Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 da...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Sage Publishers
2021
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/9847 https://journals.sagepub.com/doi/abs/10.1177/0300985821999322 https://doi.org/10.1177/0300985821999322 |
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| author | Micheloud, Juan Francisco Lujan, Lluís Colque Caro, Luis Adrián Núñez-Montoya, Susana C. Barbeito, Claudio Gustavo Portiansky, Enrique L. Gimeno, Eduardo Juan |
| author_browse | Barbeito, Claudio Gustavo Colque Caro, Luis Adrián Gimeno, Eduardo Juan Lujan, Lluís Micheloud, Juan Francisco Núñez-Montoya, Susana C. Portiansky, Enrique L. |
| author_facet | Micheloud, Juan Francisco Lujan, Lluís Colque Caro, Luis Adrián Núñez-Montoya, Susana C. Barbeito, Claudio Gustavo Portiansky, Enrique L. Gimeno, Eduardo Juan |
| author_sort | Micheloud, Juan Francisco |
| collection | INTA Digital |
| description | Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization. |
| format | Artículo |
| id | INTA9847 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Sage Publishers |
| publisherStr | Sage Publishers |
| record_format | dspace |
| spelling | INTA98472024-03-01T10:36:57Z Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions Micheloud, Juan Francisco Lujan, Lluís Colque Caro, Luis Adrián Núñez-Montoya, Susana C. Barbeito, Claudio Gustavo Portiansky, Enrique L. Gimeno, Eduardo Juan Photosensitivity Animal Diseases Goats Poisonous Plants Enfermedades de los Animales Caprinos Plantas Tóxicas Fotosensibilidad Heterophyllaea pustulata Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization. Estación Experimental Agropecuaria Salta Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina. Fil: Luján, Lluís. Universidad de Zaragoza; España Fil: Colque-Caro, Luis A. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina. Fil: Múñez-Montoya, Susana C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina. Fil: Barbeito, Claudio G. Universidad Nacional de La Plata; Argentina. Fil: Portiansky, Enrique L. Universidad Nacional de La Plata; Argentina. Fil: Gimeno, Eduardo J. Universidad Nacional de La Plata;Argentina. 2021-07-20T12:13:59Z 2021-07-20T12:13:59Z 2021-4 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/9847 https://journals.sagepub.com/doi/abs/10.1177/0300985821999322 0300-9858 1544-2217 https://doi.org/10.1177/0300985821999322 eng info:eu-repo/semantics/restrictedAccess application/pdf Sage Publishers Veterinary Pathology 58 (3) : 568-573 (2021) |
| spellingShingle | Photosensitivity Animal Diseases Goats Poisonous Plants Enfermedades de los Animales Caprinos Plantas Tóxicas Fotosensibilidad Heterophyllaea pustulata Micheloud, Juan Francisco Lujan, Lluís Colque Caro, Luis Adrián Núñez-Montoya, Susana C. Barbeito, Claudio Gustavo Portiansky, Enrique L. Gimeno, Eduardo Juan Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title | Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title_full | Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title_fullStr | Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title_full_unstemmed | Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title_short | Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions |
| title_sort | photosensitization induced by heterophyllaea pustulata in goats sequential development of skin lesions |
| topic | Photosensitivity Animal Diseases Goats Poisonous Plants Enfermedades de los Animales Caprinos Plantas Tóxicas Fotosensibilidad Heterophyllaea pustulata |
| url | http://hdl.handle.net/20.500.12123/9847 https://journals.sagepub.com/doi/abs/10.1177/0300985821999322 https://doi.org/10.1177/0300985821999322 |
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