Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease,...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Frontiers Media
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/8689 https://www.frontiersin.org/articles/10.3389/fvets.2020.00594/full https://doi.org/10.3389/fvets.2020.00594 |
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| author | Quattrocchi, Valeria Bidart, Juan Esteban Mignaqui, Ana Clara Ruiz, Vanesa Ferella, Alejandra Langellotti, Cecilia Ana Gammella, Mariela Ferraris, Sergio Carrillo, Jorge Ernesto Wigdorovitz, Andres Durocher, Yves Cardillo, Sabrina Beatriz Charleston, Bryan Zamorano, Patricia Ines |
| author_browse | Bidart, Juan Esteban Cardillo, Sabrina Beatriz Carrillo, Jorge Ernesto Charleston, Bryan Durocher, Yves Ferella, Alejandra Ferraris, Sergio Gammella, Mariela Langellotti, Cecilia Ana Mignaqui, Ana Clara Quattrocchi, Valeria Ruiz, Vanesa Wigdorovitz, Andres Zamorano, Patricia Ines |
| author_facet | Quattrocchi, Valeria Bidart, Juan Esteban Mignaqui, Ana Clara Ruiz, Vanesa Ferella, Alejandra Langellotti, Cecilia Ana Gammella, Mariela Ferraris, Sergio Carrillo, Jorge Ernesto Wigdorovitz, Andres Durocher, Yves Cardillo, Sabrina Beatriz Charleston, Bryan Zamorano, Patricia Ines |
| author_sort | Quattrocchi, Valeria |
| collection | INTA Digital |
| description | Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of recombinant empty capsids (also referred as Virus Like Particles, VLPs) has been reported to be a promising candidate as a subunit vaccine because it avoids the use of virus in the vaccine production and conserves the conformational epitopes of the virus. Mignaqui and collaborators have produced recombinant FMDV empty capsids from serotype A/ARG/2001 using a scalable technology in mammalian cells that elicited a protective immunity against viral challenge in a mouse model. However, further evaluation of the immune response elicited by these VLPs in cattle is required. In the present work we compare the effect that VLPs or inactivated FMDV has on bovine dendritic cells and the humoral response elicited in cattle after a single vaccination. |
| format | info:ar-repo/semantics/artículo |
| id | INTA8689 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | INTA86892021-02-19T11:05:56Z Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles Quattrocchi, Valeria Bidart, Juan Esteban Mignaqui, Ana Clara Ruiz, Vanesa Ferella, Alejandra Langellotti, Cecilia Ana Gammella, Mariela Ferraris, Sergio Carrillo, Jorge Ernesto Wigdorovitz, Andres Durocher, Yves Cardillo, Sabrina Beatriz Charleston, Bryan Zamorano, Patricia Ines Aphthovirus Foot and Mouth Disease Bovinae Antibodies Viruses Virus Fiebre Aftosa Fiebre Aftosa Bovina Anticuerpos Virus Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of recombinant empty capsids (also referred as Virus Like Particles, VLPs) has been reported to be a promising candidate as a subunit vaccine because it avoids the use of virus in the vaccine production and conserves the conformational epitopes of the virus. Mignaqui and collaborators have produced recombinant FMDV empty capsids from serotype A/ARG/2001 using a scalable technology in mammalian cells that elicited a protective immunity against viral challenge in a mouse model. However, further evaluation of the immune response elicited by these VLPs in cattle is required. In the present work we compare the effect that VLPs or inactivated FMDV has on bovine dendritic cells and the humoral response elicited in cattle after a single vaccination. Instituto de Virología Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bidart, Juan Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ferella, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Langellotti, Cecilia Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gammella, Mariela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Ferraris, Sergio. Universidad Maimónides. Centro de Investigación y Desarrollo en Medicina Experimental; Argentina Fil: Carrillo, Jorge Ernesto. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigación de Agroindustria; Argentina. Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Durocher, Yves. Human Health Therapeutics Research Center, National Research Council Canada; Canadá Fil: Cardillo, Sabrina Beatriz. Biogénesis-Bagó; Argentina Fil: Charleston, Bryan. Pirbright Institute; Reino Unido Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2021-02-19T11:00:30Z 2021-02-19T11:00:30Z 2020-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8689 https://www.frontiersin.org/articles/10.3389/fvets.2020.00594/full 2297-1769 https://doi.org/10.3389/fvets.2020.00594 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Frontiers Media Frontiers in Veterinary Science 7 : 594 (Septiembre 2020) |
| spellingShingle | Aphthovirus Foot and Mouth Disease Bovinae Antibodies Viruses Virus Fiebre Aftosa Fiebre Aftosa Bovina Anticuerpos Virus Quattrocchi, Valeria Bidart, Juan Esteban Mignaqui, Ana Clara Ruiz, Vanesa Ferella, Alejandra Langellotti, Cecilia Ana Gammella, Mariela Ferraris, Sergio Carrillo, Jorge Ernesto Wigdorovitz, Andres Durocher, Yves Cardillo, Sabrina Beatriz Charleston, Bryan Zamorano, Patricia Ines Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title | Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title_full | Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title_fullStr | Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title_full_unstemmed | Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title_short | Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles |
| title_sort | bovine dendritic cell activation t cell proliferation and antibody responses to foot and mouth disease is similar with inactivated virus and virus like particles |
| topic | Aphthovirus Foot and Mouth Disease Bovinae Antibodies Viruses Virus Fiebre Aftosa Fiebre Aftosa Bovina Anticuerpos Virus |
| url | http://hdl.handle.net/20.500.12123/8689 https://www.frontiersin.org/articles/10.3389/fvets.2020.00594/full https://doi.org/10.3389/fvets.2020.00594 |
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