A single natural nucleotide mutation alters bacterial pathogen host tropism
The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary t...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Acceso en línea: | http://hdl.handle.net/20.500.11939/4704 https://www.nature.com/articles/ng.3219 |
| _version_ | 1855491800688492544 |
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| author | Viana, David Comos, Maria McAdam, Paul R. Ward, Melissa J. Selva, Laura Guinane, Caitriona M. Gonzalez-Munoz, Beatriz M. Tristan, Anne Foster, Simon J. Fitzgerald, J. Ross Penadés, José R. |
| author_browse | Comos, Maria Fitzgerald, J. Ross Foster, Simon J. Gonzalez-Munoz, Beatriz M. Guinane, Caitriona M. McAdam, Paul R. Penadés, José R. Selva, Laura Tristan, Anne Viana, David Ward, Melissa J. |
| author_facet | Viana, David Comos, Maria McAdam, Paul R. Ward, Melissa J. Selva, Laura Guinane, Caitriona M. Gonzalez-Munoz, Beatriz M. Tristan, Anne Foster, Simon J. Fitzgerald, J. Ross Penadés, José R. |
| author_sort | Viana, David |
| collection | ReDivia |
| description | The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the common rabbit clone of Staphylococcus aureus. We report that it evolved through a likely human-to-rabbit host jump over 40 years ago and that only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits. Related mutations were identified at the same locus in other rabbit strains of distinct clonal origin, consistent with convergent evolution. This first report of a single mutation that was sufficient to alter the host tropism of a microorganism during its evolution highlights the capacity of some pathogens to readily expand into new host species populations. |
| format | Artículo |
| id | ReDivia4704 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| record_format | dspace |
| spelling | ReDivia47042025-04-25T14:44:12Z A single natural nucleotide mutation alters bacterial pathogen host tropism Viana, David Comos, Maria McAdam, Paul R. Ward, Melissa J. Selva, Laura Guinane, Caitriona M. Gonzalez-Munoz, Beatriz M. Tristan, Anne Foster, Simon J. Fitzgerald, J. Ross Penadés, José R. The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the common rabbit clone of Staphylococcus aureus. We report that it evolved through a likely human-to-rabbit host jump over 40 years ago and that only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits. Related mutations were identified at the same locus in other rabbit strains of distinct clonal origin, consistent with convergent evolution. This first report of a single mutation that was sufficient to alter the host tropism of a microorganism during its evolution highlights the capacity of some pathogens to readily expand into new host species populations. 2017-06-01T10:10:47Z 2017-06-01T10:10:47Z 2015 APR 2015 article Viana, D., Comos, M., McAdam, P. R., Ward, M. J., Selva, L., Guinane, C. M. et al. (2015). A single natural nucleotide mutation alters bacterial pathogen host tropism. Nature genetics, 47(4), 361-366. 1061-4036 http://hdl.handle.net/20.500.11939/4704 10.1038/ng.3219 https://www.nature.com/articles/ng.3219 en openAccess Impreso |
| spellingShingle | Viana, David Comos, Maria McAdam, Paul R. Ward, Melissa J. Selva, Laura Guinane, Caitriona M. Gonzalez-Munoz, Beatriz M. Tristan, Anne Foster, Simon J. Fitzgerald, J. Ross Penadés, José R. A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title | A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title_full | A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title_fullStr | A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title_full_unstemmed | A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title_short | A single natural nucleotide mutation alters bacterial pathogen host tropism |
| title_sort | single natural nucleotide mutation alters bacterial pathogen host tropism |
| url | http://hdl.handle.net/20.500.11939/4704 https://www.nature.com/articles/ng.3219 |
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