Potency evaluation of different GNRH analogues on ovulation induction and reproductive performance of doe rabbit
Gonadotropin-releasing hormone (GnRH) -supplemented extenders have emerged as a welfare-orientated method to induce ovulation in the artificial insemination (AI) of rabbits. The main factor that limits the bioavailability of GnRH analogue on intravaginal administration is the proteolytic activ...
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | Español |
| Publicado: |
Wiley
2024
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/20.500.11939/9001 https://onlinelibrary.wiley.com/doi/full/10.1111/rda.14584 |
| Sumario: | Gonadotropin-releasing
hormone (GnRH) -supplemented
extenders have emerged as
a welfare-orientated
method to induce ovulation in the artificial insemination (AI) of
rabbits. The main factor that limits the bioavailability of GnRH analogue on intravaginal
administration is the proteolytic activity of enzymes present in rabbit seminal
plasma. The use of GnRH analogues with higher biological potency would allow us to
decrease their concentration in the seminal dose without compromising effectiveness.
The current study was designed to assess the efficacy of various GnRH analogues
concerning their ability to induce ovulation in rabbit AI. The base solution used
for experimental extenders contained an aminopeptidase inhibitor. Four experimental
groups were used, females from the Control group were induced to ovulate with an
intramuscular administration of 1 μg of buserelin, while in the other three groups females
received an intravaginal administration of 3.5 μg of buserelin (BUS), deslorelin
(DES) or fertirelin (FER) within the seminal dose. Results showed that the ovulation
frequency was similar in all groups studied. A concentration of 3.5 μg of the different
GnRH analogues tested in this study showed similar potency in inducing ovulation in
non-lactating
females, yielding comparable results in terms of pregnancy rate at birth
and prolificacy. |
|---|