Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists
Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its abilit...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo
2021
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/9863 https://revistas.uncu.edu.ar/ojs/index.php/RFCA/article/view/4644 https://doi.org/10.48162/rev.39.005 |
| _version_ | 1855484476114599936 |
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| author | Gonzalez, Roxana Elizabeth Soto Vargas, Verónica Carolina Sance, María Mirta Galmarini, Claudio Romulo |
| author_browse | Galmarini, Claudio Romulo Gonzalez, Roxana Elizabeth Sance, María Mirta Soto Vargas, Verónica Carolina |
| author_facet | Gonzalez, Roxana Elizabeth Soto Vargas, Verónica Carolina Sance, María Mirta Galmarini, Claudio Romulo |
| author_sort | Gonzalez, Roxana Elizabeth |
| collection | INTA Digital |
| description | Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist. |
| format | Artículo |
| id | INTA9863 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo |
| publisherStr | Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo |
| record_format | dspace |
| spelling | INTA98632021-07-22T12:06:50Z Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists Gonzalez, Roxana Elizabeth Soto Vargas, Verónica Carolina Sance, María Mirta Galmarini, Claudio Romulo Ajo Allium Sativum Variedades Trombocitos Coagulación Sangre Garlic Varieties Platelets Coagulation Blood Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist. Las plaquetas son componentes esenciales de la sangre humana. Además de su rol normal, las plaquetas pueden estar involucradas en procesos que causan infarto de miocardio, apoplejía y otros trastornos trombóticos. La activación plaquetaria in vivo, invo-lucra una combinación de agonistas. El ajo posee efectos beneficiosos debido a su capacidad para inhibir la agregación plaquetaria y la formación de tromboxano. El objetivo fue evaluar la capacidad de extractos acuosos de ajo de inhibir la agregación plaquetaria inducida por diferentes agonistas y sus mezclas en diferentes donantes. Se encontraron diferencias signi-ficativas en la agregación plaquetaria en respuesta a cada agonista (P ≤ 0,05). El mayor efecto antiplaquetario se observó con el ácido araquidónico y el menor con la mezcla de colágeno y ácido araquidónico. Se evidenció efecto de interacción entre donante y agonista (o mezclas). El estudio muestra el potencial de los extractos acuosos de ajo para prevenir la agregación plaquetaria inducida por diferentes agonistas. EEA La Consulta Fil: Gonzalez, Roxana Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina Fil: Gonzalez, Roxana Elizabeth. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza; Argentina Fil: Soto Vargas, Verónica Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina Fil: Sance, Maria Marta. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina Fil: Galmarini, Claudio Romulo. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina Fil: Galmarini, Claudio Romulo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina Fil: Galmarini, Claudio Romulo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2021-07-22T12:00:02Z 2021-07-22T12:00:02Z 2021-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/9863 https://revistas.uncu.edu.ar/ojs/index.php/RFCA/article/view/4644 0370-4661 1853-8665 https://doi.org/10.48162/rev.39.005 eng info:eu-repograntAgreement/INTA/2019-PD-E7-I152-001/2019-PD-E7-I152-001/AR./Alimentos nutracéuticos, funcionales o para regímenes especiales. info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo Revista de la Facultad de Ciencias Agrarias UNCuyo 53 (1) : 46–54. (enero-junio 2021) |
| spellingShingle | Ajo Allium Sativum Variedades Trombocitos Coagulación Sangre Garlic Varieties Platelets Coagulation Blood Gonzalez, Roxana Elizabeth Soto Vargas, Verónica Carolina Sance, María Mirta Galmarini, Claudio Romulo Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title | Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title_full | Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title_fullStr | Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title_full_unstemmed | Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title_short | Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists |
| title_sort | garlic allium sativum l inhibitory effect on platelet activity induced by different agonists |
| topic | Ajo Allium Sativum Variedades Trombocitos Coagulación Sangre Garlic Varieties Platelets Coagulation Blood |
| url | http://hdl.handle.net/20.500.12123/9863 https://revistas.uncu.edu.ar/ojs/index.php/RFCA/article/view/4644 https://doi.org/10.48162/rev.39.005 |
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