Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that beta-lactams...
| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Acceso en línea: | http://hdl.handle.net/20.500.11939/5551 |
| _version_ | 1855032296646639616 |
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| author | Maiques, Elisa Ubeda, Carles Campoy, Susana Salvador, N. Lasa, Inigo Novick, Richard P. Barbe, Jordi Penadés, José R. |
| author_browse | Barbe, Jordi Campoy, Susana Lasa, Inigo Maiques, Elisa Novick, Richard P. Penadés, José R. Salvador, N. Ubeda, Carles |
| author_facet | Maiques, Elisa Ubeda, Carles Campoy, Susana Salvador, N. Lasa, Inigo Novick, Richard P. Barbe, Jordi Penadés, José R. |
| author_sort | Maiques, Elisa |
| collection | ReDivia |
| description | Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that beta-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that beta-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, beta-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. |
| format | article |
| id | ReDivia5551 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| record_format | dspace |
| spelling | ReDivia55512025-04-25T14:43:16Z Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus Maiques, Elisa Ubeda, Carles Campoy, Susana Salvador, N. Lasa, Inigo Novick, Richard P. Barbe, Jordi Penadés, José R. Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that beta-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that beta-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, beta-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. 2017-06-01T10:12:33Z 2017-06-01T10:12:33Z 2006 APR 2006 article Maiques, E., Ubeda, C., Campoy, S., Salvador, N., Lasa, I., Novick, R. P., Barbe, J., Penades, J.R. (2006). Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus. Journal of Bacteriology, 188(7), 2726-2729. 0021-9193 http://hdl.handle.net/20.500.11939/5551 10.1128/JB.188.7.2726-2729.2006 en openAccess Impreso |
| spellingShingle | Maiques, Elisa Ubeda, Carles Campoy, Susana Salvador, N. Lasa, Inigo Novick, Richard P. Barbe, Jordi Penadés, José R. Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title_full | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title_fullStr | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title_full_unstemmed | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title_short | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus |
| title_sort | beta lactam antibiotics induce the sos response and horizontal transfer of virulence factors in staphylococcus aureus |
| url | http://hdl.handle.net/20.500.11939/5551 |
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