Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle

Inheritance of fertility traits in cattle is complex since they are controlled by multiple loci. Genome-wide association studies are an efficient tool to detect genomic regions that explain the phenotypic variation for a trait of interest. The aim of this study was to identify genomic regions that a...

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Main Authors:	Fernandez Niño, Juan Carlos, Perez Garcia, Juan Esteban, Herrera, N., Martinez Sarmiento, Rodrigo Alfredo, Bejarano Garavito, Diego Hernan, Martinez Rocha, Juan Felipe
Format:	article
Language:	Inglés
Published:	Fundação de Pesquisas Científicas de Ribeirão Preto - FUNPEC-RP 2024
Subjects:	Genética y mejoramiento animal - L10 Ganado bovino Parto Fertilidad Propiedad biológica Ganadería y especies menores http://aims.fao.org/aos/agrovoc/c_1391 http://aims.fao.org/aos/agrovoc/c_5604 http://aims.fao.org/aos/agrovoc/c_2862 http://aims.fao.org/aos/agrovoc/c_1501
Online Access:	http://hdl.handle.net/20.500.12324/40176 http://dx.doi.org/10.4238/gmr18258

id	RepoAGROSAVIA40176
record_format	dspace
institution	Corporación Colombiana de Investigación Agropecuaria
collection	Repositorio AGROSAVIA
language	Inglés
topic	Genética y mejoramiento animal - L10 Ganado bovino Parto Fertilidad Propiedad biológica Ganadería y especies menores http://aims.fao.org/aos/agrovoc/c_1391 http://aims.fao.org/aos/agrovoc/c_5604 http://aims.fao.org/aos/agrovoc/c_2862 http://aims.fao.org/aos/agrovoc/c_1501
spellingShingle	Genética y mejoramiento animal - L10 Ganado bovino Parto Fertilidad Propiedad biológica Ganadería y especies menores http://aims.fao.org/aos/agrovoc/c_1391 http://aims.fao.org/aos/agrovoc/c_5604 http://aims.fao.org/aos/agrovoc/c_2862 http://aims.fao.org/aos/agrovoc/c_1501 Fernandez Niño, Juan Carlos Perez Garcia, Juan Esteban Herrera, N. Martinez Sarmiento, Rodrigo Alfredo Bejarano Garavito, Diego Hernan Martinez Rocha, Juan Felipe Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
description	Inheritance of fertility traits in cattle is complex since they are controlled by multiple loci. Genome-wide association studies are an efficient tool to detect genomic regions that explain the phenotypic variation for a trait of interest. The aim of this study was to identify genomic regions that affect the age at first calving (AFC) and the calving interval (CI) in the Romosinuano (ROMO) and Costeño con Cuernos (CCC) creole cattle breeds and nominate candidate genes that influence these reproductive traits. AFC and CI records were obtained from 4,063 ROMO and 3,922 CCC, and a total of 962 animals were genotyped using the BovineSNP50. Based on the single-step GBLUP methodology, the effects of 54K single nucleotide polymorphisms (SNPs) were grouped within windows of eight adjacent SNPs to explain the genetic variance. Sixty-six SNP windows were significantly associated with AFC (31 regions) and CI (35 regions). Of these regions, 17 were associated with AFC in ROMO, 14 with AFC in CCC, 17 with CI in ROMO and 18 with CI in CCC. From these, nine candidate genes (CACNA1A, CACNA1D, CACTIN, IARS2, PGRMC2, PTGDR, SYT10, UBE4A, RNF17) were identified as possible candidates involved in molecular mechanism that affect physiological mechanisms, such as hormonal regulation, ovarian cyclicity, growth rate, gametogenesis, acceleration of puberty, regulation of immune system, early embryonic development and the pathways to embryo-maternal recognition and maintenance of pregnancy. Furthermore, some genomic regions located in BTA1, BTA5 and BTA14 showed a pleiotropic effect on both AFC and CI. The polymorphisms identified in this study can help determine gene networks involved in the physiology of reproduction in cattle and to explain the inherent genetic variance of traits that measure reproductive performance in cattle. Some of these polymorphisms might be considered for breeding selection strategies to improve complex traits such as AFC and CI in beef and dairy cattle production systems.
format	article
author	Fernandez Niño, Juan Carlos Perez Garcia, Juan Esteban Herrera, N. Martinez Sarmiento, Rodrigo Alfredo Bejarano Garavito, Diego Hernan Martinez Rocha, Juan Felipe
author_facet	Fernandez Niño, Juan Carlos Perez Garcia, Juan Esteban Herrera, N. Martinez Sarmiento, Rodrigo Alfredo Bejarano Garavito, Diego Hernan Martinez Rocha, Juan Felipe
author_sort	Fernandez Niño, Juan Carlos
title	Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
title_short	Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
title_full	Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
title_fullStr	Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
title_full_unstemmed	Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
title_sort	genomic association study for age at first calving and calving interval in romosinuano and costeño con cuernos cattle
publisher	Fundação de Pesquisas Científicas de Ribeirão Preto - FUNPEC-RP
publishDate	2024
url	http://hdl.handle.net/20.500.12324/40176 http://dx.doi.org/10.4238/gmr18258
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spelling	RepoAGROSAVIA401762024-09-25T03:00:47Z Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle Fernandez Niño, Juan Carlos Perez Garcia, Juan Esteban Herrera, N. Martinez Sarmiento, Rodrigo Alfredo Bejarano Garavito, Diego Hernan Martinez Rocha, Juan Felipe Genética y mejoramiento animal - L10 Ganado bovino Parto Fertilidad Propiedad biológica Ganadería y especies menores http://aims.fao.org/aos/agrovoc/c_1391 http://aims.fao.org/aos/agrovoc/c_5604 http://aims.fao.org/aos/agrovoc/c_2862 http://aims.fao.org/aos/agrovoc/c_1501 Inheritance of fertility traits in cattle is complex since they are controlled by multiple loci. Genome-wide association studies are an efficient tool to detect genomic regions that explain the phenotypic variation for a trait of interest. The aim of this study was to identify genomic regions that affect the age at first calving (AFC) and the calving interval (CI) in the Romosinuano (ROMO) and Costeño con Cuernos (CCC) creole cattle breeds and nominate candidate genes that influence these reproductive traits. AFC and CI records were obtained from 4,063 ROMO and 3,922 CCC, and a total of 962 animals were genotyped using the BovineSNP50. Based on the single-step GBLUP methodology, the effects of 54K single nucleotide polymorphisms (SNPs) were grouped within windows of eight adjacent SNPs to explain the genetic variance. Sixty-six SNP windows were significantly associated with AFC (31 regions) and CI (35 regions). Of these regions, 17 were associated with AFC in ROMO, 14 with AFC in CCC, 17 with CI in ROMO and 18 with CI in CCC. From these, nine candidate genes (CACNA1A, CACNA1D, CACTIN, IARS2, PGRMC2, PTGDR, SYT10, UBE4A, RNF17) were identified as possible candidates involved in molecular mechanism that affect physiological mechanisms, such as hormonal regulation, ovarian cyclicity, growth rate, gametogenesis, acceleration of puberty, regulation of immune system, early embryonic development and the pathways to embryo-maternal recognition and maintenance of pregnancy. Furthermore, some genomic regions located in BTA1, BTA5 and BTA14 showed a pleiotropic effect on both AFC and CI. The polymorphisms identified in this study can help determine gene networks involved in the physiology of reproduction in cattle and to explain the inherent genetic variance of traits that measure reproductive performance in cattle. Some of these polymorphisms might be considered for breeding selection strategies to improve complex traits such as AFC and CI in beef and dairy cattle production systems. Corporación colombiana de investigación agropecuaria - AGROSAVIA Instituto Colombiano Agropecuario - ICA Ministerio de Agricultura y Desarrollo Rural - MADR Ganadería bovina 2024-09-24T18:54:32Z 2024-09-24T18:54:32Z 2019-05-03 2019 article Artículo científico http://purl.org/coar/resource_type/c_2df8fbb1 info:eu-repo/semantics/article https://purl.org/redcol/resource_type/ART http://purl.org/coar/version/c_970fb48d4fbd8a85 chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://geneticsmr.com/wp-content/uploads/2024/03/18-2-gmr18258.pdf 1676-5680 http://hdl.handle.net/20.500.12324/40176 http://dx.doi.org/10.4238/gmr18258 reponame:Biblioteca Digital Agropecuaria de Colombia instname:Corporación colombiana de investigación agropecuaria AGROSAVIA eng Genetics and Molecular Research 18 2 1 13 Aguilar I, Misztal I, Johnson DL, Legarra A, et al. (2010). 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Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle

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