The role of horizontal gene transfer in Staphylococcus aureus host adaptation
Staphylococcus aureus is an important human pathogen that also causes economically important infections of livestock. In a recent paper, we employed a population genomic approach to investigate the molecular basis of ruminant host adaptation by S. aureus. The data suggest that the common path...
| Autores principales: | , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | http://hdl.handle.net/20.500.11939/6902 https://www.tandfonline.com/doi/abs/10.4161/viru.2.3.16193 |
| _version_ | 1855492174025588736 |
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| author | Guinane, Caitriona M. Penadés, José R. Fitzgerald, J. Ross |
| author_browse | Fitzgerald, J. Ross Guinane, Caitriona M. Penadés, José R. |
| author_facet | Guinane, Caitriona M. Penadés, José R. Fitzgerald, J. Ross |
| author_sort | Guinane, Caitriona M. |
| collection | ReDivia |
| description | Staphylococcus aureus is an important
human pathogen that also causes economically
important infections of livestock.
In a recent paper, we employed a
population genomic approach to investigate
the molecular basis of ruminant host
adaptation by S. aureus. The data suggest
that the common pathogenic clone
associated with small ruminants originated
in humans but has since adapted
to its adopted host through a combination
of allelic diversification, gene loss
and acquisition of mobile genetic elements.
In particular, a new subfamily
of staphylococcal pathogenicity islands
(SaPI) was identified encoding a novel
von Willebrand factor-binding protein
(vWBP) with ruminant-specific coagulase
activity. The wide distribution of
vWBP-encoding SaPIs among ruminant
strains implies an important role in hostadaptation.
In the current article we
summarize the findings of the paper and
comment on the implications of the study
for our understanding of the molecular
basis of bacterial host adaptation |
| format | Artículo |
| id | ReDivia6902 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | dspace |
| spelling | ReDivia69022025-04-25T14:47:55Z The role of horizontal gene transfer in Staphylococcus aureus host adaptation Guinane, Caitriona M. Penadés, José R. Fitzgerald, J. Ross Host-adaptation Pathogenicity island L73 Animal diseases L70 Veterinary science and hygiene Staphylococcus Ruminants Humans Staphylococcus aureus is an important human pathogen that also causes economically important infections of livestock. In a recent paper, we employed a population genomic approach to investigate the molecular basis of ruminant host adaptation by S. aureus. The data suggest that the common pathogenic clone associated with small ruminants originated in humans but has since adapted to its adopted host through a combination of allelic diversification, gene loss and acquisition of mobile genetic elements. In particular, a new subfamily of staphylococcal pathogenicity islands (SaPI) was identified encoding a novel von Willebrand factor-binding protein (vWBP) with ruminant-specific coagulase activity. The wide distribution of vWBP-encoding SaPIs among ruminant strains implies an important role in hostadaptation. In the current article we summarize the findings of the paper and comment on the implications of the study for our understanding of the molecular basis of bacterial host adaptation 2020-12-17T12:56:02Z 2020-12-17T12:56:02Z 2011 article publishedVersion Guinane, C. M., Penadés, J. R., & Fitzgerald, J. R. (2011). The role of horizontal gene transfer in Staphylococcus aureus host adaptation. Virulence, 2(3), 241-243. 2150-5594 (print) 2150-5608 (web) http://hdl.handle.net/20.500.11939/6902 10.4161/viru.2.3.16193 https://www.tandfonline.com/doi/abs/10.4161/viru.2.3.16193 en Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ openAccess Taylor & Francis electronico |
| spellingShingle | Host-adaptation Pathogenicity island L73 Animal diseases L70 Veterinary science and hygiene Staphylococcus Ruminants Humans Guinane, Caitriona M. Penadés, José R. Fitzgerald, J. Ross The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title | The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title_full | The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title_fullStr | The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title_full_unstemmed | The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title_short | The role of horizontal gene transfer in Staphylococcus aureus host adaptation |
| title_sort | role of horizontal gene transfer in staphylococcus aureus host adaptation |
| topic | Host-adaptation Pathogenicity island L73 Animal diseases L70 Veterinary science and hygiene Staphylococcus Ruminants Humans |
| url | http://hdl.handle.net/20.500.11939/6902 https://www.tandfonline.com/doi/abs/10.4161/viru.2.3.16193 |
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