dUTPases, the unexplored family of signalling molecules
Deciphering the molecular mechanisms that control relevant cellular processes is of utmost importance to understand how viruses, prokaryotic and eukaryotic cells work. The diversity of living organisms suggests that there are novel regulators still to be discovered, which may uncover new regulatory...
| Main Authors: | , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11939/4342 |
| _version_ | 1855491736128716800 |
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| author | Penadés, José R. Donderis, Jorge Garcia-Caballer, Maria Tormo-Mas, María A. Marina, Alberto |
| author_browse | Donderis, Jorge Garcia-Caballer, Maria Marina, Alberto Penadés, José R. Tormo-Mas, María A. |
| author_facet | Penadés, José R. Donderis, Jorge Garcia-Caballer, Maria Tormo-Mas, María A. Marina, Alberto |
| author_sort | Penadés, José R. |
| collection | ReDivia |
| description | Deciphering the molecular mechanisms that control relevant cellular processes is of utmost importance to understand how viruses, prokaryotic and eukaryotic cells work. The diversity of living organisms suggests that there are novel regulators still to be discovered, which may uncover new regulatory paradigms. dUTPases (Duts) are assumed to be ubiquitous enzymes regulating cellular dUTP levels to prevent misincorporation of uracil into DNA. Recently however, Duts have been involved in the control of several relevant cellular processes, including transfer of mobile genetic elements, regulation of the immune system, autoimmunity or apoptosis, suggesting that they perform regulatory functions. This review aims at investigating the unexplored impact of Duts as novel signalling molecules. |
| format | Artículo |
| id | ReDivia4342 |
| institution | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| record_format | dspace |
| spelling | ReDivia43422025-04-25T14:42:53Z dUTPases, the unexplored family of signalling molecules Penadés, José R. Donderis, Jorge Garcia-Caballer, Maria Tormo-Mas, María A. Marina, Alberto Deciphering the molecular mechanisms that control relevant cellular processes is of utmost importance to understand how viruses, prokaryotic and eukaryotic cells work. The diversity of living organisms suggests that there are novel regulators still to be discovered, which may uncover new regulatory paradigms. dUTPases (Duts) are assumed to be ubiquitous enzymes regulating cellular dUTP levels to prevent misincorporation of uracil into DNA. Recently however, Duts have been involved in the control of several relevant cellular processes, including transfer of mobile genetic elements, regulation of the immune system, autoimmunity or apoptosis, suggesting that they perform regulatory functions. This review aims at investigating the unexplored impact of Duts as novel signalling molecules. 2017-06-01T10:09:53Z 2017-06-01T10:09:53Z 2013 APR 2013 article Penades, J.R., Donderis, J., Garcia-Caballer, M., Angeles Tormo-Mas, M., Marina, A. (2013). dUTPases, the unexplored family of signalling molecules. Current opinion in microbiology, 16(2), 163-170. 1369-5274 http://hdl.handle.net/20.500.11939/4342 10.1016/j.mib.2013.02.005 en openAccess Impreso |
| spellingShingle | Penadés, José R. Donderis, Jorge Garcia-Caballer, Maria Tormo-Mas, María A. Marina, Alberto dUTPases, the unexplored family of signalling molecules |
| title | dUTPases, the unexplored family of signalling molecules |
| title_full | dUTPases, the unexplored family of signalling molecules |
| title_fullStr | dUTPases, the unexplored family of signalling molecules |
| title_full_unstemmed | dUTPases, the unexplored family of signalling molecules |
| title_short | dUTPases, the unexplored family of signalling molecules |
| title_sort | dutpases the unexplored family of signalling molecules |
| url | http://hdl.handle.net/20.500.11939/4342 |
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