Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species
Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. “Valerianas” are plants that naturally grow in our region. Although some of them are used in folk medicine, they lack scientific information. We performed...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Elsevier
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/8478 https://www.sciencedirect.com/science/article/pii/S2405844020325342 https://doi.org/10.1016/j.heliyon.2020.e05691 |
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| author | Marcucci, Carolina Anselmi Relats, Juan Manuel Bach, Hernán Gerónimo Kamecki, Fabiola Varela, Beatriz Graciela Wagner, Marcelo L. Pastore, Valentina Colettis, Natalia Ricco, Rafael A. Marder, Mariel |
| author_browse | Anselmi Relats, Juan Manuel Bach, Hernán Gerónimo Colettis, Natalia Kamecki, Fabiola Marcucci, Carolina Marder, Mariel Pastore, Valentina Ricco, Rafael A. Varela, Beatriz Graciela Wagner, Marcelo L. |
| author_facet | Marcucci, Carolina Anselmi Relats, Juan Manuel Bach, Hernán Gerónimo Kamecki, Fabiola Varela, Beatriz Graciela Wagner, Marcelo L. Pastore, Valentina Colettis, Natalia Ricco, Rafael A. Marder, Mariel |
| author_sort | Marcucci, Carolina |
| collection | INTA Digital |
| description | Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. “Valerianas” are plants that naturally grow in our region. Although some of them are used in folk medicine, they lack scientific information. We performed a comparative study of the phytochemical composition and the potential in vivo effects of ethanolic extracts of argentine valerian species: Valeriana carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC., from “Patagonia Argentina”; V. ferax (Griseb.) Höck and V. effusa Griseb., from the central part of our country, and V. officinalis (as the reference plant). All these plants were rich in phenolic compounds, evidenced the presence of ligands for the benzodiazepine binding site of the GABAA receptor and were able to induce sedation as assessed by loss-of-righting reflex assays (500 mg/kg, i.p.). Mice treated with V. macrorhiza, V. carnosa and V. ferax extracts showed reduced exploratory behaviors while V. clarionifolia produced anxiolytic-like activities (500 mg/kg, i.p.) in the Hole board test. Oral administrations (300 mg/kg and 600 mg/kg, p.o.) evidenced sedative effects for V. ferax and anxiolytic-like properties for V. macrorhiza, V. carnosa and V. clarionifolia extracts. Our native valerian species are active on the CNS, validating its folkloric use as anxiolytic/sedative and sleep enhancers. |
| format | info:ar-repo/semantics/artículo |
| id | INTA8478 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA84782023-01-02T12:00:33Z Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species Marcucci, Carolina Anselmi Relats, Juan Manuel Bach, Hernán Gerónimo Kamecki, Fabiola Varela, Beatriz Graciela Wagner, Marcelo L. Pastore, Valentina Colettis, Natalia Ricco, Rafael A. Marder, Mariel Valeriana Taxonomía Plantas Medicinales Medicina Alternativa Farmacología Taxonomy Medicinal Plants Alternative Medicine Pharmacology Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. “Valerianas” are plants that naturally grow in our region. Although some of them are used in folk medicine, they lack scientific information. We performed a comparative study of the phytochemical composition and the potential in vivo effects of ethanolic extracts of argentine valerian species: Valeriana carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC., from “Patagonia Argentina”; V. ferax (Griseb.) Höck and V. effusa Griseb., from the central part of our country, and V. officinalis (as the reference plant). All these plants were rich in phenolic compounds, evidenced the presence of ligands for the benzodiazepine binding site of the GABAA receptor and were able to induce sedation as assessed by loss-of-righting reflex assays (500 mg/kg, i.p.). Mice treated with V. macrorhiza, V. carnosa and V. ferax extracts showed reduced exploratory behaviors while V. clarionifolia produced anxiolytic-like activities (500 mg/kg, i.p.) in the Hole board test. Oral administrations (300 mg/kg and 600 mg/kg, p.o.) evidenced sedative effects for V. ferax and anxiolytic-like properties for V. macrorhiza, V. carnosa and V. clarionifolia extracts. Our native valerian species are active on the CNS, validating its folkloric use as anxiolytic/sedative and sleep enhancers. Instituto de Recursos Biológicos Fil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Anselmi Relats, Juan Manuel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Varela, Beatriz G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Pastore, Valentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Ricco, Rafael A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina 2020-12-22T17:51:12Z 2020-12-22T17:51:12Z 2020-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8478 https://www.sciencedirect.com/science/article/pii/S2405844020325342 2405-8440 https://doi.org/10.1016/j.heliyon.2020.e05691 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Heliyon 6 (12) : e05691 (December 2020) |
| spellingShingle | Valeriana Taxonomía Plantas Medicinales Medicina Alternativa Farmacología Taxonomy Medicinal Plants Alternative Medicine Pharmacology Marcucci, Carolina Anselmi Relats, Juan Manuel Bach, Hernán Gerónimo Kamecki, Fabiola Varela, Beatriz Graciela Wagner, Marcelo L. Pastore, Valentina Colettis, Natalia Ricco, Rafael A. Marder, Mariel Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title | Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title_full | Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title_fullStr | Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title_full_unstemmed | Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title_short | Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| title_sort | neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species |
| topic | Valeriana Taxonomía Plantas Medicinales Medicina Alternativa Farmacología Taxonomy Medicinal Plants Alternative Medicine Pharmacology |
| url | http://hdl.handle.net/20.500.12123/8478 https://www.sciencedirect.com/science/article/pii/S2405844020325342 https://doi.org/10.1016/j.heliyon.2020.e05691 |
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