Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina
In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina using molecular tools and spatial analysis techniques. Isolates (n = 196) obtai...
| Main Authors: | , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Cambridge University Press
2020
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| Online Access: | http://hdl.handle.net/20.500.12123/8142 https://www.cambridge.org/core/journals/epidemiology-and-infection/article/tuberculosis-in-swine-coinfected-with-mycobacterium-avium-subsp-hominissuis-and-mycobacterium-bovis-in-a-cluster-from-argentina/4F0DF0A15BD55EE00D7483B232CD5341 https://doi.org/10.1017/S095026881400332X |
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| author | Barandiaran, Soledad Pérez, Andrés M. Gioffre, Andrea Martinez Vivot, Marcela Cataldi, Angel Adrian Zumarraga, Martin Jose |
| author_browse | Barandiaran, Soledad Cataldi, Angel Adrian Gioffre, Andrea Martinez Vivot, Marcela Pérez, Andrés M. Zumarraga, Martin Jose |
| author_facet | Barandiaran, Soledad Pérez, Andrés M. Gioffre, Andrea Martinez Vivot, Marcela Cataldi, Angel Adrian Zumarraga, Martin Jose |
| author_sort | Barandiaran, Soledad |
| collection | INTA Digital |
| description | In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina using molecular tools and spatial analysis techniques. Isolates (n = 196) obtained from TB-like lesions (n = 200) were characterized by polymerase chain reaction. The isolates were positive to either M. bovis (IS6110) (n = 160) or M. avium (IS1245) (n = 16) while the remaining 20 (10·2%) isolates were positive to both M. bovis and M. avium. The detection of both bacteria together suggests co-infection at the animal level. In addition, MAC-positive isolates (n = 36) were classified as M. avium subsp. avium (MAA) (n = 30) and M. avium subsp. hominissuis (MAH) (n = 6), which resulted in five genotypes when they were typed using mycobacterial interspersed repetitive unit, variable number of tandem repeats (MIRU-VNTR). One significant (P = 0·017) spatial clustering of genotypes was detected, in which the proportion of MAH isolates was larger than expected under the null hypothesis of even distribution of genotypes. These results show that in Argentina the proportion of TB cases in pigs caused by M. avium is larger than that reported in earlier studies. The proportion of M. bovis–MAC co-infections was also higher than in previous reports. These results provide valuable information on the epidemiology of MAC infection in swine in Argentina. |
| format | Artículo |
| id | INTA8142 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | INTA81422020-10-28T21:33:10Z Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina Barandiaran, Soledad Pérez, Andrés M. Gioffre, Andrea Martinez Vivot, Marcela Cataldi, Angel Adrian Zumarraga, Martin Jose Tuberculosis Mycobacterium avium subsp. paratuberculosis Mycobacterium bovis Argentina Infección PCR Cerdo Infection Swine In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina using molecular tools and spatial analysis techniques. Isolates (n = 196) obtained from TB-like lesions (n = 200) were characterized by polymerase chain reaction. The isolates were positive to either M. bovis (IS6110) (n = 160) or M. avium (IS1245) (n = 16) while the remaining 20 (10·2%) isolates were positive to both M. bovis and M. avium. The detection of both bacteria together suggests co-infection at the animal level. In addition, MAC-positive isolates (n = 36) were classified as M. avium subsp. avium (MAA) (n = 30) and M. avium subsp. hominissuis (MAH) (n = 6), which resulted in five genotypes when they were typed using mycobacterial interspersed repetitive unit, variable number of tandem repeats (MIRU-VNTR). One significant (P = 0·017) spatial clustering of genotypes was detected, in which the proportion of MAH isolates was larger than expected under the null hypothesis of even distribution of genotypes. These results show that in Argentina the proportion of TB cases in pigs caused by M. avium is larger than that reported in earlier studies. The proportion of M. bovis–MAC co-infections was also higher than in previous reports. These results provide valuable information on the epidemiology of MAC infection in swine in Argentina. Instituto de Biotecnología Fil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Pérez, Andrés M. University of Minnesota. College of Veterinary Medicine; Estados Unidos Fil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Martinez Vivot, Marcela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina 2020-10-28T21:26:54Z 2020-10-28T21:26:54Z 2015-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8142 https://www.cambridge.org/core/journals/epidemiology-and-infection/article/tuberculosis-in-swine-coinfected-with-mycobacterium-avium-subsp-hominissuis-and-mycobacterium-bovis-in-a-cluster-from-argentina/4F0DF0A15BD55EE00D7483B232CD5341 1469-4409 https://doi.org/10.1017/S095026881400332X eng info:eu-repograntAgreement/INTA/AESA-202831/AR./Tuberculosis y Paratuberculosis”. Diagnóstico con métodos desarrollados, pruebas con antígenos e inmunógenos noveles y estrategias zooepidemiológicas para su control en relación a Salud Publica. info:eu-repo/semantics/restrictedAccess application/pdf Cambridge University Press Epidemiology & Infection 143 (5) : 966-974 (Abril 2015) |
| spellingShingle | Tuberculosis Mycobacterium avium subsp. paratuberculosis Mycobacterium bovis Argentina Infección PCR Cerdo Infection Swine Barandiaran, Soledad Pérez, Andrés M. Gioffre, Andrea Martinez Vivot, Marcela Cataldi, Angel Adrian Zumarraga, Martin Jose Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title | Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title_full | Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title_fullStr | Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title_full_unstemmed | Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title_short | Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina |
| title_sort | tuberculosis in swine co infected with mycobacterium avium subsp hominissuis and mycobacterium bovis in a cluster from argentina |
| topic | Tuberculosis Mycobacterium avium subsp. paratuberculosis Mycobacterium bovis Argentina Infección PCR Cerdo Infection Swine |
| url | http://hdl.handle.net/20.500.12123/8142 https://www.cambridge.org/core/journals/epidemiology-and-infection/article/tuberculosis-in-swine-coinfected-with-mycobacterium-avium-subsp-hominissuis-and-mycobacterium-bovis-in-a-cluster-from-argentina/4F0DF0A15BD55EE00D7483B232CD5341 https://doi.org/10.1017/S095026881400332X |
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