Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Plos One
2021
|
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/9101 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242317 https://doi.org/10.1371/journal.pone.0242317 |
| _version_ | 1855036154040025088 |
|---|---|
| author | Brusa, Victoria Costa, Magdalena Padola, Nora Lía Etcheverría, Analía Inés Sampedro, Fernando Fernandez, Pablo S. Leotta, Gerardo Anibal Signorini Porchiett, Marcelo Lisandro |
| author_browse | Brusa, Victoria Costa, Magdalena Etcheverría, Analía Inés Fernandez, Pablo S. Leotta, Gerardo Anibal Padola, Nora Lía Sampedro, Fernando Signorini Porchiett, Marcelo Lisandro |
| author_facet | Brusa, Victoria Costa, Magdalena Padola, Nora Lía Etcheverría, Analía Inés Sampedro, Fernando Fernandez, Pablo S. Leotta, Gerardo Anibal Signorini Porchiett, Marcelo Lisandro |
| author_sort | Brusa, Victoria |
| collection | INTA Digital |
| description | We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina. |
| format | info:ar-repo/semantics/artículo |
| id | INTA9101 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Plos One |
| publisherStr | Plos One |
| record_format | dspace |
| spelling | INTA91012024-08-05T13:23:24Z Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina Brusa, Victoria Costa, Magdalena Padola, Nora Lía Etcheverría, Analía Inés Sampedro, Fernando Fernandez, Pablo S. Leotta, Gerardo Anibal Signorini Porchiett, Marcelo Lisandro Anemia Hemolítica Enfermedades Humanas Evaluación de Riesgos Carne de Res Escherichia coli Haemolytic Anaemia Human Diseases Risk Assessment Beef Argentina Síndrome Urémico Hemolítico Haemolytic Uremic Syndrome We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina. EEA Rafaela Fil: Brusa, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina Fil: Brusa, Victoria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Fil: Costa, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina Fil: Costa, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina Fil: Padola, Nora Lía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Padola, Nora Lía. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Etcheverría, Analía Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Etcheverría, Analía Inés. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Sampedro, Fernando. University of Minnesota. School of Public Health. Environmental Health Sciences Division; Estados Unidos Fil: Fernandez, Pablo S. Universidad Politécnica de Cartagena. Escuela Técnica Superior de Ingeniería Agronómica; España Fil: Leotta, Gerardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina Fil: Leotta, Gerardo Aniba. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina Fil: Signorini, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2021-04-15T16:26:58Z 2021-04-15T16:26:58Z 2020-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/9101 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242317 1932-6203 https://doi.org/10.1371/journal.pone.0242317 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Plos One PLoS ONE 15 (11) : e0242317. (2020) |
| spellingShingle | Anemia Hemolítica Enfermedades Humanas Evaluación de Riesgos Carne de Res Escherichia coli Haemolytic Anaemia Human Diseases Risk Assessment Beef Argentina Síndrome Urémico Hemolítico Haemolytic Uremic Syndrome Brusa, Victoria Costa, Magdalena Padola, Nora Lía Etcheverría, Analía Inés Sampedro, Fernando Fernandez, Pablo S. Leotta, Gerardo Anibal Signorini Porchiett, Marcelo Lisandro Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title | Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title_full | Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title_fullStr | Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title_full_unstemmed | Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title_short | Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina |
| title_sort | quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in argentina |
| topic | Anemia Hemolítica Enfermedades Humanas Evaluación de Riesgos Carne de Res Escherichia coli Haemolytic Anaemia Human Diseases Risk Assessment Beef Argentina Síndrome Urémico Hemolítico Haemolytic Uremic Syndrome |
| url | http://hdl.handle.net/20.500.12123/9101 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242317 https://doi.org/10.1371/journal.pone.0242317 |
| work_keys_str_mv | AT brusavictoria quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT costamagdalena quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT padolanoralia quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT etcheverriaanaliaines quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT sampedrofernando quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT fernandezpablos quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT leottagerardoanibal quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina AT signoriniporchiettmarcelolisandro quantitativeriskassessmentofhaemolyticuremicsyndromeassociatedwithbeefconsumptioninargentina |