Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp
It is well known that dogs often have Helicobacter spp in their stomach. The importance of these bacteria in the development of gastrointestinal disease in dogs is still unknown. In humans, Helicobacter pylori is a causative agent of chronic gastritis and gastric ulcers. In contrast to humans, dogs...
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| Formato: | L3 |
| Lenguaje: | sueco Inglés |
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SLU/Dept. of Animal Environment and Health (until 231231)
2007
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| Materias: |
| _version_ | 1855571811721281536 |
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| author | Lindell, Elin |
| author_browse | Lindell, Elin |
| author_facet | Lindell, Elin |
| author_sort | Lindell, Elin |
| collection | Epsilon Archive for Student Projects |
| description | It is well known that dogs often have Helicobacter spp in their stomach. The importance of these bacteria in the development of gastrointestinal disease in dogs is still unknown. In humans, Helicobacter pylori is a causative agent of chronic gastritis and gastric ulcers. In contrast to humans, dogs seldom harbour naturally acquired H. pylori. Instead they are more often colonized by other Helicobacter spp, like Helicobacter bizzozeroni, Helicobacter salomonis and Helicobacter felis. Usually different species are present simultaneously, which makes it difficult to know if some species are responsible for the symptoms or if all species are normal inhabitants of the stomach. The widespread occurrence of Helicobacter spp in dogs also makes it difficult to find bacteria-free control groups. Despite the uncertainty about the role of Helicobacter spp in the pathogenesis of gastritis, there are treatment recommendations in the literature, often combinations of antibiotics and antacids.
This investigation is part of a larger study, with the aim to identify Helicobacter spp in stomach, saliva and faeces in healthy dogs and in dogs with signs of gastrointestinal disease. In addition, the histopathological appearance of the stomach was investigated, and correlated to presence of Helicobacter spp.
The occurrence of Helicobacter spp in the stomach and the histopathological appearance of the mucosa were investigated in 7 family dogs with signs of gastrointestinal disease and in 5 healthy colony dogs without signs of gastrointestinal disease. The presence of Helicobacter spp in saliva and faeces was investigated in the two groups and in 17 healthy family dogs without signs of gastrointestinal disease. Helicobacter-bacteria were identified with polymerase chain reaction (PCR) and light microscopy of histological sections.
The results show that Helicobacter spp are common in saliva, faeces and gastric mucosa in both healthy dogs and in dogs with signs of gastrointestinal disease. In general, the healthy colony dogs showed higher degree of abnormal histopathological findings than did the dogs with signs of gastrointestinal disease. Helicobacter spp were found in stomachs from dogs in both groups. This study could not correlate occurrence of Helicobacter spp to occurrence of gastrointestinal disease. |
| format | L3 |
| id | RepoSLU11123 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2007 |
| publishDateSort | 2007 |
| publisher | SLU/Dept. of Animal Environment and Health (until 231231) |
| publisherStr | SLU/Dept. of Animal Environment and Health (until 231231) |
| record_format | eprints |
| spelling | RepoSLU111232017-09-28T08:23:25Z Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp Lindell, Elin helicobacter gastrit kräkningar gastroenterit bakterier It is well known that dogs often have Helicobacter spp in their stomach. The importance of these bacteria in the development of gastrointestinal disease in dogs is still unknown. In humans, Helicobacter pylori is a causative agent of chronic gastritis and gastric ulcers. In contrast to humans, dogs seldom harbour naturally acquired H. pylori. Instead they are more often colonized by other Helicobacter spp, like Helicobacter bizzozeroni, Helicobacter salomonis and Helicobacter felis. Usually different species are present simultaneously, which makes it difficult to know if some species are responsible for the symptoms or if all species are normal inhabitants of the stomach. The widespread occurrence of Helicobacter spp in dogs also makes it difficult to find bacteria-free control groups. Despite the uncertainty about the role of Helicobacter spp in the pathogenesis of gastritis, there are treatment recommendations in the literature, often combinations of antibiotics and antacids. This investigation is part of a larger study, with the aim to identify Helicobacter spp in stomach, saliva and faeces in healthy dogs and in dogs with signs of gastrointestinal disease. In addition, the histopathological appearance of the stomach was investigated, and correlated to presence of Helicobacter spp. The occurrence of Helicobacter spp in the stomach and the histopathological appearance of the mucosa were investigated in 7 family dogs with signs of gastrointestinal disease and in 5 healthy colony dogs without signs of gastrointestinal disease. The presence of Helicobacter spp in saliva and faeces was investigated in the two groups and in 17 healthy family dogs without signs of gastrointestinal disease. Helicobacter-bacteria were identified with polymerase chain reaction (PCR) and light microscopy of histological sections. The results show that Helicobacter spp are common in saliva, faeces and gastric mucosa in both healthy dogs and in dogs with signs of gastrointestinal disease. In general, the healthy colony dogs showed higher degree of abnormal histopathological findings than did the dogs with signs of gastrointestinal disease. Helicobacter spp were found in stomachs from dogs in both groups. This study could not correlate occurrence of Helicobacter spp to occurrence of gastrointestinal disease. Man vet att hundar härbärgerar Helicobacter spp i magsäcken. Det är dock inte klarlagt vilken betydelse dessa bakterier har för utveckling av sjukdom i mage och tarm hos hund. Hos människa spelar Helicobacter pylori en viktig roll för utveckling av gastrit och ulcus ventriculi. Hundar har, till skillnad från människa, sällan naturlig förekomst av H. pylori, istället dominerar andra arter såsom Helicobacter bizzozeroni, Helicobacter salomonis och Helicobacter felis. Ofta ses flera arter samtidigt, vilket gör det svårt att veta om några arter eventuellt ger upphov till symptom eller om alla arter är normalflora. Den utbredda förekomsten av helicobacterbakterier hos hund gör det dessutom komplicerat att hitta bakteriefria kontrollgrupper. Trots ovissheten om vad Helicobacter spp betyder för patogenesen vid gastrit, finns behandlingsrekommendationer i form av olika kombinationer av antibiotika och syrareglerande farmaka i litteraturen. Denna undersökning är en del av en större studie med syfte att kartlägga förekomsten av helicobacterbakterier i magsäck, saliv och feces hos friska hundar samt hos hundar med symptom på gastrointestinal sjukdom, för att se om grupperna skiljer sig åt. Målsättningen är också att karaktärisera den histopatologiska bilden i magsäcken hos friska hundar och hundar med symptom på gastrointestinal sjukdom och korrelera den till förekomst av Helicobacter spp och helicobacterart. Förekomsten av helicobacterbakterier i magsäcken och magsäckens histopatologiska bild undersöktes hos 7 familje/sällskapshundar med kroniska kräkningar samt hos 5 undervisningshundar utan symptom på gastrointestinal sjukdom. Helicobacterförekomst i saliv och avföring undersöktes hos hundarna i de båda grupperna samt hos ytterligare 17 friska familje/sällskapshundar. Helicobacterbakterier påvisades med polymerase chain reaction (PCR) och med ljusmikroskopisk undersökning av histologiska snitt från magsäcken. Resultaten visar att Helicobacter spp är vanligt förekommande hos både friska hundar och hundar med symptom på gastrointestinal sjukdom. De friska undervisninghundarna hade generellt mer höggradiga histopatologiska förändringar i sina magsäcksbiopsier än hundarna med symptom på gastrointestinal sjukdom. Helicobacter spp fanns i magsäcken hos hundar från båda grupperna. I den här studien kunde förekomst av Helicobacter spp således inte korreleras till sjukdom. SLU/Dept. of Animal Environment and Health (until 231231) 2007 L3 swe eng https://stud.epsilon.slu.se/11123/ |
| spellingShingle | helicobacter gastrit kräkningar gastroenterit bakterier Lindell, Elin Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title | Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title_full | Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title_fullStr | Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title_full_unstemmed | Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title_short | Kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av Helicobacter spp |
| title_sort | kronisk gastroenterit hos hund med avseende på histopatologisk bild och förekomst av helicobacter spp |
| topic | helicobacter gastrit kräkningar gastroenterit bakterier |