Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. C...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Springer Nature
2020
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| Online Access: | http://hdl.handle.net/20.500.12123/8175 https://www.nature.com/articles/nature13591 https://doi.org/10.1038/nature13591 |
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| author | Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerrtu Wilbur, Alicia K. Guichon, Ricardo A. Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumarraga, Martin Jose Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes |
| author_browse | Bastida, Ricardo Behr, Marcel A. Bos, Kirsten I. Bryant, Josephine M. Buikstra, Jane E. Campbell, Tessa J. Comas, Iñaki Cook, Della Collins Coscolla, Mireia Forrest, Stephen A. Gagneux, Sebastien Guichon, Ricardo A. Harkins, Kelly M. Harris, Simon R. Herbig, Alexander Huson, Daniel Krause, Johannes Majander, Kerrtu Niemann, Stefan Nieselt, Kay Parkhill, Julian Schuenemann, Verena J. Steadman, Dawnie L. Wolfe Stone, Anne C. Weber, Nico Wilbur, Alicia K. Young, Douglas Zumarraga, Martin Jose |
| author_facet | Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerrtu Wilbur, Alicia K. Guichon, Ricardo A. Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumarraga, Martin Jose Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes |
| author_sort | Bos, Kirsten I. |
| collection | INTA Digital |
| description | Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. |
| format | Artículo |
| id | INTA8175 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | dspace |
| spelling | INTA81752020-11-02T17:59:35Z Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerrtu Wilbur, Alicia K. Guichon, Ricardo A. Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumarraga, Martin Jose Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes Tuberculosis Infección Mycobacterium tuberculosis Genomas Enfermedades Humanas Mycobacterium tuberculosis Infections Genomes Human Diseases Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. Instituto de Biotecnología Fil: Bos, Kirsten I. University of Tübingen. Department of Archaeological Sciences; Alemania Fil: Harkins, Kelly M. Arizona State University. School of Human Evolution and Social Change; Estados Unidos Fil: Herbig, Alexander. University of Tübingen. Department of Archaeological Sciences; Alemania Fil: Coscolla, Mireia. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza Fil: Weber, Nico. University of Tübingen. Center for Bioinformatics; Alemania Fil: Comas, Iñaki. FISABIO-Public Health. Genomics and Health Unit; España. Centros de Investigación Biomédica en Red (CIBER) in Epidemiology and Public Health. Instituto de Salud Carlos III; España Fil: Forrest, Stephen A. University of Tübingen. Department of Archaeological Sciences; Alemania Fil: Bryant, Josephine M. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido Fil: Harris, Simon R. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido Fil: Schuenemann, Verena J. University of Tübingen. Department of Archaeological Sciences; Alemania Fil: Campbell, Tessa J. University of Cape Town. Department of Archaeology; Sudáfrica Fil: Majander, Kerrtu. University of Tübingen. Department of Archaeological Sciences; Alemania Fil: Wilbur, Alicia K. Arizona State University. School of Human Evolution and Social Change; Estados Unidos Fil: Guichon, Ricardo A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Steadman, Dawnie L. Wolfe. University of Tennessee. Department of Anthropology; Estados Unidos Fil: Cook, Della Collins. Indiana University. Department of Anthropology; Estados Unidos Fil: Niemann, Stefan. Forschungszentrum Borste. Molecular Mycobacteriology; Alemania. Forschungszentrum Borstel. German Center for Infection Research; Alemania Fil: Behr, Marcel A. McGill University. McGill International TB Centre; Canadá Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Bastida, Ricardo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Huson, Daniel. University of Tübingen. Center for Bioinformatics; Alemania Fil: Nieselt, Kay. University of Tübingen. Center for Bioinformatics; Alemania Fil: Young, Douglas. Imperial College. Department of Medicine; Reino Unido. MRC National Institute for Medical Research. Division of Mycobacterial Research; Reino Unido Fil: Parkhill, Julian. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido Fil: Buikstra, Jane E. Arizona State University. School of Human Evolution and Social Change; Estados Unidos Fil: Gagneux, Sebastien. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza Fil: Stone, Anne C. Arizona State University. School of Human Evolution and Social Change; Estados Unidos Fil: Krause, Johannes. University of Tübingen. Senckenberg Centre for Human Evolution and Palaeoenvironment; Alemania. Max Planck Institute for Science and History; Alemania 2020-11-02T17:48:51Z 2020-11-02T17:48:51Z 2014-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8175 https://www.nature.com/articles/nature13591 1476-4687 https://doi.org/10.1038/nature13591 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer Nature Nature 514 : 494-497 (Agosto 2014) |
| spellingShingle | Tuberculosis Infección Mycobacterium tuberculosis Genomas Enfermedades Humanas Mycobacterium tuberculosis Infections Genomes Human Diseases Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerrtu Wilbur, Alicia K. Guichon, Ricardo A. Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumarraga, Martin Jose Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title_full | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title_fullStr | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title_full_unstemmed | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title_short | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| title_sort | pre columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| topic | Tuberculosis Infección Mycobacterium tuberculosis Genomas Enfermedades Humanas Mycobacterium tuberculosis Infections Genomes Human Diseases |
| url | http://hdl.handle.net/20.500.12123/8175 https://www.nature.com/articles/nature13591 https://doi.org/10.1038/nature13591 |
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