Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund
Primary ciliary dyskinesia (PCD) is an important but unusual cause of chronic respiratory disease of young dogs. The purpuse of this paper is to study and present internationally publicated papers on PCD in dogs and present three dogs, in which PCD was suspected. PCD has been reported in many do...
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| Format: | Otro |
| Language: | Swedish Swedish |
| Published: |
2008
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| Online Access: | https://stud.epsilon.slu.se/11754/ |
| _version_ | 1855571932034891776 |
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| author | Andersson, Linda |
| author_browse | Andersson, Linda |
| author_facet | Andersson, Linda |
| author_sort | Andersson, Linda |
| collection | Epsilon Archive for Student Projects |
| description | Primary ciliary dyskinesia (PCD) is an important but unusual cause of chronic respiratory disease of young dogs. The purpuse of this paper is to study and present internationally publicated papers on PCD in dogs and present three dogs, in which PCD was suspected.
PCD has been reported in many dog breeds as well as in people. In dogs an humans, PCD is caused by inborn genetical defects which causes structural and functional abnormalities of cilia in the respiratory organs and other cilia in the body. Situs inversus occurs in about half the cases in people and probably in dogs as well. Respiratory signs usually predominate. Because of dysfunctional cilia in the respiratory organs, the mucociliary clearance is impaired. The airways become congested with mucus that predisposes the dogs to bacterial infections and irreversible changes lika bronchiectasis. Dogs are often young when first presented with respiratory signs and with infections that are resistent to treatment. Definitive diagnosis in dogs can be established only by demonstrating presence of specific ultrastructural leisions in cilia with transmission electronmicroscope (TEM) and by demonstrating impaired mucociliary clearance in the airways with a gammacamera. Which test that could be performed, should be based on the case in question. Sometimes the diagnosis can not be esteblished. Treatement for PCD is aimed at fascilitating mucociliary clearance and controlling infections. The prognosis is guardead in dogs but better the earlier diagnosis is established. Long term consequenses include irreversible changes in the respiratory organs as well as right-sided heart failure caused by pulmonary artery hypertension. PCD can be prevented by breedingprograms, once dogs with PCD have been identified.
In this paper, three dogs are presented, in which PCD was suspected. The three cases were rottweilers and from the same litter. They lived in separate homes and were between four and 16 mounths when first presented. They all had upper and lower respiratory signs, radiographs of the thorax that revealed bronchopneumonia and poor responses to treatment with antibiotics and prednisolone. The dogs were euthanased and biopsis were taken from their tracheas and were examined with TEM. No abnormal ciliary ultrastructure was found and the diagnosis PCD could not be confirmed or dismissed.
The conclusion is that PCD should be considered in young dogs with chronic recurring repsiratory signs. Which tests and in what order they are performed for a definitive diagnosis, should be based on the case in question. |
| format | Otro |
| id | RepoSLU11754 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish swe |
| publishDate | 2008 |
| publishDateSort | 2008 |
| record_format | eprints |
| spelling | RepoSLU117542017-10-17T11:55:47Z https://stud.epsilon.slu.se/11754/ Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund Andersson, Linda Animal diseases Primary ciliary dyskinesia (PCD) is an important but unusual cause of chronic respiratory disease of young dogs. The purpuse of this paper is to study and present internationally publicated papers on PCD in dogs and present three dogs, in which PCD was suspected. PCD has been reported in many dog breeds as well as in people. In dogs an humans, PCD is caused by inborn genetical defects which causes structural and functional abnormalities of cilia in the respiratory organs and other cilia in the body. Situs inversus occurs in about half the cases in people and probably in dogs as well. Respiratory signs usually predominate. Because of dysfunctional cilia in the respiratory organs, the mucociliary clearance is impaired. The airways become congested with mucus that predisposes the dogs to bacterial infections and irreversible changes lika bronchiectasis. Dogs are often young when first presented with respiratory signs and with infections that are resistent to treatment. Definitive diagnosis in dogs can be established only by demonstrating presence of specific ultrastructural leisions in cilia with transmission electronmicroscope (TEM) and by demonstrating impaired mucociliary clearance in the airways with a gammacamera. Which test that could be performed, should be based on the case in question. Sometimes the diagnosis can not be esteblished. Treatement for PCD is aimed at fascilitating mucociliary clearance and controlling infections. The prognosis is guardead in dogs but better the earlier diagnosis is established. Long term consequenses include irreversible changes in the respiratory organs as well as right-sided heart failure caused by pulmonary artery hypertension. PCD can be prevented by breedingprograms, once dogs with PCD have been identified. In this paper, three dogs are presented, in which PCD was suspected. The three cases were rottweilers and from the same litter. They lived in separate homes and were between four and 16 mounths when first presented. They all had upper and lower respiratory signs, radiographs of the thorax that revealed bronchopneumonia and poor responses to treatment with antibiotics and prednisolone. The dogs were euthanased and biopsis were taken from their tracheas and were examined with TEM. No abnormal ciliary ultrastructure was found and the diagnosis PCD could not be confirmed or dismissed. The conclusion is that PCD should be considered in young dogs with chronic recurring repsiratory signs. Which tests and in what order they are performed for a definitive diagnosis, should be based on the case in question. Primär ciliär dyskinesi (PCD) är en viktig men ovanlig orsak till kroniska luftvägsproblem hos unga hundar och beskrivs endast kortfattat i litteraturen. Syftet med arbetet är att studera och presentera internationellt publicerade artiklar om PCD hos hund, samt presentera tre misstänkta fall av PCD hos hund. PCD finns beskriven hos många hundraser liksom hos människa. PCD orsakas hos hund och människa av medfödda genetiska defekter, vilka medför dyskinetiska cilier i respirationsorganen och i övriga cilierade organ. Hos de flesta fall av PCD hos hund, kan ultrastrukturella avvikelser påvisas i cilierna. I hälften av fallen, förekommer hos människa och troligen hos hund, samtidig situs inversus. Symptomen från respirationsorganen dominerar i regel. Till följd av dyskinetiska cilier i respirationsorganen, blir slemtransporten nedsatt. Slem ansamlas då och predisponerar för bakteriella infektioner och irreversibla förändringar som bronkiektasi. Hundar är ofta unga vid symptomdebut och uppvisar behandlingsresistenta övre och nedre luftvägsinfektioner. För definitiv diagnos krävs påvisande av strukturella avvikelser i cilierna, vilket kan göras med transmissionselektronmikroskop (TEM) och funktionella avvikelser, vilket kan studeras indirekt genom mätning av slemtransporten i luftvägarna med en gammakamera och radioaktiv substans. Det aktuella fallets karaktär och tillgänglig metodik avgör vilka tester och i vilken ordning de bör utföras. I vissa fall kan diagnosen ej ställas. Behandlingen av fall hos hund är symptomatisk och koncentreras på att underlätta slemtransport och förhindra infektioner. Prognosen är avvaktande hos hund men bättre ju tidigare diagnosen ställs. Långtidskonsekvenser av PCD inkluderar irreversibla förändringar i respirationsorganen liksom utveckling av högersidig hjärtsvikt till följd av hypertension i lungornas kärlbädd. PCD kan förebyggas genom att undvika avel på drabbade individer. Tre misstänkta fall av PCD hos hund beskrivs i arbetet. De tre hundarna var kullsyskon av rasen rottweiler och ingick i en kull om totalt sju hundar. De kom från olika hem och var mellan fyra och 16 månader gamla vid första presentationen. De hade alla tre symtom på övre och nedre luftvägsinfektioner, röntgenförändringar som tolkades som bronkopneumoni och undermålig behandlingsframgång med antibiotika och prednisolon. Vävnadsprov togs från trakea från alla tre hundar i samband med avlivning och undersöktes i transmissionselektronmikroskop (TEM). Ingen avvikande ciliär ultrastruktur påvisades och diagnosen PCD kunde därför varken ställas eller avfärdas. Konklusionen är att PCD bör misstänkas på unga hundar med återkommande behandlingsresistenta luftvägsinfektioner. Hur en hund utreds bör grundas på det aktuella fallets karaktär, vilket även bör ligga till grund för i vilket ordning testerna utförs. 2008-01-28 Other NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/11754/1/andersson_l_171017.pdf Andersson, Linda, 2008. Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund : en litteraturstudie och fallpresentation. UNSPECIFIED, Uppsala. Uppsala: (VH) > Dept. of Clinical Sciences (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-715.html> urn:nbn:se:slu:epsilon-s-7935 swe |
| spellingShingle | Animal diseases Andersson, Linda Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title | Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title_full | Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title_fullStr | Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title_full_unstemmed | Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title_short | Primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| title_sort | primär ciliär dyskinesi som orsak till kronisk lungsjukdom hos hund |
| topic | Animal diseases |
| url | https://stud.epsilon.slu.se/11754/ https://stud.epsilon.slu.se/11754/ |