Mycobacterium bovis Dmce2 double deletion mutant protects cattle against challenge with virulent M. bovis

A Mycobacterium bovis strain deleted in mce2A and mce2B genes (M. bovis Δmce2) was tested as an experimental vaccine in cattle challenged with a virulent M. bovis strain. Three-and-a-half-month old calves (n = 5 to 6 per group) were vaccinated and challenged with a virulent strain of M. bovis by the...

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Main Authors:	Blanco, Federico Carlos, Bianco, María Veronica, Garbaccio, Sergio Gabriel, Meikle, Virginia, Gravisaco, María José, Montenegro, Valeria Noely, Alfonseca, Edgar, Singh, Mahavir G., Barandiaran, Soledad, Canal, Ana María, Vagnoni, Lucas Emilio, Buddle, Bryce Malcom, Bigi, Fabiana, Cataldi, Angel Adrian
Format:	Artículo
Language:	Inglés
Published:	Elsevier 2020
Subjects:	Tuberculosis Infección por Mycobacterium bovis Vacuna Viva Ganado Bovino Organismos Patógenos Virulentos Mycobacterium bovis Infections Live Vaccines Cattle Virulent Pathogens
Online Access:	http://hdl.handle.net/20.500.12123/8172 https://www.sciencedirect.com/science/article/abs/pii/S1472979213000127 https://doi.org/10.1016/j.tube.2013.02.004