available in human medicine, serum cystatin C (CysC) that has been claimed to be superior to serum creatinine. The present study was performed to evaluate kidney function in hyperthyroid cats and whether CysC is useful in cats also. Samples from 32 consecutive cats (8 euthyroid and 24 hyperthyroid) were selected and analyzed for serum creatinine and CysC. The hyperthyroid cats had all been treated with either methimazole or radioactive iodine. The results of this study indicate a correlation between serum creatinine and CysC in cats. The euthyroid cats had generally lower serum levels of both creatinine and cystatin C than cats in the hyperthyroid group. Noticeably cats in both groups seemed to have higher levels of CysC than humans. Further studies are required before CysC can be an alternative to serum creatinine in daily practice considering kidney function in cats. There is also a need for establishing reference values in cats. Hypertyreoidism och kronisk njursjukdom är de två vanligaste sjukdomarna hos äldre katter. Det kan vara svårt att utvärdera njurfunktionen hos katter med båda sjukdomarna parallellt. I dagsläget har den mindre kliniken begränsade resurser för att utvärdera njurfunktionen hos hypertyreoida katter. Det är framförallt Skreatinin som har använts för att spegla den glomerulära filtrationshastigheten men det är ett trubbigt instrument som visar på njurdysfunktion först då en stor del av funktionen redan är förlorad. Hos människa används sedan flera år S-cystatin C i rutindiagnostiken för att värdera njurfunktionen vid bl. a. hypertyreos. I det här försöket har TT4, S-kreatinin och -cystatin C analyserats hos två grupper av katter. Den ena gruppen bestod av åtta friska katter och den andra gruppen av 24 hypertyreoida katter som hade behandlats med antingen radiojod eller metamizol. Katterna i studien låg generellt högre avseende S-cystatin C jämfört med människa då friska katter (n=8) hade ett medelvärde på 1,6±0,4 mg/l och hypertyreoida som behandlats (n=24) hade 2,3±0,7 mg/ml. 2008-06-19 Other NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/11774/1/sandberg_h_171017.pdf Sixtensdotter Sandberg, Helena, 2008. Njurfunktion hos hypertyreoida katter : en jämförelse mellan serumkreatinin och serumcystatin C. UNSPECIFIED, Uppsala. Uppsala: (VH) > Dept. of Clinical Sciences (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-715.html> urn:nbn:se:slu:epsilon-s-7915 swe |
| spellingShingle | Veterinary science and hygiene - General aspects Sixtensdotter Sandberg, Helena Njurfunktion hos hypertyreoida katter |
| title | Njurfunktion hos hypertyreoida katter |
| title_full | Njurfunktion hos hypertyreoida katter |
| title_fullStr | Njurfunktion hos hypertyreoida katter |
| title_full_unstemmed | Njurfunktion hos hypertyreoida katter |
| title_short | Njurfunktion hos hypertyreoida katter |
| title_sort | njurfunktion hos hypertyreoida katter |
| topic | Veterinary science and hygiene - General aspects |
| url | https://stud.epsilon.slu.se/11774/ https://stud.epsilon.slu.se/11774/ |