Dermoid sinus hos Rhodesian ridgeback
Rhodesian ridgeback is a dog breed that originates from southern Africa. The characteristic ridge (a dorsal ridge where the hair grows in the opposite direction to the general coat) is shared with an Asian breed, Thai ridgeback. The origin and inheritance of the ridge has been examined and defined....
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| Formato: | L3 |
| Lenguaje: | sueco Inglés |
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SLU/Dept. of Animal Breeding and Genetics (until 231231)
2008
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| Materias: |
| _version_ | 1855571818482499584 |
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| author | Bergman, Ingrid |
| author_browse | Bergman, Ingrid |
| author_facet | Bergman, Ingrid |
| author_sort | Bergman, Ingrid |
| collection | Epsilon Archive for Student Projects |
| description | Rhodesian ridgeback is a dog breed that originates from southern Africa. The characteristic ridge (a dorsal ridge where the hair grows in the opposite direction to the general coat) is shared with an Asian breed, Thai ridgeback. The origin and inheritance of the ridge has been examined and defined. The ridge-mutation is a duplication that contains four complete genes, FGF3, FGF4, FGF19 and ORAOV1 and the 3´-end of CCND1. The ridge is inherited as an autosomal, dominant trait and predisposes for Dermoid sinus (DS), a disease that develops during embryogenesis. The aim with this thesis is to look into the possibilities to reduce the number of dogs that gets affected by DS. DS belongs to a group of congenital malformations that is called Neural Tube Defects (NTD) and also can affect humans. Studies on humans have shown that addition of folic acid during pregnancy can reduce the risk of being affected by these malformations. According to an Australian study the same seems to apply to Rhodesian ridgebacks. Another suggestion to reduce the occurrence of DS in Rhodesian ridgebacks is to use ridgeless dogs in breeding. Dogs with ridge, which are homozygous for the mutation, are predisposed to DS, while ridgeless dogs never get affected by DS. By using a ridgeless dog there would not be any offspring homozygous for the mutation. Yet another suggestion is that a DNA-test should be developed to show the genotype of breeding dogs and exclude those with multiple copies of the duplication which may be at larger risk of producing offspring with DS. |
| format | L3 |
| id | RepoSLU11159 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2008 |
| publishDateSort | 2008 |
| publisher | SLU/Dept. of Animal Breeding and Genetics (until 231231) |
| publisherStr | SLU/Dept. of Animal Breeding and Genetics (until 231231) |
| record_format | eprints |
| spelling | RepoSLU111592017-09-27T08:01:02Z Dermoid sinus hos Rhodesian ridgeback Dermoid sinus in the Rhodesian ridgeback Bergman, Ingrid Rhodesian ridgeback dermoid sinus folsyra Rhodesian ridgeback is a dog breed that originates from southern Africa. The characteristic ridge (a dorsal ridge where the hair grows in the opposite direction to the general coat) is shared with an Asian breed, Thai ridgeback. The origin and inheritance of the ridge has been examined and defined. The ridge-mutation is a duplication that contains four complete genes, FGF3, FGF4, FGF19 and ORAOV1 and the 3´-end of CCND1. The ridge is inherited as an autosomal, dominant trait and predisposes for Dermoid sinus (DS), a disease that develops during embryogenesis. The aim with this thesis is to look into the possibilities to reduce the number of dogs that gets affected by DS. DS belongs to a group of congenital malformations that is called Neural Tube Defects (NTD) and also can affect humans. Studies on humans have shown that addition of folic acid during pregnancy can reduce the risk of being affected by these malformations. According to an Australian study the same seems to apply to Rhodesian ridgebacks. Another suggestion to reduce the occurrence of DS in Rhodesian ridgebacks is to use ridgeless dogs in breeding. Dogs with ridge, which are homozygous for the mutation, are predisposed to DS, while ridgeless dogs never get affected by DS. By using a ridgeless dog there would not be any offspring homozygous for the mutation. Yet another suggestion is that a DNA-test should be developed to show the genotype of breeding dogs and exclude those with multiple copies of the duplication which may be at larger risk of producing offspring with DS. Rhodesian ridgeback är en hundras som stammar från södra Afrika. Den karaktäristiska ridgen (en hårkam längs ryggen där håren växer åt motsatt håll jämfört med resten av pälsen) delas med en annan ras, Thai ridgeback. Ursprunget och nedärvningen av ridgen har undersökts och utretts i flera studier. Ridgemutationen är en duplikation som innehåller fyra kompletta gener, FGF3, FGF4, FGF19 och ORAOV1 och 3´-delen av CCND1 genen. Det har även blivit klart att ridgen som nedärvs autosomalt dominant också predisponerar för Dermoid sinus (DS), en sjukdom som uppstår under embryonalutvecklingen. Syftet med litteraturstudien är att undersöka möjligheterna att minska antalet hundar som drabbas av DS. DS tillhör en grupp sjukdomar som kallas ”Neural Tube Defects” (NTD) som även förekommer hos människor. Studier på människor har visat att tillskott av folsyra under graviditeten kan minska risken att drabbas av dessa missbildningar. Detsamma verkar gälla för Rhodesian ridgebacks enligt en australiensisk studie. Ett annat förslag för att minska förekomsten av DS hos Rhodesian ridgebacks är att använda ridgelösa hundar i avel. Hundar med ridge, homozygota1 för mutationen, löper högre risk att drabbas av DS, medan ridgelösa hundar inte alls drabbas av DS. Genom att använda en ridgelös hund skulle inga avkommor homozygota för mutationen uppstå. Ännu ett förslag är att utveckla ett DNA-test för att visa genotypen 2 på hundar som ska användas i avel och utesluta dem med flera kopior av mutationen eftersom de sannolikt har högre risk att ge upphov till avkomma med DS. SLU/Dept. of Animal Breeding and Genetics (until 231231) 2008 L3 swe eng https://stud.epsilon.slu.se/11159/ |
| spellingShingle | Rhodesian ridgeback dermoid sinus folsyra Bergman, Ingrid Dermoid sinus hos Rhodesian ridgeback |
| title | Dermoid sinus hos Rhodesian ridgeback |
| title_full | Dermoid sinus hos Rhodesian ridgeback |
| title_fullStr | Dermoid sinus hos Rhodesian ridgeback |
| title_full_unstemmed | Dermoid sinus hos Rhodesian ridgeback |
| title_short | Dermoid sinus hos Rhodesian ridgeback |
| title_sort | dermoid sinus hos rhodesian ridgeback |
| topic | Rhodesian ridgeback dermoid sinus folsyra |