Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark
The lions at Kolmårdens zoo are vaccinated against Feline Panleukopenivirus (FPV). In 1994 there was an outbreak among the lions at the zoo of FPV disease. A retrospective study has been made to measure the antibodytiters in vaccinated lions and lions that lived during the outbreak. An ImmunoPero...
| Main Author: | |
|---|---|
| Format: | L3 |
| Language: | Swedish Inglés |
| Published: |
SLU/Dept. of Molecular Biosciences
2006
|
| Subjects: |
| _version_ | 1855571825976672256 |
|---|---|
| author | Ohlson, Karin |
| author_browse | Ohlson, Karin |
| author_facet | Ohlson, Karin |
| author_sort | Ohlson, Karin |
| collection | Epsilon Archive for Student Projects |
| description | The lions at Kolmårdens zoo are vaccinated against Feline Panleukopenivirus
(FPV). In 1994 there was an outbreak among the lions at the zoo of FPV disease.
A retrospective study has been made to measure the antibodytiters in vaccinated
lions and lions that lived during the outbreak. An ImmunoPeroxidase Monolayer
Assay (IPMA) was used to analyze the titers in the sera from the lions.
Lions were divided into five groups. Group 1, 2 and 3 contained lions vaccinated
one, two and three times respectively (a total of 40 animals). The lions of Group 4
were born in 2004 (six lioncubs) and were vaccinated according to different
regimes and the changes in antibodytiters were followed as respose to vaccination
during the spring 2005. Group 5 consisted of twelve lions that were alive during
disease outbreak 1994. The antibody response post vaccination was dependent on
the age of the lion at time of vaccination. Lions younger than 23 w. when
vaccinated mounted a lower antibody response than the ones that were older than
23 w.
Lions that had been naturally infected had high titers, which still were high eight
years after the outbreak. Lions tested as long as four years post vaccination still
showed antibody titers towards FPV. |
| format | L3 |
| id | RepoSLU11193 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2006 |
| publishDateSort | 2006 |
| publisher | SLU/Dept. of Molecular Biosciences |
| publisherStr | SLU/Dept. of Molecular Biosciences |
| record_format | eprints |
| spelling | RepoSLU111932017-09-26T08:50:12Z Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark Ohlson, Karin kattpest antikroppar Kolmården lejon The lions at Kolmårdens zoo are vaccinated against Feline Panleukopenivirus (FPV). In 1994 there was an outbreak among the lions at the zoo of FPV disease. A retrospective study has been made to measure the antibodytiters in vaccinated lions and lions that lived during the outbreak. An ImmunoPeroxidase Monolayer Assay (IPMA) was used to analyze the titers in the sera from the lions. Lions were divided into five groups. Group 1, 2 and 3 contained lions vaccinated one, two and three times respectively (a total of 40 animals). The lions of Group 4 were born in 2004 (six lioncubs) and were vaccinated according to different regimes and the changes in antibodytiters were followed as respose to vaccination during the spring 2005. Group 5 consisted of twelve lions that were alive during disease outbreak 1994. The antibody response post vaccination was dependent on the age of the lion at time of vaccination. Lions younger than 23 w. when vaccinated mounted a lower antibody response than the ones that were older than 23 w. Lions that had been naturally infected had high titers, which still were high eight years after the outbreak. Lions tested as long as four years post vaccination still showed antibody titers towards FPV. Lejonen i Kolmårdens Djurpark insjuknade 1994 i en infektionssjukdom som kunde diagnosticeras som kattpest. Sedan slutet av 1990-talet vaccineras parkens lejon mot sjukdomen med vaccinet Nobivac Tricat från Intervet. En studie på serumprover från lejonen har utförts. Proverna var tagna 1988-2005. Sera analyserades med avseende på antikroppar mot Felint Panleukopenivirus med en ImmunoPeroxidase Monolayer Assay (IPMA). Lejonen delades in i grupper enligt följande: I Grupp 1, 2 och 3 placerades 40 lejon som vaccinerats mot kattpest en, två respektive tre gånger. Grupp 4 bestod av två kullar lejonungar (sex individer) som vaccinerades på två olika sätt under våren 2005 för att se hur och om antikroppssvaret varierade mellan de olika vaccinationssätten. Grupp 5 bestod av tolv lejon som levde under kattpestutbrottet 1994. Lejonen hade utvecklat varierande antikroppstitrar. De lejon som levde under kattpestutbrottet hade mycket högre titrar än de djur som var vaccinerade. Antikroppstitrarna efter infektion låg hos några individer kvar i minst åtta år efter infektionen. De lejon som vaccinerats vid en ålder av 23 v. eller mer visade högre antikroppstiter än lejon vaccinerade vid tidigare ålder. Maternella antikroppar hos unga djur kan vara en orsak till sämre antikroppssvar hos yngre djur. En dos kattvaccin verkar vara tillräckligt för att merparten av lejonen ska få en antikroppstiter på 1/90 eller högre. För att man ska få en god effekt av vaccineringen föreslås att lejonen vaccineras vid en ålder av minst 23 v. Några individer har visat positiv antikroppstiter efter vaccination fyra år efter vaccinationen. SLU/Dept. of Molecular Biosciences 2006 L3 swe eng https://stud.epsilon.slu.se/11193/ |
| spellingShingle | kattpest antikroppar Kolmården lejon Ohlson, Karin Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title | Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title_full | Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title_fullStr | Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title_full_unstemmed | Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title_short | Antikroppsstatus mot kattpest hos lejonen i Kolmårdens Djurpark |
| title_sort | antikroppsstatus mot kattpest hos lejonen i kolmårdens djurpark |
| topic | kattpest antikroppar Kolmården lejon |