Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund
Mammary tumors are the most frequent type of tumors in bitches in Sweden. Many studies have been published concerning mammary tumors, but there is still much to be learned about this disease. One has, since some time ago, had the knowledge that addition to or removal of methyl groups to genes...
| Autor principal: | |
|---|---|
| Formato: | L3 |
| Lenguaje: | sueco Inglés |
| Publicado: |
SLU/Dept. of Animal Environment and Health (until 231231)
2006
|
| Materias: |
| _version_ | 1855571826990645248 |
|---|---|
| author | Norell, Maria |
| author_browse | Norell, Maria |
| author_facet | Norell, Maria |
| author_sort | Norell, Maria |
| collection | Epsilon Archive for Student Projects |
| description | Mammary tumors are the most frequent type of tumors in bitches in Sweden. Many
studies have been published concerning mammary tumors, but there is still much to
be learned about this disease.
One has, since some time ago, had the knowledge that addition to or removal of
methyl groups to genes can inhibit or activate gene-expression. Methylation and
demethylation is a normal phenomenon in the body and it is essential for the
development and survival of the individual. The risk of developing a tumor disease is
increased if the global methylationstatus is changed; if oncogenes demethylates
(activates) or if tumor suppressor genes methylates (inactivates). In the human
medicine one has seen that there are differences in methylationstatus between
different tumors.
In this study tumor and normal tissue from ten dogs were examined with regard to
methylationstatus. The results showed that there were not clear connections between
the methylationstatus at the normal- or tumor tissue respectively, sometimes the
normal tissue was hypermethylated in comparison to the tumor tissue and sometimes
it was hypomethylated in comparison. The connection that one could see was that the
malignant tumors tended to be hypermethylated in comparison to the benign tumors. |
| format | L3 |
| id | RepoSLU11198 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2006 |
| publishDateSort | 2006 |
| publisher | SLU/Dept. of Animal Environment and Health (until 231231) |
| publisherStr | SLU/Dept. of Animal Environment and Health (until 231231) |
| record_format | eprints |
| spelling | RepoSLU111982017-09-26T08:36:55Z Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund Norell, Maria epigenetik juvertumörer hund metyleringsstatus metylering acetylering Mammary tumors are the most frequent type of tumors in bitches in Sweden. Many studies have been published concerning mammary tumors, but there is still much to be learned about this disease. One has, since some time ago, had the knowledge that addition to or removal of methyl groups to genes can inhibit or activate gene-expression. Methylation and demethylation is a normal phenomenon in the body and it is essential for the development and survival of the individual. The risk of developing a tumor disease is increased if the global methylationstatus is changed; if oncogenes demethylates (activates) or if tumor suppressor genes methylates (inactivates). In the human medicine one has seen that there are differences in methylationstatus between different tumors. In this study tumor and normal tissue from ten dogs were examined with regard to methylationstatus. The results showed that there were not clear connections between the methylationstatus at the normal- or tumor tissue respectively, sometimes the normal tissue was hypermethylated in comparison to the tumor tissue and sometimes it was hypomethylated in comparison. The connection that one could see was that the malignant tumors tended to be hypermethylated in comparison to the benign tumors. Juvertumörer är den vanligaste tumörformen hos tikar. Trots att det har utförts många studier om juvertumörer finns ännu en hel del kvar att lära om denna tumörtyp. Man har sedan en längre tid tillbaka haft kunskapen om att adderandet respektive eliminerandet av metylgrupper till gener kan hämma respektive aktivera dessa geners uttryck. Metylering och demetylering är en i kroppen helt normalt förekommande företeelse och den är essentiell för individens utveckling och fortlevnad. Risken för att utveckla en tumörsjukdom ökar dock om den globala metyleringsstatusen i kroppen ändras; om onkogener demetyleras (aktiveras) eller om tumörsupressorgener metyleras (inaktiveras). Inom humanmedicinen har man sett att det finns skillnader i metyleringsstatus mellan olika tumörer. I denna studie undersöktes tumör- och normalvävnad från tio olika hundar med avseende på metyleringsstatus. Resultaten visade att det inte fanns något klart samband mellan metyleringsstatus hos normal respektive tumörvävnad, ibland var normalvävnaden hypermetylerad jämfört med tumörvävnaden och ibland var den hypometylerad i jämförelse. Det samband man däremot kunde urskilja, var att de maligna juvertumörerna tenderade att vara hypermetylerade i jämförelse med de benigna SLU/Dept. of Animal Environment and Health (until 231231) 2006 L3 swe eng https://stud.epsilon.slu.se/11198/ |
| spellingShingle | epigenetik juvertumörer hund metyleringsstatus metylering acetylering Norell, Maria Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title | Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title_full | Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title_fullStr | Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title_full_unstemmed | Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title_short | Undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| title_sort | undersökning av global epigenetisk metyleringsstatus hos juvertumörer på hund |
| topic | epigenetik juvertumörer hund metyleringsstatus metylering acetylering |