Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. F...
| Main Authors: | , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2021
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| Online Access: | http://hdl.handle.net/20.500.12123/8820 https://www.sciencedirect.com/science/article/abs/pii/S0304401719301359 https://doi.org/10.1016/j.vetpar.2019.06.003 |
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| author | Muchiut, Sebastian Fernandez, Alicia Silvina Lloberas, María Mercedes Steffan, Pedro Eduard Luque, Sonia Cardozo, Patricia Alejandra Bernat, Gisele Anahí Riva, Eliana Fiel, César Alberto |
| author_browse | Bernat, Gisele Anahí Cardozo, Patricia Alejandra Fernandez, Alicia Silvina Fiel, César Alberto Lloberas, María Mercedes Luque, Sonia Muchiut, Sebastian Riva, Eliana Steffan, Pedro Eduard |
| author_facet | Muchiut, Sebastian Fernandez, Alicia Silvina Lloberas, María Mercedes Steffan, Pedro Eduard Luque, Sonia Cardozo, Patricia Alejandra Bernat, Gisele Anahí Riva, Eliana Fiel, César Alberto |
| author_sort | Muchiut, Sebastian |
| collection | INTA Digital |
| description | The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera. |
| format | Artículo |
| id | INTA8820 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA88202025-05-13T11:10:00Z Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement Muchiut, Sebastian Fernandez, Alicia Silvina Lloberas, María Mercedes Steffan, Pedro Eduard Luque, Sonia Cardozo, Patricia Alejandra Bernat, Gisele Anahí Riva, Eliana Fiel, César Alberto Oveja Parásitos Haemonchus Contortus Resistencia a los Antihelmínticos Medicamentos Ewes Parasites Resistence to Anthelmintics Drugs Benzimidazoles Fenbendazole The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera. EEA Balcarce Fil: Muchiut, Sebastian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina Fil: Fernandez, Alicia Silvina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Steffan, Pedro Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina Fil: Luque, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cardozo, Patricia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Bernat, Gisele Anahí. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina Fil: Riva, Elina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina Fil: Fiel, César Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina 2021-03-05T11:30:58Z 2021-03-05T11:30:58Z 2020-06-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8820 https://www.sciencedirect.com/science/article/abs/pii/S0304401719301359 0304-4017 https://doi.org/10.1016/j.vetpar.2019.06.003 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Veterinary Parasitology 271 : 31-37 (2019) |
| spellingShingle | Oveja Parásitos Haemonchus Contortus Resistencia a los Antihelmínticos Medicamentos Ewes Parasites Resistence to Anthelmintics Drugs Benzimidazoles Fenbendazole Muchiut, Sebastian Fernandez, Alicia Silvina Lloberas, María Mercedes Steffan, Pedro Eduard Luque, Sonia Cardozo, Patricia Alejandra Bernat, Gisele Anahí Riva, Eliana Fiel, César Alberto Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title | Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title_full | Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title_fullStr | Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title_full_unstemmed | Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title_short | Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement |
| title_sort | recovery of fenbendazole efficacy on resistant haemonchus contortus by management of parasite refugia and population replacement |
| topic | Oveja Parásitos Haemonchus Contortus Resistencia a los Antihelmínticos Medicamentos Ewes Parasites Resistence to Anthelmintics Drugs Benzimidazoles Fenbendazole |
| url | http://hdl.handle.net/20.500.12123/8820 https://www.sciencedirect.com/science/article/abs/pii/S0304401719301359 https://doi.org/10.1016/j.vetpar.2019.06.003 |
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