Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit
Gonadotropin-releasing hormone (GnRH) -supplemented extenders have emerged as a welfare-orientated method to induce ovulation in the artificial insemination (AI) of rabbits. The main factor that limits the bioavailability of GnRH analogue on intravaginal administration is the proteolytic activ...
| Main Authors: | , , , |
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| Format: | article |
| Language: | Español |
| Published: |
Wiley
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/20.500.11939/9001 https://onlinelibrary.wiley.com/doi/full/10.1111/rda.14584 |
| _version_ | 1855032893526507520 |
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| author | Viudes-De-Castro, María P. Marco-Jiménez, Francisco Miralles-Bover, H. Vicente, José S. |
| author_browse | Marco-Jiménez, Francisco Miralles-Bover, H. Vicente, José S. Viudes-De-Castro, María P. |
| author_facet | Viudes-De-Castro, María P. Marco-Jiménez, Francisco Miralles-Bover, H. Vicente, José S. |
| author_sort | Viudes-De-Castro, María P. |
| collection | ReDivia |
| description | Gonadotropin-releasing
hormone (GnRH) -supplemented
extenders have emerged as
a welfare-orientated
method to induce ovulation in the artificial insemination (AI) of
rabbits. The main factor that limits the bioavailability of GnRH analogue on intravaginal
administration is the proteolytic activity of enzymes present in rabbit seminal
plasma. The use of GnRH analogues with higher biological potency would allow us to
decrease their concentration in the seminal dose without compromising effectiveness.
The current study was designed to assess the efficacy of various GnRH analogues
concerning their ability to induce ovulation in rabbit AI. The base solution used
for experimental extenders contained an aminopeptidase inhibitor. Four experimental
groups were used, females from the Control group were induced to ovulate with an
intramuscular administration of 1 μg of buserelin, while in the other three groups females
received an intravaginal administration of 3.5 μg of buserelin (BUS), deslorelin
(DES) or fertirelin (FER) within the seminal dose. Results showed that the ovulation
frequency was similar in all groups studied. A concentration of 3.5 μg of the different
GnRH analogues tested in this study showed similar potency in inducing ovulation in
non-lactating
females, yielding comparable results in terms of pregnancy rate at birth
and prolificacy. |
| format | article |
| id | ReDivia9001 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Español |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | ReDivia90012025-04-25T14:49:36Z Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit Viudes-De-Castro, María P. Marco-Jiménez, Francisco Miralles-Bover, H. Vicente, José S. GnRH analogues L53 Animal physiology - Reproduction Induced ovulation Artificial insemination Gonadotropin-releasing hormone (GnRH) -supplemented extenders have emerged as a welfare-orientated method to induce ovulation in the artificial insemination (AI) of rabbits. The main factor that limits the bioavailability of GnRH analogue on intravaginal administration is the proteolytic activity of enzymes present in rabbit seminal plasma. The use of GnRH analogues with higher biological potency would allow us to decrease their concentration in the seminal dose without compromising effectiveness. The current study was designed to assess the efficacy of various GnRH analogues concerning their ability to induce ovulation in rabbit AI. The base solution used for experimental extenders contained an aminopeptidase inhibitor. Four experimental groups were used, females from the Control group were induced to ovulate with an intramuscular administration of 1 μg of buserelin, while in the other three groups females received an intravaginal administration of 3.5 μg of buserelin (BUS), deslorelin (DES) or fertirelin (FER) within the seminal dose. Results showed that the ovulation frequency was similar in all groups studied. A concentration of 3.5 μg of the different GnRH analogues tested in this study showed similar potency in inducing ovulation in non-lactating females, yielding comparable results in terms of pregnancy rate at birth and prolificacy. 2024-11-04T13:17:45Z 2024-11-04T13:17:45Z 2024 article acceptedVersion Viudes‐de‐Castro, M. P., Marco‐Jiménez, F., Miralles‐Bover, H., & Vicente, J. S. (2024). Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit. Reproduction in Domestic Animals, 59, e14584. https://hdl.handle.net/20.500.11939/9001 10.1111/rda.14584 https://onlinelibrary.wiley.com/doi/full/10.1111/rda.14584 es info:eu-repo/grantAgreement/ERDF/PCV 2021-2027/52201/ES/Relanzando la agroalimentación valenciana para una producción y consumo sostenibles y seguros/AgroAlimVal info:eu-repo/grantAgreement/AEI/Programa Estatal de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i/PID2021-127867OB-100 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess Wiley electronico |
| spellingShingle | GnRH analogues L53 Animal physiology - Reproduction Induced ovulation Artificial insemination Viudes-De-Castro, María P. Marco-Jiménez, Francisco Miralles-Bover, H. Vicente, José S. Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title | Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title_full | Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title_fullStr | Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title_full_unstemmed | Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title_short | Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit |
| title_sort | potency evaluation of different gnrh analogues on ovulation induction and reproductive performance of doe rabbit |
| topic | GnRH analogues L53 Animal physiology - Reproduction Induced ovulation Artificial insemination |
| url | https://hdl.handle.net/20.500.11939/9001 https://onlinelibrary.wiley.com/doi/full/10.1111/rda.14584 |
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