Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns
This experimental work reproduces the fipronil extra-label administration performed by producers in laying hens. The scientific goal was to characterize the residual concentrations in eggs from treated hens and suggest the withdrawal periods that should be respected to avoid risk for consumers. Thir...
| Main Authors: | , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Wiley
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/9349 https://onlinelibrary.wiley.com/doi/10.1111/jvp.12965 https://doi.org/10.1111/jvp.12965 |
| _version_ | 1855484378701889536 |
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| author | Canton, Lucila Canton, Candela Ceballos, Laura Dominguez, Paula Rodriguez, Jose Lanusse, Carlos Edmundo Alvarez, Luis Moreno, Laura |
| author_browse | Alvarez, Luis Canton, Candela Canton, Lucila Ceballos, Laura Dominguez, Paula Lanusse, Carlos Edmundo Moreno, Laura Rodriguez, Jose |
| author_facet | Canton, Lucila Canton, Candela Ceballos, Laura Dominguez, Paula Rodriguez, Jose Lanusse, Carlos Edmundo Alvarez, Luis Moreno, Laura |
| author_sort | Canton, Lucila |
| collection | INTA Digital |
| description | This experimental work reproduces the fipronil extra-label administration performed by producers in laying hens. The scientific goal was to characterize the residual concentrations in eggs from treated hens and suggest the withdrawal periods that should be respected to avoid risk for consumers. Thirty-four laying hens were allocated into two groups: Group A was treated with fipronil in feed, two single doses of 1 mg kg-1 day-1 ; Group B was administered a single dose of 1 mg kg-1 by the topical route. Fipronil egg residues were quantified by HPLC-MS/MS. Fipronil and its sulphone metabolite (fipronil-SO2 ) were measured in egg after both treatments. The highest egg residual profile was always for fipronil-SO2 . Mean maximum egg concentrations (Cmax ) of 228.5 ± 79.8 ng/g (fipronil) and 1,849 ± 867 ng/g (fipronil-SO2 ) were found after fipronil administration in feed. The lowest residual levels were quantified after the topical treatment with Cmax of 27.1 ± 4.9 and 163 ± 26 ng/g for fipronil and fipronil-SO2 . Mean fipronil marker residues and established MRLs allowed calculating the withdrawal periods, the shortest being 74 days after topical administration. Such a long withdrawal period is difficult to meet in egg production systems. Thus, the extra-label use of fipronil in laying hens should not be recommended under any circumstances. |
| format | Artículo |
| id | INTA9349 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA93492021-05-13T16:30:00Z Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns Canton, Lucila Canton, Candela Ceballos, Laura Dominguez, Paula Rodriguez, Jose Lanusse, Carlos Edmundo Alvarez, Luis Moreno, Laura Gallinas Ponedoras Huevos Residuos de Plaguicidas Layer Chickens Eggs Fipronil Pesticide Residues This experimental work reproduces the fipronil extra-label administration performed by producers in laying hens. The scientific goal was to characterize the residual concentrations in eggs from treated hens and suggest the withdrawal periods that should be respected to avoid risk for consumers. Thirty-four laying hens were allocated into two groups: Group A was treated with fipronil in feed, two single doses of 1 mg kg-1 day-1 ; Group B was administered a single dose of 1 mg kg-1 by the topical route. Fipronil egg residues were quantified by HPLC-MS/MS. Fipronil and its sulphone metabolite (fipronil-SO2 ) were measured in egg after both treatments. The highest egg residual profile was always for fipronil-SO2 . Mean maximum egg concentrations (Cmax ) of 228.5 ± 79.8 ng/g (fipronil) and 1,849 ± 867 ng/g (fipronil-SO2 ) were found after fipronil administration in feed. The lowest residual levels were quantified after the topical treatment with Cmax of 27.1 ± 4.9 and 163 ± 26 ng/g for fipronil and fipronil-SO2 . Mean fipronil marker residues and established MRLs allowed calculating the withdrawal periods, the shortest being 74 days after topical administration. Such a long withdrawal period is difficult to meet in egg production systems. Thus, the extra-label use of fipronil in laying hens should not be recommended under any circumstances. EEA Balcarce Fil: Canton, Lucila. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Canton, Candela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Ceballos, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Domínguez, Paula. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Rodríguez, José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Alvarez, Luís. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Moreno, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. 2021-05-13T16:09:47Z 2021-05-13T16:09:47Z 2021-03-24 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/9349 https://onlinelibrary.wiley.com/doi/10.1111/jvp.12965 1365-2885 https://doi.org/10.1111/jvp.12965 eng info:eu-repo/semantics/restrictedAccess application/pdf Wiley Journal Veterinary Pharmacology and Therapeutics : 1–12 (First published: 24 March 2021) |
| spellingShingle | Gallinas Ponedoras Huevos Residuos de Plaguicidas Layer Chickens Eggs Fipronil Pesticide Residues Canton, Lucila Canton, Candela Ceballos, Laura Dominguez, Paula Rodriguez, Jose Lanusse, Carlos Edmundo Alvarez, Luis Moreno, Laura Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title | Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title_full | Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title_fullStr | Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title_full_unstemmed | Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title_short | Oral and topical extra-label administration of fipronil to laying hens: Assessment of the egg residue patterns |
| title_sort | oral and topical extra label administration of fipronil to laying hens assessment of the egg residue patterns |
| topic | Gallinas Ponedoras Huevos Residuos de Plaguicidas Layer Chickens Eggs Fipronil Pesticide Residues |
| url | http://hdl.handle.net/20.500.12123/9349 https://onlinelibrary.wiley.com/doi/10.1111/jvp.12965 https://doi.org/10.1111/jvp.12965 |
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