Modeling cell size regulation under complex and dynamic environments

In nature, cells face changes in environmental conditions that can modify their growth rate. In these dynamic environments, recent experiments found changes in cell size regulation. Currently, there are few clues about the origin of these cell size changes. In this work, we model cell division as a...

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Autores principales:	Nieto, Cesar, Vargas García, Cesar, Pedraza, Juan Manuel, Singh, Abhyudai
Formato:	article
Lenguaje:	Inglés
Publicado:	Cold Sprimg Harbor Laboratory - CSH 2024
Materias:	Investigación agropecuaria - A50 Célula Medio ambiente Tasa de crecimiento Termorregulación Transversal http://aims.fao.org/aos/agrovoc/c_1418 http://aims.fao.org/aos/agrovoc/c_2593 http://aims.fao.org/aos/agrovoc/c_16130 http://aims.fao.org/aos/agrovoc/c_7722
Acceso en línea:	https://www.biorxiv.org/content/10.1101/2022.09.09.507356v1.article-info http://hdl.handle.net/20.500.12324/40334 https://doi.org/10.1101/2022.09.09.507356

id	RepoAGROSAVIA40334
record_format	dspace
institution	Corporación Colombiana de Investigación Agropecuaria
collection	Repositorio AGROSAVIA
language	Inglés
topic	Investigación agropecuaria - A50 Célula Medio ambiente Tasa de crecimiento Termorregulación Transversal http://aims.fao.org/aos/agrovoc/c_1418 http://aims.fao.org/aos/agrovoc/c_2593 http://aims.fao.org/aos/agrovoc/c_16130 http://aims.fao.org/aos/agrovoc/c_7722
spellingShingle	Investigación agropecuaria - A50 Célula Medio ambiente Tasa de crecimiento Termorregulación Transversal http://aims.fao.org/aos/agrovoc/c_1418 http://aims.fao.org/aos/agrovoc/c_2593 http://aims.fao.org/aos/agrovoc/c_16130 http://aims.fao.org/aos/agrovoc/c_7722 Nieto, Cesar Vargas García, Cesar Pedraza, Juan Manuel Singh, Abhyudai Modeling cell size regulation under complex and dynamic environments
description	In nature, cells face changes in environmental conditions that can modify their growth rate. In these dynamic environments, recent experiments found changes in cell size regulation. Currently, there are few clues about the origin of these cell size changes. In this work, we model cell division as a stochastic process that occurs at a rate proportional to the size. We propose that this rate is zero if the cell is smaller than a minimum size. We show how this model predicts some of the properties found in cell size regulation. For example, among our predictions, we found that the mean cell size is an exponential function of the growth rate under steady conditions. We predict that cells become smaller and the way the division strategy changes during dynamic nutrient depletion. Finally, we use the model to predict cell regulation in an arbitrary complex dynamic environment.
format	article
author	Nieto, Cesar Vargas García, Cesar Pedraza, Juan Manuel Singh, Abhyudai
author_facet	Nieto, Cesar Vargas García, Cesar Pedraza, Juan Manuel Singh, Abhyudai
author_sort	Nieto, Cesar
title	Modeling cell size regulation under complex and dynamic environments
title_short	Modeling cell size regulation under complex and dynamic environments
title_full	Modeling cell size regulation under complex and dynamic environments
title_fullStr	Modeling cell size regulation under complex and dynamic environments
title_full_unstemmed	Modeling cell size regulation under complex and dynamic environments
title_sort	modeling cell size regulation under complex and dynamic environments
publisher	Cold Sprimg Harbor Laboratory - CSH
publishDate	2024
url	https://www.biorxiv.org/content/10.1101/2022.09.09.507356v1.article-info http://hdl.handle.net/20.500.12324/40334 https://doi.org/10.1101/2022.09.09.507356
work_keys_str_mv	AT nietocesar modelingcellsizeregulationundercomplexanddynamicenvironments AT vargasgarciacesar modelingcellsizeregulationundercomplexanddynamicenvironments AT pedrazajuanmanuel modelingcellsizeregulationundercomplexanddynamicenvironments AT singhabhyudai modelingcellsizeregulationundercomplexanddynamicenvironments
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spelling	RepoAGROSAVIA403342024-10-30T03:00:47Z Modeling cell size regulation under complex and dynamic environments Modeling cell size regulation under complex and dynamic environments Nieto, Cesar Vargas García, Cesar Pedraza, Juan Manuel Singh, Abhyudai Investigación agropecuaria - A50 Célula Medio ambiente Tasa de crecimiento Termorregulación Transversal http://aims.fao.org/aos/agrovoc/c_1418 http://aims.fao.org/aos/agrovoc/c_2593 http://aims.fao.org/aos/agrovoc/c_16130 http://aims.fao.org/aos/agrovoc/c_7722 In nature, cells face changes in environmental conditions that can modify their growth rate. In these dynamic environments, recent experiments found changes in cell size regulation. Currently, there are few clues about the origin of these cell size changes. In this work, we model cell division as a stochastic process that occurs at a rate proportional to the size. We propose that this rate is zero if the cell is smaller than a minimum size. We show how this model predicts some of the properties found in cell size regulation. For example, among our predictions, we found that the mean cell size is an exponential function of the growth rate under steady conditions. We predict that cells become smaller and the way the division strategy changes during dynamic nutrient depletion. Finally, we use the model to predict cell regulation in an arbitrary complex dynamic environment. 2024-10-29T20:07:30Z 2024-10-29T20:07:30Z 2022-09-13 2022 article Artículo científico http://purl.org/coar/resource_type/c_2df8fbb1 info:eu-repo/semantics/article https://purl.org/redcol/resource_type/ART http://purl.org/coar/version/c_970fb48d4fbd8a85 https://www.biorxiv.org/content/10.1101/2022.09.09.507356v1.article-info http://hdl.handle.net/20.500.12324/40334 https://doi.org/10.1101/2022.09.09.507356 reponame:Biblioteca Digital Agropecuaria de Colombia instname:Corporación colombiana de investigación agropecuaria AGROSAVIA eng BioRxiv 1 1 1 8 Amir, A. (2014). Cell size regulation in bacteria. Physical review letters, 112(20), 208102. Bakshi, S., Leoncini, E., Baker, C., Ca˜nas-Duarte, S.J., Okumus, B., and Paulsson, J. (2021). Tracking bacterial lineages in complex and dynamic environments with applications for growth control and persistence. Nature Microbiology, 6(6), 783–791. 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Modeling cell size regulation under complex and dynamic environments

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