A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat tohuman and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Follow...
| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | Inglés |
| Publicado: |
AAAS (American Asociation for the Advancement of Science)
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.11939/6473 https://advances.sciencemag.org/content/5/11/eaax0063 |
| _version_ | 1855032433358929920 |
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| author | Bacigalupe, Rodrigo Tormo-Mas, María A. Penadés, José R. Fitzgerald, J. Ross |
| author_browse | Bacigalupe, Rodrigo Fitzgerald, J. Ross Penadés, José R. Tormo-Mas, María A. |
| author_facet | Bacigalupe, Rodrigo Tormo-Mas, María A. Penadés, José R. Fitzgerald, J. Ross |
| author_sort | Bacigalupe, Rodrigo |
| collection | ReDivia |
| description | While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches,
leading to the emergence of new clones that are a threat tohuman and animal health. However, the bacterial traits that
underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are
influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the
capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate
the ability of themultihost pathogen Staphylococcus aureus to adapt to new species under continuous population
bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and
sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some
bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces. |
| format | article |
| id | ReDivia6473 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | AAAS (American Asociation for the Advancement of Science) |
| publisherStr | AAAS (American Asociation for the Advancement of Science) |
| record_format | dspace |
| spelling | ReDivia64732025-04-25T14:47:12Z A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species Bacigalupe, Rodrigo Tormo-Mas, María A. Penadés, José R. Fitzgerald, J. Ross L73 Animal diseases Pathogenic bacteria Infectious diseases While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat tohuman and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of themultihost pathogen Staphylococcus aureus to adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces. 2020-05-27T08:58:17Z 2020-05-27T08:58:17Z 2019 article publishedVersion Bacigalupe, R., Tormo-Mas, M. Á., Penadés, J. R., & Fitzgerald, J. R. (2019). A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science advances, 5(11), eaax0063. 2375-2548 http://hdl.handle.net/20.500.11939/6473 10.1126/sciadv.aax0063 https://advances.sciencemag.org/content/5/11/eaax0063 en Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ AAAS (American Asociation for the Advancement of Science) electronico |
| spellingShingle | L73 Animal diseases Pathogenic bacteria Infectious diseases Bacigalupe, Rodrigo Tormo-Mas, María A. Penadés, José R. Fitzgerald, J. Ross A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title | A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title_full | A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title_fullStr | A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title_full_unstemmed | A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title_short | A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| title_sort | multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species |
| topic | L73 Animal diseases Pathogenic bacteria Infectious diseases |
| url | http://hdl.handle.net/20.500.11939/6473 https://advances.sciencemag.org/content/5/11/eaax0063 |
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