Intoxication by Astragalus garbancillo var. garbancillo in llamas
Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloi...
| Autores principales: | , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Español |
| Publicado: |
American Association of Veterinary Laboratory Diagnosticians
2021
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/9947 https://journals.sagepub.com/doi/full/10.1177/1040638720914338 https://doi.org/10.1177/1040638720914338 |
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| author | Marín, Raúl Eduardo Micheloud, Juan Francisco Vignales, Nilda D. Gimeno, Eduardo Juan O"Toole, Donal Gardner, Dale R. Woods, Leslie. Uzal, Francisco A. |
| author_browse | Gardner, Dale R. Gimeno, Eduardo Juan Marín, Raúl Eduardo Micheloud, Juan Francisco O"Toole, Donal Uzal, Francisco A. Vignales, Nilda D. Woods, Leslie. |
| author_facet | Marín, Raúl Eduardo Micheloud, Juan Francisco Vignales, Nilda D. Gimeno, Eduardo Juan O"Toole, Donal Gardner, Dale R. Woods, Leslie. Uzal, Francisco A. |
| author_sort | Marín, Raúl Eduardo |
| collection | INTA Digital |
| description | Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo. |
| format | info:ar-repo/semantics/artículo |
| id | INTA9947 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Español |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | American Association of Veterinary Laboratory Diagnosticians |
| publisherStr | American Association of Veterinary Laboratory Diagnosticians |
| record_format | dspace |
| spelling | INTA99472021-08-03T16:52:05Z Intoxication by Astragalus garbancillo var. garbancillo in llamas Marín, Raúl Eduardo Micheloud, Juan Francisco Vignales, Nilda D. Gimeno, Eduardo Juan O"Toole, Donal Gardner, Dale R. Woods, Leslie. Uzal, Francisco A. Astragalus Plantas Tóxicas Llama Envenenamiento Poisonous Plants Llamas Poisoning Astragalus garbancillo Intoxicación Intoxication Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo. EEA Salta Fil: Marín, Raúl E. Universidad Nacional de Jujuy. Facultad de Ciencia Agrarias; Argentina. Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta. Área de Sanidad Animal; Argentina. Fil: Vignale, Nilda D. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina. Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General;Argentina. Fil: O'Toole, Donal. Wyoming State Veterinary Laboratory ; Estados Unidos Fil: Gardner, Dale R. USDA-ARS Poisonous Plant Research Laboratory; Estados Unidos Fil: Woods, Leslies. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System, San Bernardino; Estados Unidos 2021-08-03T16:25:36Z 2021-08-03T16:25:36Z 2020 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/9947 https://journals.sagepub.com/doi/full/10.1177/1040638720914338 1040-6387 1943-4936 https://doi.org/10.1177/1040638720914338 spa info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf American Association of Veterinary Laboratory Diagnosticians Journal of Veterinary Diagnostic Investigation 32 (3) : 467-470 (May 2020) |
| spellingShingle | Astragalus Plantas Tóxicas Llama Envenenamiento Poisonous Plants Llamas Poisoning Astragalus garbancillo Intoxicación Intoxication Marín, Raúl Eduardo Micheloud, Juan Francisco Vignales, Nilda D. Gimeno, Eduardo Juan O"Toole, Donal Gardner, Dale R. Woods, Leslie. Uzal, Francisco A. Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title | Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title_full | Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title_fullStr | Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title_full_unstemmed | Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title_short | Intoxication by Astragalus garbancillo var. garbancillo in llamas |
| title_sort | intoxication by astragalus garbancillo var garbancillo in llamas |
| topic | Astragalus Plantas Tóxicas Llama Envenenamiento Poisonous Plants Llamas Poisoning Astragalus garbancillo Intoxicación Intoxication |
| url | http://hdl.handle.net/20.500.12123/9947 https://journals.sagepub.com/doi/full/10.1177/1040638720914338 https://doi.org/10.1177/1040638720914338 |
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